Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects
Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2016
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27477
- Acceso en línea:
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014
https://repository.urosario.edu.co/handle/10336/27477
- Palabra clave:
- Brain-derived neurotrophic factor
Stroke
Neuronal plasticity
Rehabilitation
- Rights
- License
- Restringido (Acceso a grupos específicos)
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f6d57018-2d18-435d-92cf-75088d3f5580-1cd50225d-c5c9-4250-810c-efe25addf370-15f3cab98-7fea-4e82-92b3-e533fc735318-10490813e-d145-4b19-b71d-0efbeb38853b-110101687956002020-08-19T14:42:22Z2020-08-19T14:42:22Z2016-12-01Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL. Methods Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay. Results Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P?<?.01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P?>?.05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence. Conclusion Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life.application/pdfhttps://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014ISSN: 1052-3057EISSN: 1532-8511https://repository.urosario.edu.co/handle/10336/27477engElsevier2974No. 122968Journal of Stroke and Cerebrovascular DiseasesVol. 25Journal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057;EISSN: 1532-8511 Vol.25, No.12 (2016); pp. 2968-2974https://www.sciencedirect.com/science/article/abs/pii/S1052305716302865Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Stroke and Cerebrovascular Diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBrain-derived neurotrophic factorStrokeNeuronal plasticityRehabilitationDecreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjectsDisminución de las concentraciones séricas del factor neurotrófico derivado del cerebro en sujetos crónicos después de un accidente cerebrovasculararticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Lopes Santos, GabrielaCarmona Alcântara, CarolinaAbreu Silva-Couto, MarcelaRusso, Thiago LuizGarcía Salazar, Luisa Fernanda10336/27477oai:repository.urosario.edu.co:10336/274772022-05-02 07:37:21.915753https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
dc.title.TranslatedTitle.spa.fl_str_mv |
Disminución de las concentraciones séricas del factor neurotrófico derivado del cerebro en sujetos crónicos después de un accidente cerebrovascular |
title |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
spellingShingle |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects Brain-derived neurotrophic factor Stroke Neuronal plasticity Rehabilitation |
title_short |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
title_full |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
title_fullStr |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
title_full_unstemmed |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
title_sort |
Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects |
dc.subject.keyword.spa.fl_str_mv |
Brain-derived neurotrophic factor Stroke Neuronal plasticity Rehabilitation |
topic |
Brain-derived neurotrophic factor Stroke Neuronal plasticity Rehabilitation |
description |
Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL. Methods Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay. Results Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P?<?.01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P?>?.05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence. Conclusion Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life. |
publishDate |
2016 |
dc.date.created.spa.fl_str_mv |
2016-12-01 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:42:22Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:42:22Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 1052-3057 EISSN: 1532-8511 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27477 |
url |
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014 https://repository.urosario.edu.co/handle/10336/27477 |
identifier_str_mv |
ISSN: 1052-3057 EISSN: 1532-8511 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
2974 |
dc.relation.citationIssue.none.fl_str_mv |
No. 12 |
dc.relation.citationStartPage.none.fl_str_mv |
2968 |
dc.relation.citationTitle.none.fl_str_mv |
Journal of Stroke and Cerebrovascular Diseases |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 25 |
dc.relation.ispartof.spa.fl_str_mv |
Journal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057;EISSN: 1532-8511 Vol.25, No.12 (2016); pp. 2968-2974 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S1052305716302865 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.source.spa.fl_str_mv |
Journal of Stroke and Cerebrovascular Diseases |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167576093130752 |