Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis

Background Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training mod...

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Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27579
Acceso en línea:
https://doi.org/10.1186/s12885-015-1069-4
https://repository.urosario.edu.co/handle/10336/27579
Palabra clave:
Breast neoplasms
Exercise
Resistance training
Rehabilitation
Medical oncology
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spelling 3244bfc7-1ee8-4cf6-911f-24f10160eed3-1b3c37ea2-bb71-4010-a7b6-4f366c598d21-194518183-12020-08-19T14:42:49Z2020-08-19T14:42:49Z2015-02-21Background Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. Methods This study aimed to determine the pooled effects of supervised exercise interventions on CRF in breast cancer survivors. We searched PubMed/MEDLINE, EMBASE, Scopus, CENTRAL and CINAHL databases between December 2013 and January 2014 without language restrictions. Risk of bias and methodological quality were evaluated using the PEDro score. Pooled effects were calculated with a random-effects model according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Results Nine high-quality studies (n?=?1156) were finally included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD?=??0.51, 95%CI ?0.81 to ?0.21), with high statistical heterogeneity (P?=?0.001; I2?=?75%). Similar effects were found for resistance training on CRF (SMD?=??0.41, 95%CI ?0.76 to ?0.05; P?=?0.02; I2?=?64%). Meta-regression analysis revealed that exercise volume parameters are closely related with the effect estimates on CRF. Egger’s test suggested moderate evidence of publication bias (P?=?0.04). Conclusions Supervised exercise reduces CRF and must be implemented in breast cancer rehabilitation settings. High-volume exercises are safe and effective in improving CRF and overall quality of life in women with breast cancer. Further research is encouraged.application/pdfhttps://doi.org/10.1186/s12885-015-1069-4EISSN: 1471-2407https://repository.urosario.edu.co/handle/10336/27579engBioMed CentralNo. 77BMC CancerVol. 15BMC Cancer, EISSN: 1471-2407, Vol.15, No.77 (2015); 13 pp. https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-015-1069-4Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2BMC Cancerinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBreast neoplasmsExerciseResistance trainingRehabilitationMedical oncologyEffects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysisEfectos del ejercicio supervisado sobre la fatiga relacionada con el cáncer en sobrevivientes de cáncer de mama: una revisión sistemática y un metanálisisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Meneses-Echávez, José FranciscoGonzález-Jiménez, EmilioRamírez-Vélez, RobinsonORIGINALs12885-015-1069-4.pdfapplication/pdf1780920https://repository.urosario.edu.co/bitstreams/0228fb09-3bf2-4f1b-a4e4-b35ea7246bce/download2f388ce427464c0cab957474c8d797afMD51TEXTs12885-015-1069-4.pdf.txts12885-015-1069-4.pdf.txtExtracted texttext/plain50296https://repository.urosario.edu.co/bitstreams/4403897b-78aa-42b6-be51-9d7cf5de32a0/downloadb00fc000830bc6878978e4ba6c0c1551MD52THUMBNAILs12885-015-1069-4.pdf.jpgs12885-015-1069-4.pdf.jpgGenerated Thumbnailimage/jpeg4449https://repository.urosario.edu.co/bitstreams/362e3cf9-dbfa-41f6-83b1-41f83c280b2e/download6e940471c6eb2207ecc58fa55a0c9ea5MD5310336/27579oai:repository.urosario.edu.co:10336/275792022-05-02 07:37:13.420518https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
dc.title.TranslatedTitle.spa.fl_str_mv Efectos del ejercicio supervisado sobre la fatiga relacionada con el cáncer en sobrevivientes de cáncer de mama: una revisión sistemática y un metanálisis
title Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
spellingShingle Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
Breast neoplasms
Exercise
Resistance training
Rehabilitation
Medical oncology
title_short Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
title_full Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
title_fullStr Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
title_full_unstemmed Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
title_sort Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
dc.subject.keyword.spa.fl_str_mv Breast neoplasms
Exercise
Resistance training
Rehabilitation
Medical oncology
topic Breast neoplasms
Exercise
Resistance training
Rehabilitation
Medical oncology
description Background Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. Methods This study aimed to determine the pooled effects of supervised exercise interventions on CRF in breast cancer survivors. We searched PubMed/MEDLINE, EMBASE, Scopus, CENTRAL and CINAHL databases between December 2013 and January 2014 without language restrictions. Risk of bias and methodological quality were evaluated using the PEDro score. Pooled effects were calculated with a random-effects model according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Results Nine high-quality studies (n?=?1156) were finally included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD?=??0.51, 95%CI ?0.81 to ?0.21), with high statistical heterogeneity (P?=?0.001; I2?=?75%). Similar effects were found for resistance training on CRF (SMD?=??0.41, 95%CI ?0.76 to ?0.05; P?=?0.02; I2?=?64%). Meta-regression analysis revealed that exercise volume parameters are closely related with the effect estimates on CRF. Egger’s test suggested moderate evidence of publication bias (P?=?0.04). Conclusions Supervised exercise reduces CRF and must be implemented in breast cancer rehabilitation settings. High-volume exercises are safe and effective in improving CRF and overall quality of life in women with breast cancer. Further research is encouraged.
publishDate 2015
dc.date.created.spa.fl_str_mv 2015-02-21
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:42:49Z
dc.date.available.none.fl_str_mv 2020-08-19T14:42:49Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1186/s12885-015-1069-4
dc.identifier.issn.none.fl_str_mv EISSN: 1471-2407
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https://repository.urosario.edu.co/handle/10336/27579
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dc.language.iso.spa.fl_str_mv eng
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dc.relation.citationIssue.none.fl_str_mv No. 77
dc.relation.citationTitle.none.fl_str_mv BMC Cancer
dc.relation.citationVolume.none.fl_str_mv Vol. 15
dc.relation.ispartof.spa.fl_str_mv BMC Cancer, EISSN: 1471-2407, Vol.15, No.77 (2015); 13 pp.
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dc.source.spa.fl_str_mv BMC Cancer
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