Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis

Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs...

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Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23271
Acceso en línea:
https://doi.org/10.1080/03009742.2018.1469164
https://repository.urosario.edu.co/handle/10336/23271
Palabra clave:
Cyclic citrullinated peptide antibody
Immunoglobulin g
Cyclic citrullinated peptide antibody
Arthritis
Arthropathy
Article
Cochrane library
Human
Medline
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Synovitis
Systematic review
Web of science
Complication
Immunology
Meta analysis
Sjoegren syndrome
Anti-citrullinated protein antibodies
Humans
Sjogren's syndrome
rheumatoid
Arthritis
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License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23271
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 8087347560022d11cb0-72ff-48c3-bd85-08c1a596208b19474778600166eaeab-185a-4c9b-9233-24d7f52b09942020-05-26T00:00:47Z2020-05-26T00:00:47Z2019Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2  = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p  and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation.application/pdfhttps://doi.org/10.1080/03009742.2018.14691641502773203009742https://repository.urosario.edu.co/handle/10336/23271engTaylor and Francis Ltd163No. 2157Scandinavian Journal of RheumatologyVol. 48Scandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCyclic citrullinated peptide antibodyImmunoglobulin gCyclic citrullinated peptide antibodyArthritisArthropathyArticleCochrane libraryHumanMedlinePriority journalRheumatoid arthritisSjoegren syndromeSynovitisSystematic reviewWeb of scienceComplicationImmunologyMeta analysisSjoegren syndromeAnti-citrullinated protein antibodiesHumansSjogren's syndromerheumatoidArthritisAnti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Molano González, NicolásOlivares-Martínez E.Anaya, Juan-ManuelHernández-Molina G.10336/23271oai:repository.urosario.edu.co:10336/232712022-05-02 07:37:16.737223https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
title Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
spellingShingle Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
Cyclic citrullinated peptide antibody
Immunoglobulin g
Cyclic citrullinated peptide antibody
Arthritis
Arthropathy
Article
Cochrane library
Human
Medline
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Synovitis
Systematic review
Web of science
Complication
Immunology
Meta analysis
Sjoegren syndrome
Anti-citrullinated protein antibodies
Humans
Sjogren's syndrome
rheumatoid
Arthritis
title_short Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
title_full Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
title_fullStr Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
title_full_unstemmed Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
title_sort Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
dc.subject.keyword.spa.fl_str_mv Cyclic citrullinated peptide antibody
Immunoglobulin g
Cyclic citrullinated peptide antibody
Arthritis
Arthropathy
Article
Cochrane library
Human
Medline
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Synovitis
Systematic review
Web of science
Complication
Immunology
Meta analysis
Sjoegren syndrome
Anti-citrullinated protein antibodies
Humans
Sjogren's syndrome
topic Cyclic citrullinated peptide antibody
Immunoglobulin g
Cyclic citrullinated peptide antibody
Arthritis
Arthropathy
Article
Cochrane library
Human
Medline
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Synovitis
Systematic review
Web of science
Complication
Immunology
Meta analysis
Sjoegren syndrome
Anti-citrullinated protein antibodies
Humans
Sjogren's syndrome
rheumatoid
Arthritis
dc.subject.keyword.eng.fl_str_mv rheumatoid
Arthritis
description Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2  = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p  and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation.
publishDate 2019
dc.date.created.spa.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:00:47Z
dc.date.available.none.fl_str_mv 2020-05-26T00:00:47Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1080/03009742.2018.1469164
dc.identifier.issn.none.fl_str_mv 15027732
03009742
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23271
url https://doi.org/10.1080/03009742.2018.1469164
https://repository.urosario.edu.co/handle/10336/23271
identifier_str_mv 15027732
03009742
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 163
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 157
dc.relation.citationTitle.none.fl_str_mv Scandinavian Journal of Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 48
dc.relation.ispartof.spa.fl_str_mv Scandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Taylor and Francis Ltd
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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