Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23271
- Acceso en línea:
- https://doi.org/10.1080/03009742.2018.1469164
https://repository.urosario.edu.co/handle/10336/23271
- Palabra clave:
- Cyclic citrullinated peptide antibody
Immunoglobulin g
Cyclic citrullinated peptide antibody
Arthritis
Arthropathy
Article
Cochrane library
Human
Medline
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Synovitis
Systematic review
Web of science
Complication
Immunology
Meta analysis
Sjoegren syndrome
Anti-citrullinated protein antibodies
Humans
Sjogren's syndrome
rheumatoid
Arthritis
- Rights
- License
- Abierto (Texto Completo)
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Repositorio EdocUR - U. Rosario |
repository_id_str |
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spelling |
8087347560022d11cb0-72ff-48c3-bd85-08c1a596208b19474778600166eaeab-185a-4c9b-9233-24d7f52b09942020-05-26T00:00:47Z2020-05-26T00:00:47Z2019Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2 = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation.application/pdfhttps://doi.org/10.1080/03009742.2018.14691641502773203009742https://repository.urosario.edu.co/handle/10336/23271engTaylor and Francis Ltd163No. 2157Scandinavian Journal of RheumatologyVol. 48Scandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCyclic citrullinated peptide antibodyImmunoglobulin gCyclic citrullinated peptide antibodyArthritisArthropathyArticleCochrane libraryHumanMedlinePriority journalRheumatoid arthritisSjoegren syndromeSynovitisSystematic reviewWeb of scienceComplicationImmunologyMeta analysisSjoegren syndromeAnti-citrullinated protein antibodiesHumansSjogren's syndromerheumatoidArthritisAnti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Molano González, NicolásOlivares-Martínez E.Anaya, Juan-ManuelHernández-Molina G.10336/23271oai:repository.urosario.edu.co:10336/232712022-05-02 07:37:16.737223https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
title |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
spellingShingle |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis Cyclic citrullinated peptide antibody Immunoglobulin g Cyclic citrullinated peptide antibody Arthritis Arthropathy Article Cochrane library Human Medline Priority journal Rheumatoid arthritis Sjoegren syndrome Synovitis Systematic review Web of science Complication Immunology Meta analysis Sjoegren syndrome Anti-citrullinated protein antibodies Humans Sjogren's syndrome rheumatoid Arthritis |
title_short |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
title_full |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
title_fullStr |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
title_full_unstemmed |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
title_sort |
Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis |
dc.subject.keyword.spa.fl_str_mv |
Cyclic citrullinated peptide antibody Immunoglobulin g Cyclic citrullinated peptide antibody Arthritis Arthropathy Article Cochrane library Human Medline Priority journal Rheumatoid arthritis Sjoegren syndrome Synovitis Systematic review Web of science Complication Immunology Meta analysis Sjoegren syndrome Anti-citrullinated protein antibodies Humans Sjogren's syndrome |
topic |
Cyclic citrullinated peptide antibody Immunoglobulin g Cyclic citrullinated peptide antibody Arthritis Arthropathy Article Cochrane library Human Medline Priority journal Rheumatoid arthritis Sjoegren syndrome Synovitis Systematic review Web of science Complication Immunology Meta analysis Sjoegren syndrome Anti-citrullinated protein antibodies Humans Sjogren's syndrome rheumatoid Arthritis |
dc.subject.keyword.eng.fl_str_mv |
rheumatoid Arthritis |
description |
Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2 = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation. |
publishDate |
2019 |
dc.date.created.spa.fl_str_mv |
2019 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:00:47Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:00:47Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1080/03009742.2018.1469164 |
dc.identifier.issn.none.fl_str_mv |
15027732 03009742 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23271 |
url |
https://doi.org/10.1080/03009742.2018.1469164 https://repository.urosario.edu.co/handle/10336/23271 |
identifier_str_mv |
15027732 03009742 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
163 |
dc.relation.citationIssue.none.fl_str_mv |
No. 2 |
dc.relation.citationStartPage.none.fl_str_mv |
157 |
dc.relation.citationTitle.none.fl_str_mv |
Scandinavian Journal of Rheumatology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 48 |
dc.relation.ispartof.spa.fl_str_mv |
Scandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Taylor and Francis Ltd |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167526948470784 |