Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorph...

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Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23684
Acceso en línea:
https://doi.org/10.1016/j.clim.2016.04.002
https://repository.urosario.edu.co/handle/10336/23684
Palabra clave:
Article
Controlled study
Fluorescence
Gender
Human
Klinefelter syndrome
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
X chromosome
Y chromosome
Clinical trial
Female
Gene frequency
Genetics
Genotype
Klinefelter syndrome
Multicenter study
Sjoegren syndrome
Female
Gene Frequency
Genotype
Humans
Klinefelter Syndrome
Male
Sjogren's Syndrome
Klinefelter's syndrome
Sex bias
Sjögren's syndrome
X chromosome
Systemic
Human
Single Nucleotide
Rheumatoid
Human
X
Y
Arthritis
Chromosomes
Chromosomes
Lupus Erythematosus
Polymorphism
Rights
License
Abierto (Texto Completo)
Description
Summary:Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p = 0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. © 2016.