Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood
Objectives: To verify the paper of environmental risks in the process of developing Acute lymphoblastic leukemia (ALL) in childhood. Materials and methods: A search was conducted on scientific literature in order to evaluate the role of environmental risk factors in acute lymphoblastic leukemia deve...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/15180
- Acceso en línea:
- https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.5386
http://repository.urosario.edu.co/handle/10336/15180
- Palabra clave:
- Leucemia
Factores ambientales
Infancia.
Leukemia
Environmental factors
Childhood
Fatores ambientais
Infância
- Rights
- License
- Copyright (c) 2017 Revista Ciencias de la Salud
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| dc.title.eng.fl_str_mv |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| dc.title.TranslatedTitle.spa.fl_str_mv |
Factores de riesgo ambientales y leucemia linfoblástica aguda en la infancia |
| dc.title.TranslatedTitle.por.fl_str_mv |
Fatores de risco ambientais e leucemia linfoblástica aguda na infância |
| title |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| spellingShingle |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood Leucemia Factores ambientales Infancia. Leukemia Environmental factors Childhood Fatores ambientais Infância |
| title_short |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| title_full |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| title_fullStr |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| title_full_unstemmed |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| title_sort |
Environmental Risk Factors and Acute Lymphoblastic Leukaemia in Childhood |
| dc.contributor.none.fl_str_mv |
College of Technology of the State of São Paulo and Department of Environmental Health- School of Public Health Department of Epidemiology, School of Public Health Department of Environmental Health, School of Public Health, University of São Paulo College of Technology of the State of São Paulo and Department of Environmental Health- School of Public Health Department of Epidemiology, School of Public Health Department of Environmental Health, School of Public Health, University of São Paulo College of Technology of the State of São Paulo and Department of Environmental Health- School of Public Health Department of Epidemiology, School of Public Health Department of Environmental Health, School of Public Health, University of São Paulo |
| dc.subject.spa.fl_str_mv |
Leucemia Factores ambientales Infancia. |
| topic |
Leucemia Factores ambientales Infancia. Leukemia Environmental factors Childhood Fatores ambientais Infância |
| dc.subject.keyword.eng.fl_str_mv |
Leukemia Environmental factors Childhood |
| dc.subject.keyword.por.fl_str_mv |
Fatores ambientais Infância |
| description |
Objectives: To verify the paper of environmental risks in the process of developing Acute lymphoblastic leukemia (ALL) in childhood. Materials and methods: A search was conducted on scientific literature in order to evaluate the role of environmental risk factors in acute lymphoblastic leukemia development. Results: The environmental role in development of all in children is unknown. The two steps theory proposed by Greaves in 1988 is the most acceptable hypothesis. One first event occurs in uterus or near the moment of birth; this mutation induces the development of pre-leukemia clones. Another event, happening in the early infancy, would develop this rst pre-leukemia clone into clinical leukemia. Based on the environmental events linked to other types of leukemia and in other studies, some risk factors have been proposed as inducing the mutations leading to all. Radiation (ionizing or not), infectious agents, and chemical products are thought to be the responsible for the disease. In the last decades, many authors tried to found an association between these risk factors and the development of childhood ALL. The results however were inconclusive and even contradictories. Ionizing radiation is the only one proved to play a role in the development of leukemia. Conclusion: As leukemia is a disease that affects children, costs of this pathology are high when talking about money expend for diagnosis and treatment and when thinking on the social and psychological burden. Considering the theory proposed by Greaves, there are at least, two moments, when the patient should avoid the exposition that leads to leukemia. Therefore, it is very important to nd the real risk factor or factors that are involved in the process. |
| publishDate |
2017 |
| dc.date.created.none.fl_str_mv |
2017-01-31 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2018-03-05T12:24:43Z |
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2018-03-05T12:24:43Z |
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article |
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Artículo |
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https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.5386 |
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2145-4507 1692-7273 |
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http://repository.urosario.edu.co/handle/10336/15180 |
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https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.5386 http://repository.urosario.edu.co/handle/10336/15180 |
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2145-4507 1692-7273 |
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eng spa |
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eng spa |
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https://revistas.urosario.edu.co/index.php/revsalud/article/view/5386 |
| dc.rights.spa.fl_str_mv |
Copyright (c) 2017 Revista Ciencias de la Salud |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto completo) |
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http://creativecommons.org/licenses/by-nc/4.0 |
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Copyright (c) 2017 Revista Ciencias de la Salud Abierto (Texto completo) http://creativecommons.org/licenses/by-nc/4.0 http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Universidad del Rosario |
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Escuela de Medicina y Ciencias de la Salud |
| dc.source.eng.fl_str_mv |
Revista Ciencias de la Salud; Vol. 15, No. 1 (2017); 129-144 |
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Revista Ciencias de la Salud; Vol. 15, Núm. 1 (2017); 129-144 10.12804/revistas.urosario.edu.co/revsalud/vol15num12017 |
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Revista Ciencias de la Salud; V. 15, n. 1 (2017); 129-144 |
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Universidad del Rosario |
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College of Technology of the State of São Paulo and Department of Environmental Health- School of Public HealthDepartment of Epidemiology, School of Public HealthDepartment of Environmental Health, School of Public Health, University of São PauloCollege of Technology of the State of São Paulo and Department of Environmental Health- School of Public HealthDepartment of Epidemiology, School of Public HealthDepartment of Environmental Health, School of Public Health, University of São PauloCollege of Technology of the State of São Paulo and Department of Environmental Health- School of Public HealthDepartment of Epidemiology, School of Public HealthDepartment of Environmental Health, School of Public Health, University of São PauloCangerana Pereira, Fernanda AlvesMirra, Antônio PedroDias de Oliveira Latorre, Maria do RosárioDe Assunção, João Vicentee2b90720-01da-4132-b710-2458f51766ce49630874-1855-4fb3-a619-c0e74333036d43ebebb5-e599-4933-b8d5-f16b5587492d6ba1c5d5-9429-4dff-9ec9-56783df63abd2018-03-05T12:24:43Z2018-03-05T12:24:43Z2017-01-312017Objectives: To verify the paper of environmental risks in the process of developing Acute lymphoblastic leukemia (ALL) in childhood. Materials and methods: A search was conducted on scientific literature in order to evaluate the role of environmental risk factors in acute lymphoblastic leukemia development. Results: The environmental role in development of all in children is unknown. The two steps theory proposed by Greaves in 1988 is the most acceptable hypothesis. One first event occurs in uterus or near the moment of birth; this mutation induces the development of pre-leukemia clones. Another event, happening in the early infancy, would develop this rst pre-leukemia clone into clinical leukemia. Based on the environmental events linked to other types of leukemia and in other studies, some risk factors have been proposed as inducing the mutations leading to all. Radiation (ionizing or not), infectious agents, and chemical products are thought to be the responsible for the disease. In the last decades, many authors tried to found an association between these risk factors and the development of childhood ALL. The results however were inconclusive and even contradictories. Ionizing radiation is the only one proved to play a role in the development of leukemia. Conclusion: As leukemia is a disease that affects children, costs of this pathology are high when talking about money expend for diagnosis and treatment and when thinking on the social and psychological burden. Considering the theory proposed by Greaves, there are at least, two moments, when the patient should avoid the exposition that leads to leukemia. Therefore, it is very important to nd the real risk factor or factors that are involved in the process.Objetivos: Verificar el papel de los riesgos ambientales en el proceso de desarrollo de la leucemia linfoblástica aguda (LLA) en la infancia. Materiales y métodos: Se realizó una búsqueda en la literatura científica con el fin de evaluar el papel de los factores de riesgo ambientales en el desarrollo de la leucemia linfoblástica aguda. Resultados: El papel del medio ambiente en el desarrollo de la lla en niños es desconocida. La teoría de dos etapas propuesta por Greaves, en 1988 es la hipótesis más aceptable. Un primer evento se produce en el útero o cerca del momento del nacimiento; esta mutación induce el desarrollo de clones pre-leucemia. Otro acontecimiento, suceso en la infancia temprana, se desarrollaría este primer clon de pre-leucemia en leucemia clínica. Con base en los eventos ambientales relacionados con otros tipos de leucemia y en otros estudios, algunos factores de riesgo se han propuesto como la inducción de las mutaciones que conducen a lla. Radiación (ionizante o no), agentes infecciosos, y productos químicos se cree que son los responsables de la enfermedad. En las últimas décadas, muchos autores intentaron encontrado una asociación entre estos factores de riesgo y el desarrollo de la LLA infantil. Sin embargo los resultados no fueron concluyentes e incluso contradictorias. La radiación ionizante es el único demostrado desempeñar un papel en el desarrollo de la leucemia. Conclusión: Como la leucemia es una enfermedad que afecta a los niños, los costos de esta patología son altos cuando se habla de dinero gastar para el diagnóstico y tratamiento y cuando se piensa en la carga social y psicológico. Teniendo en cuenta la teoría propuesta por Greaves, hay por lo menos dos momentos cuando el paciente debe evitar la exposición que conduce a la leucemia. Por lo tanto, es muy importante encontrar el factor de riesgo real, o factores, que están involucrados en el proceso. Objetivos: Para veri car o papel dos riscos ambientais no processo de desenvolvimento da leucemia linfoblástica aguda (LLA) na infância. Materiais e métodos: realizou-se uma busca na literatura científica com o fim de avaliar o papel dos fatores de risco ambientais no desenvolvimento da leucemia linfoblástica aguda. Resultados: O papel do meio ambiente no desenvolvimento da LLA em crianças é desconhecido. A teoria de duas etapas proposto por Greaves, em 1988 é a hipótese mais aceitável. Um primeiro evento se produz “no útero” ou perto do momento do nascimento; esta mutação induz o desenvolvimento de clones pré-leucemia. Outro acontecimento, sucedido na infância precoce, se desenvolveria este primeiro clone de pré-leucemia em leucemia clínica. Com base nos eventos ambientais relacionados com outros tipos de leucemia e em outros estudos, alguns fatores de risco se têm proposto como a indução das mutações que conduzem a LLA infantil. Radiação (ionizante ou não), agentes infecciosos, e produtos químicos acredita-se que são responsáveis da doença. Nas últimas décadas, muitos autores tentaram encontrar uma associação entre estes fatores de risco e o desenvolvimento da LLA infantil. No entanto, os resultados não foram concludentes e inclusive contraditórios. A radiação ionizante é o único demonstrado desempenhar um papel no desenvolvimento da leucemia. Conclusão: Como a leucemia é uma doença que afeta às crianças, os custos desta patologia são altos quando se fala de dinheiro gasto para o diagnóstico e tratamento, e quando se pensa na carga social e psicológica. Tendo em conta a teoria proposta por Greaves, há pelo menos dois momentos quando o paciente deve evitar a exposição que conduz à leucemia. Pelo tanto, é muito importante encontrar o fator de risco real, ou fatores, que estão envolvidos no processo. application/pdfhttps://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.53862145-45071692-7273http://repository.urosario.edu.co/handle/10336/15180engspaUniversidad del RosarioEscuela de Medicina y Ciencias de la Saludhttps://revistas.urosario.edu.co/index.php/revsalud/article/view/5386Copyright (c) 2017 Revista Ciencias de la SaludAbierto (Texto completo)http://creativecommons.org/licenses/by-nc/4.0http://purl.org/coar/access_right/c_abf2Revista Ciencias de la Salud; Vol. 15, No. 1 (2017); 129-144Revista Ciencias de la Salud; Vol. 15, Núm. 1 (2017); 129-14410.12804/revistas.urosario.edu.co/revsalud/vol15num12017Revista Ciencias de la Salud; V. 15, n. 1 (2017); 129-144instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURLeucemiaFactores ambientalesInfancia.LeukemiaEnvironmental factorsChildhoodFatores ambientaisInfânciaEnvironmental Risk Factors and Acute Lymphoblastic Leukaemia in ChildhoodFactores de riesgo ambientales y leucemia linfoblástica aguda en la infanciaFatores de risco ambientais e leucemia linfoblástica aguda na infânciaarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501ORIGINALEnvironmental-Risk-Factors.pdfEnvironmental-Risk-Factors.pdfapplication/pdf194611https://repository.urosario.edu.co/bitstreams/2a2120aa-6736-44d3-8a0d-abd33b9e60a5/download3196b9ea44a6d11ef471fd2a00d2e07dMD51TEXTEnvironmental-Risk-Factors.pdf.txtEnvironmental-Risk-Factors.pdf.txtExtracted texttext/plain51819https://repository.urosario.edu.co/bitstreams/80192541-a995-4537-a45c-46803b4c3b14/downloada50459cdd2b134d1da4572300bdda82fMD52THUMBNAILEnvironmental-Risk-Factors.pdf.jpgEnvironmental-Risk-Factors.pdf.jpgGenerated Thumbnailimage/jpeg3870https://repository.urosario.edu.co/bitstreams/fc6859c8-e82a-43ba-bdf2-b97802af86b2/download45722c75b5f599c05e8f0ba3bb816a43MD5310336/15180oai:repository.urosario.edu.co:10336/151802022-08-24 11:20:21.238269http://creativecommons.org/licenses/by-nc/4.0Copyright (c) 2017 Revista Ciencias de la Saludhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |