Correlation between arterial lactate and central venous lactate in children with sepsis

Introduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospecti...

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Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
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oai:repository.urosario.edu.co:10336/19004
Acceso en línea:
http://repository.urosario.edu.co/handle/10336/19004
Palabra clave:
Enfermedades
Septicemia
Sepsis
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Abierto (Texto Completo)
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spelling 81cbcb91-7621-4b47-9c70-634fa08d1bd260017033937-ca42-45ae-8beb-ac27e0b56f606004ac580a5-3fea-4b5f-ba84-30b7d1ef99a160053a80ca5-99b4-4b19-95d4-56b487d69e8b600cae61c7a-2235-41c8-a07e-23458645bdf66006568ef5c-74ac-465b-9249-cd9a2be0b3826002019-02-04T17:40:31Z2019-02-04T17:40:31Z20162016Introduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospective observational study. Forty-two patients were included between the age of 1 month and 17 years, with a diagnosis of sepsis and septic shock, who were admitted to the intensive care unit of a university referral hospital. The lactate value obtained from an arterial blood sample and a central venous blood sample drawn simultaneously, and within 24 hours of admission to the unit, was recorded. Results. The median age was 2.3 years (RIC 0,3-15), with a predominance of males (71.4%), having a 2.5: 1 ratio to females. Most of the patients had septic shock (78.5%) of pulmonary origin (50.0%), followed by those of gastrointestinal origin (26.1%). Using Spearman's Rho, a 0.872 (p<0.001) correlation was found between arterial and venous lactate, which did not vary when adjusted for age (p<0.05) and the use of vasoactive drugs (p<0.05). Conclusion. There is a good correlation between arterial and venous lactate in pediatric patients with sepsis and septic shock, which is not affected by demographic variables or type of vasoactive support. Copyright © 2016 Jaime Fernández Sarmiento et al.application/pdfISSN 2090-1305http://repository.urosario.edu.co/handle/10336/19004engCritical Care Research and PracticeVol. 2016Critical Care Research and Practice, ISSN: 2090-1305, Vol. 2016 (2016)http://downloads.hindawi.com/journals/ccrp/2016/7839739.pdfAbierto (Texto Completo)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2Nascente, A.P.M., Assunção, M., Guedes, C.J., Comparison of lactate values obtained from different sites and their clinical significance in patients with severe sepsis (2011) Sao Paulo Medical Journal, 129 (1), pp. 11-16instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedades616600SepticemiaSepsisCorrelation between arterial lactate and central venous lactate in children with sepsisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Fernández Sarmiento, JaimeAraque, PaulaYepes, MaríaMulett, HernandoTovar, XimenaRodriguez, FabioFernández Sarmiento, JaimeAraque, PaulaYepes, MaríaMulett, HernandoTovar, XimenaRodriguez, FabioORIGINAL72.pdfapplication/pdf1356156https://repository.urosario.edu.co/bitstreams/7e61cde2-5370-4f2c-bdd0-4e8b76b3dda0/download88a7253fecc6cff5b58b28be2fb7adbaMD51TEXT72.pdf.txt72.pdf.txtExtracted texttext/plain23247https://repository.urosario.edu.co/bitstreams/0d1c4236-1598-42bf-837b-b226910caf6f/download12d931634b7fd0bb8ab475f1c6478713MD52THUMBNAIL72.pdf.jpg72.pdf.jpgGenerated Thumbnailimage/jpeg4228https://repository.urosario.edu.co/bitstreams/3eba779a-69cb-4914-a268-75249177bf03/downloadd817669c44c1c29edf469473a667fbf6MD5310336/19004oai:repository.urosario.edu.co:10336/190042019-09-19 07:37:54.609585https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Correlation between arterial lactate and central venous lactate in children with sepsis
title Correlation between arterial lactate and central venous lactate in children with sepsis
spellingShingle Correlation between arterial lactate and central venous lactate in children with sepsis
Enfermedades
Septicemia
Sepsis
title_short Correlation between arterial lactate and central venous lactate in children with sepsis
title_full Correlation between arterial lactate and central venous lactate in children with sepsis
title_fullStr Correlation between arterial lactate and central venous lactate in children with sepsis
title_full_unstemmed Correlation between arterial lactate and central venous lactate in children with sepsis
title_sort Correlation between arterial lactate and central venous lactate in children with sepsis
dc.subject.ddc.spa.fl_str_mv Enfermedades
topic Enfermedades
Septicemia
Sepsis
dc.subject.lemb.spa.fl_str_mv Septicemia
Sepsis
description Introduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospective observational study. Forty-two patients were included between the age of 1 month and 17 years, with a diagnosis of sepsis and septic shock, who were admitted to the intensive care unit of a university referral hospital. The lactate value obtained from an arterial blood sample and a central venous blood sample drawn simultaneously, and within 24 hours of admission to the unit, was recorded. Results. The median age was 2.3 years (RIC 0,3-15), with a predominance of males (71.4%), having a 2.5: 1 ratio to females. Most of the patients had septic shock (78.5%) of pulmonary origin (50.0%), followed by those of gastrointestinal origin (26.1%). Using Spearman's Rho, a 0.872 (p<0.001) correlation was found between arterial and venous lactate, which did not vary when adjusted for age (p<0.05) and the use of vasoactive drugs (p<0.05). Conclusion. There is a good correlation between arterial and venous lactate in pediatric patients with sepsis and septic shock, which is not affected by demographic variables or type of vasoactive support. Copyright © 2016 Jaime Fernández Sarmiento et al.
publishDate 2016
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dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2019-02-04T17:40:31Z
dc.date.available.none.fl_str_mv 2019-02-04T17:40:31Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN 2090-1305
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identifier_str_mv ISSN 2090-1305
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dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationTitle.none.fl_str_mv Critical Care Research and Practice
dc.relation.citationVolume.none.fl_str_mv Vol. 2016
dc.relation.ispartof.spa.fl_str_mv Critical Care Research and Practice, ISSN: 2090-1305, Vol. 2016 (2016)
dc.relation.uri.spa.fl_str_mv http://downloads.hindawi.com/journals/ccrp/2016/7839739.pdf
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rights_invalid_str_mv Abierto (Texto Completo)
https://creativecommons.org/licenses/by/4.0/
http://purl.org/coar/access_right/c_abf2
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institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Nascente, A.P.M., Assunção, M., Guedes, C.J., Comparison of lactate values obtained from different sites and their clinical significance in patients with severe sepsis (2011) Sao Paulo Medical Journal, 129 (1), pp. 11-16
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