Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome...

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Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24298
Acceso en línea:
https://doi.org/10.1016/j.meegid.2015.05.001
https://repository.urosario.edu.co/handle/10336/24298
Palabra clave:
Allele
Article
Dna polymorphism
Dna sequence
Gene mutation
Genetic variability
Merozoite
Microbial gene
Multigene family
Natural selection
Nonhuman
Plasmodium vivax
Priority journal
Signal transduction
Biology
Genetic polymorphism
Genetic selection
Genetic variation
Genetics
Host parasite interaction
Metabolism
Phylogeny
Physiology
Plasmodium vivax
Plasmodium parasites
Plasmodium vivax
Protozoal protein
Computational biology
Genetic variation
Host-parasite interactions
Phylogeny
Plasmodium vivax
Protozoan proteins
Allele-specific response
Anti-malarial vaccine
Natural selection signal
Plasmodium vivax
dna
genetic
genetic
Polymorphism
Selection
Sequence analysis
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Description
Summary:Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V.