Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects

Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects...

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Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27477
Acceso en línea:
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014
https://repository.urosario.edu.co/handle/10336/27477
Palabra clave:
Brain-derived neurotrophic factor
Stroke
Neuronal plasticity
Rehabilitation
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Restringido (Acceso a grupos específicos)
id EDOCUR2_61fdd3ccea39bea3d46d6e7c70c24f56
oai_identifier_str oai:repository.urosario.edu.co:10336/27477
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling f6d57018-2d18-435d-92cf-75088d3f5580-1cd50225d-c5c9-4250-810c-efe25addf370-15f3cab98-7fea-4e82-92b3-e533fc735318-10490813e-d145-4b19-b71d-0efbeb38853b-110101687956002020-08-19T14:42:22Z2020-08-19T14:42:22Z2016-12-01Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL. Methods Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay. Results Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P?<?.01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P?>?.05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence. Conclusion Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life.application/pdfhttps://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014ISSN: 1052-3057EISSN: 1532-8511https://repository.urosario.edu.co/handle/10336/27477engElsevier2974No. 122968Journal of Stroke and Cerebrovascular DiseasesVol. 25Journal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057;EISSN: 1532-8511 Vol.25, No.12 (2016); pp. 2968-2974https://www.sciencedirect.com/science/article/abs/pii/S1052305716302865Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Stroke and Cerebrovascular Diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBrain-derived neurotrophic factorStrokeNeuronal plasticityRehabilitationDecreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjectsDisminución de las concentraciones séricas del factor neurotrófico derivado del cerebro en sujetos crónicos después de un accidente cerebrovasculararticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Lopes Santos, GabrielaCarmona Alcântara, CarolinaAbreu Silva-Couto, MarcelaRusso, Thiago LuizGarcía Salazar, Luisa Fernanda10336/27477oai:repository.urosario.edu.co:10336/274772022-05-02 07:37:21.915753https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
dc.title.TranslatedTitle.spa.fl_str_mv Disminución de las concentraciones séricas del factor neurotrófico derivado del cerebro en sujetos crónicos después de un accidente cerebrovascular
title Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
spellingShingle Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
Brain-derived neurotrophic factor
Stroke
Neuronal plasticity
Rehabilitation
title_short Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
title_full Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
title_fullStr Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
title_full_unstemmed Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
title_sort Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
dc.subject.keyword.spa.fl_str_mv Brain-derived neurotrophic factor
Stroke
Neuronal plasticity
Rehabilitation
topic Brain-derived neurotrophic factor
Stroke
Neuronal plasticity
Rehabilitation
description Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL. Methods Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay. Results Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P?<?.01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P?>?.05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence. Conclusion Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life.
publishDate 2016
dc.date.created.spa.fl_str_mv 2016-12-01
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:42:22Z
dc.date.available.none.fl_str_mv 2020-08-19T14:42:22Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014
dc.identifier.issn.none.fl_str_mv ISSN: 1052-3057
EISSN: 1532-8511
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27477
url https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014
https://repository.urosario.edu.co/handle/10336/27477
identifier_str_mv ISSN: 1052-3057
EISSN: 1532-8511
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 2974
dc.relation.citationIssue.none.fl_str_mv No. 12
dc.relation.citationStartPage.none.fl_str_mv 2968
dc.relation.citationTitle.none.fl_str_mv Journal of Stroke and Cerebrovascular Diseases
dc.relation.citationVolume.none.fl_str_mv Vol. 25
dc.relation.ispartof.spa.fl_str_mv Journal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057;EISSN: 1532-8511 Vol.25, No.12 (2016); pp. 2968-2974
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S1052305716302865
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Journal of Stroke and Cerebrovascular Diseases
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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