What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?

Malaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by P. vivax. © 2017 López, Yepes-Pérez, Hincapié-Escobar, Díaz-Arévalo and Patarroyo.

• Fecha de publicación: 2017
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24090
• Acceso en línea: https://doi.org/10.3389/fimmu.2017.00126; https://repository.urosario.edu.co/handle/10336/24090
• Palabra clave: Apical membrane antigen 1; Chemokine; Circumsporozoite protein; Duffy binding protein; Malaria vaccine; Merozoite surface protein 3; Merozoite surface protein 9; Protozoal protein; Recombinant protein; Synthetic peptide; Transcription factor; Unclassified drug; Adaptive immunity; Antigen binding; B lymphocyte; Cell invasion; Disease severity; Geographic distribution; Helper cell; Host cell; Human; Immune response; Immunological tolerance; Inflammation; Innate immunity; Macrophage activation; Minor histocompatibility complex; Natural killer cell; Neuromuscular blocking; Nonhuman; Pathogenesis; Phagolysosome; Plasmodium vivax malaria; Review; Serology; Sporozoite; T lymphocyte activation; Vaccine immunogenicity; Antigenicity; Immune response; Immunogenicity; Malaria; Plasmodium vivax
• License: Abierto (Texto Completo)