Factors influencing polyautoimmunity in systemic lupus erythematosus

Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lu...

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Autores:
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23389
Acceso en línea:
https://doi.org/10.1016/j.autrev.2009.10.001
https://repository.urosario.edu.co/handle/10336/23389
Palabra clave:
Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
autoimmune
systemic
Lupus erythematosus
Thyroiditis
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23389
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Factors influencing polyautoimmunity in systemic lupus erythematosus
title Factors influencing polyautoimmunity in systemic lupus erythematosus
spellingShingle Factors influencing polyautoimmunity in systemic lupus erythematosus
Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
autoimmune
systemic
Lupus erythematosus
Thyroiditis
title_short Factors influencing polyautoimmunity in systemic lupus erythematosus
title_full Factors influencing polyautoimmunity in systemic lupus erythematosus
title_fullStr Factors influencing polyautoimmunity in systemic lupus erythematosus
title_full_unstemmed Factors influencing polyautoimmunity in systemic lupus erythematosus
title_sort Factors influencing polyautoimmunity in systemic lupus erythematosus
dc.subject.keyword.spa.fl_str_mv Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
topic Ribonucleoprotein antibody
Ro antibody
Antiphospholipid syndrome
Autoimmune thyroiditis
Autoimmunity
Clinical feature
Cluster analysis
Cross-sectional study
Disease association
Disease predisposition
Human
Pathophysiology
Phenotype
Review
Risk factor
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Autoantibodies
Autoimmunity
Cross-sectional studies
Ethnic groups
Female
Humans
Male
Multivariate analysis
Prevalence
Risk factors
Sjogren's syndrome
Familial autoimmunity
Multiple autoimmune syndrome
Polyautoimmunity
Systemic lupus erythematosus
autoimmune
systemic
Lupus erythematosus
Thyroiditis
dc.subject.keyword.eng.fl_str_mv autoimmune
systemic
Lupus erythematosus
Thyroiditis
description Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.
publishDate 2010
dc.date.created.spa.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:01:37Z
dc.date.available.none.fl_str_mv 2020-05-26T00:01:37Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.autrev.2009.10.001
dc.identifier.issn.none.fl_str_mv 15689972
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23389
url https://doi.org/10.1016/j.autrev.2009.10.001
https://repository.urosario.edu.co/handle/10336/23389
identifier_str_mv 15689972
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 232
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 229
dc.relation.citationTitle.none.fl_str_mv Autoimmunity Reviews
dc.relation.citationVolume.none.fl_str_mv Vol. 9
dc.relation.ispartof.spa.fl_str_mv Autoimmunity Reviews, ISSN:15689972, Vol.9, No.4 (2010); pp. 229-232
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spelling 5224970160052896057600cf4cb39c-a593-428d-aa2b-a2882479a103983cd9aa-c4c1-4c16-bb3c-8bc108612c5bb1bde409-6d28-4d69-af53-a7f94056ce3cab7e3e14-43e1-4674-adc9-dca2487fd9b655e9af6d-30cd-435d-88af-c069a9fcaabc81a96fdd-8518-4107-a9f7-d694722ae72a194747786002020-05-26T00:01:37Z2020-05-26T00:01:37Z2010Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.application/pdfhttps://doi.org/10.1016/j.autrev.2009.10.00115689972https://repository.urosario.edu.co/handle/10336/23389eng232No. 4229Autoimmunity ReviewsVol. 9Autoimmunity Reviews, ISSN:15689972, Vol.9, No.4 (2010); pp. 229-232https://www.scopus.com/inward/record.uri?eid=2-s2.0-73849127374&doi=10.1016%2fj.autrev.2009.10.001&partnerID=40&md5=7309cbdf99523babdb0501b6104105a2Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURRibonucleoprotein antibodyRo antibodyAntiphospholipid syndromeAutoimmune thyroiditisAutoimmunityClinical featureCluster analysisCross-sectional studyDisease associationDisease predispositionHumanPathophysiologyPhenotypeReviewRisk factorSex differenceSjoegren syndromeSystemic lupus erythematosusAutoantibodiesAutoimmunityCross-sectional studiesEthnic groupsFemaleHumansMaleMultivariate analysisPrevalenceRisk factorsSjogren's syndromeFamilial autoimmunityMultiple autoimmune syndromePolyautoimmunitySystemic lupus erythematosusautoimmunesystemicLupus erythematosusThyroiditisFactors influencing polyautoimmunity in systemic lupus erythematosusarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas-Villarraga, AdrianaDuarte-Rey, CarolinaToro, Carlos-EnriqueEspinosa, GerardRodríguez-Velosa, YolimaMantilla, Rubén D.Iglesias-Gamarra, AntonioCervera, RicardAnaya, Juan-ManuelORIGINALFactors_influencing_polyautoimmunity_in.pdfapplication/pdf241383https://repository.urosario.edu.co/bitstreams/3cbb74fd-e1d8-4987-aedb-7e6a84cdc5f6/download162f18fd7520a9cac6c0c9e6a090f7c6MD51TEXTFactors_influencing_polyautoimmunity_in.pdf.txtFactors_influencing_polyautoimmunity_in.pdf.txtExtracted texttext/plain24035https://repository.urosario.edu.co/bitstreams/27264b17-de7b-45e9-b68b-9bde864c6a71/download7f610c0c070b53a5383c6ef8c22f577aMD52THUMBNAILFactors_influencing_polyautoimmunity_in.pdf.jpgFactors_influencing_polyautoimmunity_in.pdf.jpgGenerated Thumbnailimage/jpeg3836https://repository.urosario.edu.co/bitstreams/2bc410cf-8bce-4b2b-b426-25966a19620b/download43d79e02490924e4111625c6b1011232MD5310336/23389oai:repository.urosario.edu.co:10336/233892022-05-02 07:37:13.575668https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co