Delayed lupus nephritis

Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ?5 years after the fir...

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Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22356
Acceso en línea:
https://doi.org/10.1136/ard.2008.088740
https://repository.urosario.edu.co/handle/10336/22356
Palabra clave:
Antiphospholipid syndrome
Article
Autoimmunity
Controlled study
Disease association
Disease course
Histopathology
Human
Human tissue
Kidney biopsy
Lupus erythematosus nephritis
Major clinical study
Nephritis
Nephrotic syndrome
Priority journal
Sjoegren syndrome
Systemic lupus erythematosus
Adult
Antiphospholipid syndrome
Cross-sectional studies
Disease susceptibility
Female
Humans
Lupus nephritis
Male
Middle aged
Risk factors
Sjogren's syndrome
Time factors
antinuclear
Antibodies
Rights
License
Abierto (Texto Completo)
id EDOCUR2_67374c5ac0f3a9ce9d39435b8da6d73f
oai_identifier_str oai:repository.urosario.edu.co:10336/22356
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 14235855-a173-4fe8-9d0d-9e1e61f0ade34fa6600b-d26e-41c7-beb2-9b5fe3cf995b5b8c5949-2cbd-47af-bc21-8300462509a48aa08ddc-3b0d-4a49-a320-6a8b48a80d5051bfd9fc-9c30-4bfa-948a-05d1b05eaf92457fd501-80b8-4e4e-9ff4-a9156634e8b233572bf7-eb40-4a55-8738-3ca6e62a6004329853ec-676a-43b0-bd65-7a24f8e13569194747786002020-05-25T23:56:11Z2020-05-25T23:56:11Z2008Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ?5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sjögren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.application/pdfhttps://doi.org/10.1136/ard.2008.0887400003496714682060https://repository.urosario.edu.co/handle/10336/22356eng1046No. 71044Annals of the Rheumatic DiseasesVol. 67Annals of the Rheumatic Diseases, ISSN:00034967, 14682060, Vol.67, No.7 (2008); pp. 1044-1046https://www.scopus.com/inward/record.uri?eid=2-s2.0-46849094953&doi=10.1136%2fard.2008.088740&partnerID=40&md5=6aa324e4862cdd95a4a0e2d4f1ce28efAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAntiphospholipid syndromeArticleAutoimmunityControlled studyDisease associationDisease courseHistopathologyHumanHuman tissueKidney biopsyLupus erythematosus nephritisMajor clinical studyNephritisNephrotic syndromePriority journalSjoegren syndromeSystemic lupus erythematosusAdultAntiphospholipid syndromeCross-sectional studiesDisease susceptibilityFemaleHumansLupus nephritisMaleMiddle agedRisk factorsSjogren's syndromeTime factorsantinuclearAntibodiesDelayed lupus nephritisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Varela, D-CQuintana, GSomers, E CRojas-Villarraga, AEspinosa, GHincapie, M-EMcCune, W JCervera, RAnaya, Juan-Manuel10336/22356oai:repository.urosario.edu.co:10336/223562022-05-02 07:37:13.470804https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Delayed lupus nephritis
title Delayed lupus nephritis
spellingShingle Delayed lupus nephritis
Antiphospholipid syndrome
Article
Autoimmunity
Controlled study
Disease association
Disease course
Histopathology
Human
Human tissue
Kidney biopsy
Lupus erythematosus nephritis
Major clinical study
Nephritis
Nephrotic syndrome
Priority journal
Sjoegren syndrome
Systemic lupus erythematosus
Adult
Antiphospholipid syndrome
Cross-sectional studies
Disease susceptibility
Female
Humans
Lupus nephritis
Male
Middle aged
Risk factors
Sjogren's syndrome
Time factors
antinuclear
Antibodies
title_short Delayed lupus nephritis
title_full Delayed lupus nephritis
title_fullStr Delayed lupus nephritis
title_full_unstemmed Delayed lupus nephritis
title_sort Delayed lupus nephritis
dc.subject.keyword.spa.fl_str_mv Antiphospholipid syndrome
Article
Autoimmunity
Controlled study
Disease association
Disease course
Histopathology
Human
Human tissue
Kidney biopsy
Lupus erythematosus nephritis
Major clinical study
Nephritis
Nephrotic syndrome
Priority journal
Sjoegren syndrome
Systemic lupus erythematosus
Adult
Antiphospholipid syndrome
Cross-sectional studies
Disease susceptibility
Female
Humans
Lupus nephritis
Male
Middle aged
Risk factors
Sjogren's syndrome
Time factors
topic Antiphospholipid syndrome
Article
Autoimmunity
Controlled study
Disease association
Disease course
Histopathology
Human
Human tissue
Kidney biopsy
Lupus erythematosus nephritis
Major clinical study
Nephritis
Nephrotic syndrome
Priority journal
Sjoegren syndrome
Systemic lupus erythematosus
Adult
Antiphospholipid syndrome
Cross-sectional studies
Disease susceptibility
Female
Humans
Lupus nephritis
Male
Middle aged
Risk factors
Sjogren's syndrome
Time factors
antinuclear
Antibodies
dc.subject.keyword.eng.fl_str_mv antinuclear
Antibodies
description Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ?5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sjögren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.
publishDate 2008
dc.date.created.spa.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:56:11Z
dc.date.available.none.fl_str_mv 2020-05-25T23:56:11Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1136/ard.2008.088740
dc.identifier.issn.none.fl_str_mv 00034967
14682060
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22356
url https://doi.org/10.1136/ard.2008.088740
https://repository.urosario.edu.co/handle/10336/22356
identifier_str_mv 00034967
14682060
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1046
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 1044
dc.relation.citationTitle.none.fl_str_mv Annals of the Rheumatic Diseases
dc.relation.citationVolume.none.fl_str_mv Vol. 67
dc.relation.ispartof.spa.fl_str_mv Annals of the Rheumatic Diseases, ISSN:00034967, 14682060, Vol.67, No.7 (2008); pp. 1044-1046
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-46849094953&doi=10.1136%2fard.2008.088740&partnerID=40&md5=6aa324e4862cdd95a4a0e2d4f1ce28ef
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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