Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. © 2007 Blackwell Munksgaard.

• Fecha de publicación: 2007
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23386
• Acceso en línea: https://doi.org/10.1111/j.1399-0039.2007.00843.x; https://repository.urosario.edu.co/handle/10336/23386
• Palabra clave: Macrophage migration inhibition factor; Adult; Article; Colombia; Controlled study; Female; Genetic association; Genetic risk; Human; Human immunodeficiency virus infection; Infection risk; Lung tuberculosis; Major clinical study; Male; Microsatellite marker; Multivariate analysis; Priority journal; Single nucleotide polymorphism; Tuberculin test; Alleles; Case-control studies; Colombia; Confidence intervals; Female; Genetic predisposition to disease; Geography; Humans; Macrophage migration-inhibitory factors; Male; Microsatellite repeats; Odds ratio; Population groups; Risk factors; Tuberculin test; Human immunodeficiency virus; Delayed-type hypersensitivity; Microsatellite; Mif; Polymorphism; Single nucleotide polymorphism; Tuberculin skin test; Tuberculosis; human; single nucleotide; pulmonary; pair 22; Chromosomes; Polymorphism; Tuberculosis
• License: Abierto (Texto Completo)