The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians

Sjögren's syndrome (SS) and Type 1 Diabetes (T1D) are chronic, progressive autoimmune diseases that affect exocrine glands or ?-cells in the islets of Langerhans in the pancreas, respectively. Typical features of both diseases include production of antibodies against self-antigens and T and B c...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26418
Acceso en línea:
https://doi.org/10.1016/j.clim.2013.05.010
https://repository.urosario.edu.co/handle/10336/26418
Palabra clave:
Chemokine receptor CCR5
DNA
Cell migration
Cell surface
Colombia
DNA polymorphism
Frameshift mutation
Gene deletion
Gene frequency
Genetic association
Genotype
Human
Insulin dependent diabetes mellitus
Letter
Leukocyte
Priority journal
Sjoegren syndrome
CCR5 delta 32
Rs333
Sjögren's syndrome
Type 1 Diabetes
Colombia
Diabetes Mellitus Type 1
Genetic Predisposition to Disease
Humans
Polymorphism Genetic
Receptors CCR5
Sjogren's Syndrome
CCR5 delta 32
Rs333
Sjögren's syndrome
Type 1 Diabetes
Rights
License
Restringido (Acceso a grupos específicos)
Description
Summary:Sjögren's syndrome (SS) and Type 1 Diabetes (T1D) are chronic, progressive autoimmune diseases that affect exocrine glands or ?-cells in the islets of Langerhans in the pancreas, respectively. Typical features of both diseases include production of antibodies against self-antigens and T and B cell infiltrates in organ-specific tissues [12] . Migration of pro-inflammatory memory T cells and monocytes into chronically inflamed tissues is driven by Th1-related chemokines and their receptors. This includes CCR5, a seven-transmembrane domain G protein-coupled receptor (GPCR) involved in intracellular signaling [3] . In Sjögren's syndrome, mRNA and receptor expression of CCR5 are significantly upregulated in inflammatory Th1 cells, parotid gland excretory ducts and conjunctival epithelium of SS-affected individuals indicating that it has a significant role in the progression and severity of pSS disease [45] . In Type 1 Diabetes, recruitment of activated CCR5-expressing T cells to the pancreas or kidney can promote renal disease and impairment of insulin production [6] .