CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba
Background: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3. years of infection) in Cuba. Methods: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/19047
- Acceso en línea:
- http://repository.urosario.edu.co/handle/10336/19047
- Palabra clave:
- Crf19
Cuba
Hiv-1
Progression To Aids
Variant
Grupos sociales
Alpha Interferon
Beta 2 Microglobulin
Chemokine Receptor Ccr5
Chemokine Receptor Cxcr4
Cxcl9 Chemokine
Fas Ligand
Gamma Interferon
Gamma Interferon Inducible Protein 1
Granulocyte Colony Stimulating Factor
Interleukin 1
Interleukin 12P7
Interleukin 1Beta
Interleukin 2
Interleukin 4
Interleukin 5
Interleukin 6
Interleukin 8
Lymphotoxin
Macrophage Inflammatory Protein 1Alpha
Macrophage Inflammatory Protein 1Beta
Monocyte Chemotactic Protein 1
Neopterin
Rantes
Tumor Necrosis Factor Alpha
Pol Protein
Virus Envelope Protein
Acquired Immune Deficiency Syndrome
Adult
Antiviral Resistance
Article
Cd4 Lymphocyte Count
Controlled Study
Cuba
Disease Course
Enzyme Linked Immunosorbent Assay
Female
Genetic Analysis
Genetic Variability
Heterosexuality
Human
Human Immunodeficiency Virus 1 Infection
Immunity
Major Clinical Study
Male
Mixed Infection
Priority Journal
Prospective Study
Reproductive Fitness
Retrospective Study
Thrush
Virus Load
Virus Recombination
Virus Replication
Virus Transmission
Virus Typing
Young Adult
Acquired Immunodeficiency Syndrome
Drug Effects
Evolution
Genetic Variation
Genetics
Hiv Infections
Human Immunodeficiency Virus 1
Immunology
Pathogenicity
Sexual Behavior
Virology
Acquired Immunodeficiency Syndrome
Adult
Biological Evolution
Coinfection
Cuba
Drug Resistance, Viral
Env Gene Products, Human Immunodeficiency Virus
Female
Genetic Variation
Hiv Infections
Hiv-1
Humans
Male
Pol Gene Products, Human Immunodeficiency Virus
Retrospective Studies
Sexual Behavior
Viral Load
Young Adult
Enfermedad del sida
Personas VIH positivas
- Rights
- License
- Abierto (Texto Completo)
Summary: | Background: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3. years of infection) in Cuba. Methods: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as >. 3. years infected. Clinical, demographic, virological, epidemiological and immunological data were collected. Pol and env sequences were used for subtyping, transmission cluster analysis, and prediction of resistance, co-receptor use and evolutionary fitness. Host, immunological and viral predictors of RP were explored through data mining. Findings: Subtyping revealed 26 subtype B strains, 6 C, 6 CRF18_cpx, 9 CRF19_cpx, 29 BG-recombinants and other subtypes/URFs. All patients infected with CRF19 belonged to the AIDS-RP group. Data mining identified CRF19, oral candidiasis and RANTES levels as the strongest predictors of AIDS-RP. CRF19 was more frequently predicted to use the CXCR4 co-receptor, had higher fitness scores in the protease region, and patients had higher viral load at diagnosis. Interpretation: CRF19 is a recombinant of subtype D (C-part of Gag, PR, RT and nef), subtype A (N-part of Gag, Integrase, Env) and subtype G (Vif, Vpr, Vpu and C-part of Env). Since subtypes D and A have been associated with respectively faster and slower disease progression, our findings might indicate a fit PR driving high viral load, which in combination with co-infections may boost RANTES levels and thus CXCR4 use, potentially explaining the fast progression. We propose that CRF19 is evolutionary very fit and causing rapid progression to AIDS in many newly infected patients in Cuba. © 2015. |
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