Functional hubs in mild cognitive impairment

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to invest...

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Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24334
Acceso en línea:
https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
Palabra clave:
Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
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License
Abierto (Texto Completo)
Description
Summary:We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.