Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in t...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26738
Acceso en línea:
https://doi.org/10.1016/j.peptides.2006.02.001
https://repository.urosario.edu.co/handle/10336/26738
Palabra clave:
Invasion
Receptor
Ligand
Plasmodium falciparum
Vaccine
MSP-6
Binding
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_63374c1b506b83d47d31d8c89c86f407
oai_identifier_str oai:repository.urosario.edu.co:10336/26738
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 2545c992-99b1-4106-8dc9-0a8d111b2438-14255e3fa-2b0d-47ce-ab18-c66a1b12d04d-1ef6547b6-3130-435a-8a09-7ca050cd7b64-134b82e95-53e0-4ba5-a5c5-d4191164afa1-191225589-1eba5265c-2b9f-49a4-8c8c-4e3459a41e19-1a4e7ff19-544a-44fe-ad9c-61d4aff3b8ba-1b66a89f6-d95a-4a3d-95bb-e83882414b37-110ecd4f9-843f-4ef2-bec0-7d39d3381a13-1518488266002020-08-19T14:40:09Z2020-08-19T14:40:09Z2006-07This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 ?g ml?1 concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.application/pdfhttps://doi.org/10.1016/j.peptides.2006.02.001ISSN: 0196-9781EISSN: 1873-5169https://repository.urosario.edu.co/handle/10336/26738engElsevier1692No. 71685PeptidesVol. 27Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.27, No.7 (2006); pp. 1685-1692 https://www.sciencedirect.com/science/article/abs/pii/S0196978106000763Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecPeptidesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURInvasionReceptorLigandPlasmodium falciparumVaccineMSP-6BindingPlasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasionLos péptidos derivados de la proteína de superficie 6 del merozoito de Plasmodium falciparum (MSP-6) se unen a los eritrocitos e inhiben parcialmente la invasión del parásitoarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501López, RamsésValbuena, JohnRodríguez, Luis E.Vera, RicardoCurtidor, HernandoPuentes, AlvaroGarcía, JavierRamirez, Luis E.Patarroyo, Manuel E.Ocampo, Marisol10336/26738oai:repository.urosario.edu.co:10336/267382021-06-03 00:49:58.712https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
dc.title.TranslatedTitle.spa.fl_str_mv Los péptidos derivados de la proteína de superficie 6 del merozoito de Plasmodium falciparum (MSP-6) se unen a los eritrocitos e inhiben parcialmente la invasión del parásito
title Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
spellingShingle Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
Invasion
Receptor
Ligand
Plasmodium falciparum
Vaccine
MSP-6
Binding
title_short Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
title_full Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
title_fullStr Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
title_full_unstemmed Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
title_sort Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion
dc.subject.keyword.spa.fl_str_mv Invasion
Receptor
Ligand
Plasmodium falciparum
Vaccine
MSP-6
Binding
topic Invasion
Receptor
Ligand
Plasmodium falciparum
Vaccine
MSP-6
Binding
description This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 ?g ml?1 concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.
publishDate 2006
dc.date.created.spa.fl_str_mv 2006-07
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:09Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:09Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.peptides.2006.02.001
dc.identifier.issn.none.fl_str_mv ISSN: 0196-9781
EISSN: 1873-5169
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26738
url https://doi.org/10.1016/j.peptides.2006.02.001
https://repository.urosario.edu.co/handle/10336/26738
identifier_str_mv ISSN: 0196-9781
EISSN: 1873-5169
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1692
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 1685
dc.relation.citationTitle.none.fl_str_mv Peptides
dc.relation.citationVolume.none.fl_str_mv Vol. 27
dc.relation.ispartof.spa.fl_str_mv Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.27, No.7 (2006); pp. 1685-1692
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0196978106000763
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Peptides
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167436308512768

Publicaciones similares