A review of blood diseases and cytopenias associated with human parvovirus B19 infection

Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages ha...

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Fecha de publicación:: 2015

Institución:: Universidad del Rosario

Repositorio:: Repositorio EdocUR - U. Rosario

Idioma:: eng

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spelling	404187f1-16b5-496a-a7db-5918a0c5e4c6-12020-05-25T23:58:56Z2020-05-25T23:58:56Z2015Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describes the current state of knowledge of the abnormalities of individual blood cell lineages encountered during parvovirus B19 infection, over the almost 40years since its discovery, and reveals some very interesting themes, which improve our understanding of the pathogenesis of B19 infection with particular reference to the bone marrow. © 2015 John Wiley and Sons, Ltd.application/pdfhttps://doi.org/10.1002/rmv.18391052927610991654https://repository.urosario.edu.co/handle/10336/22952engJohn Wiley and Sons Ltd240No. 4224Reviews in Medical VirologyVol. 25Reviews in Medical Virology, ISSN:10529276, 10991654, Vol.25, No.4 (2015); pp. 224-240https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935748846&doi=10.1002%2frmv.1839&partnerID=40&md5=96ec3ab925a66563eae364d28c626c23Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHemoglobinImmunoglobulin gImmunoglobulin mAntigen antibody complexAplastic anemiaArthralgiaArthritisBone marrowBone marrow necrosisCell lineageChillCytopeniaDna repairErythema infectiosumErythrophagocytosisGranulocyteHeadacheHematologic diseaseHemophagocytic syndromeHumanHuman parvovirus b19ImmunologyLymphocyteMacrophageMegakaryocyteMonocyteMyalgiaMyelodysplastic syndromeMyelophthisic anemiaNeutrophilNonhumanPathogenesisPetechiaPruritusRashReticulocyteReviewTemperatureThrombocyteThrombocytopeniaVirus excretionVirus replicationComplicationHematologic diseaseIsolation and purificationParvovirus infectionVirologyHematologic diseasesHumansParvoviridae infectionshumanParvovirus b19A review of blood diseases and cytopenias associated with human parvovirus B19 infectionarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Kerr, Jonathan R.10336/22952oai:repository.urosario.edu.co:10336/229522022-05-02 07:37:20.692079https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
title	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
spellingShingle	A review of blood diseases and cytopenias associated with human parvovirus B19 infection Hemoglobin Immunoglobulin g Immunoglobulin m Antigen antibody complex Aplastic anemia Arthralgia Arthritis Bone marrow Bone marrow necrosis Cell lineage Chill Cytopenia Dna repair Erythema infectiosum Erythrophagocytosis Granulocyte Headache Hematologic disease Hemophagocytic syndrome Human Human parvovirus b19 Immunology Lymphocyte Macrophage Megakaryocyte Monocyte Myalgia Myelodysplastic syndrome Myelophthisic anemia Neutrophil Nonhuman Pathogenesis Petechia Pruritus Rash Reticulocyte Review Temperature Thrombocyte Thrombocytopenia Virus excretion Virus replication Complication Hematologic disease Isolation and purification Parvovirus infection Virology Hematologic diseases Humans Parvoviridae infections human Parvovirus b19
title_short	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
title_full	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
title_fullStr	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
title_full_unstemmed	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
title_sort	A review of blood diseases and cytopenias associated with human parvovirus B19 infection
dc.subject.keyword.spa.fl_str_mv	Hemoglobin Immunoglobulin g Immunoglobulin m Antigen antibody complex Aplastic anemia Arthralgia Arthritis Bone marrow Bone marrow necrosis Cell lineage Chill Cytopenia Dna repair Erythema infectiosum Erythrophagocytosis Granulocyte Headache Hematologic disease Hemophagocytic syndrome Human Human parvovirus b19 Immunology Lymphocyte Macrophage Megakaryocyte Monocyte Myalgia Myelodysplastic syndrome Myelophthisic anemia Neutrophil Nonhuman Pathogenesis Petechia Pruritus Rash Reticulocyte Review Temperature Thrombocyte Thrombocytopenia Virus excretion Virus replication Complication Hematologic disease Isolation and purification Parvovirus infection Virology Hematologic diseases Humans Parvoviridae infections
topic	Hemoglobin Immunoglobulin g Immunoglobulin m Antigen antibody complex Aplastic anemia Arthralgia Arthritis Bone marrow Bone marrow necrosis Cell lineage Chill Cytopenia Dna repair Erythema infectiosum Erythrophagocytosis Granulocyte Headache Hematologic disease Hemophagocytic syndrome Human Human parvovirus b19 Immunology Lymphocyte Macrophage Megakaryocyte Monocyte Myalgia Myelodysplastic syndrome Myelophthisic anemia Neutrophil Nonhuman Pathogenesis Petechia Pruritus Rash Reticulocyte Review Temperature Thrombocyte Thrombocytopenia Virus excretion Virus replication Complication Hematologic disease Isolation and purification Parvovirus infection Virology Hematologic diseases Humans Parvoviridae infections human Parvovirus b19
dc.subject.keyword.eng.fl_str_mv	human Parvovirus b19
description	Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describes the current state of knowledge of the abnormalities of individual blood cell lineages encountered during parvovirus B19 infection, over the almost 40years since its discovery, and reveals some very interesting themes, which improve our understanding of the pathogenesis of B19 infection with particular reference to the bone marrow. © 2015 John Wiley and Sons, Ltd.
publishDate	2015
dc.date.created.spa.fl_str_mv	2015
dc.date.accessioned.none.fl_str_mv	2020-05-25T23:58:56Z
dc.date.available.none.fl_str_mv	2020-05-25T23:58:56Z
dc.type.eng.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv	Artículo
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1002/rmv.1839
dc.identifier.issn.none.fl_str_mv	10529276 10991654
dc.identifier.uri.none.fl_str_mv	https://repository.urosario.edu.co/handle/10336/22952
url	https://doi.org/10.1002/rmv.1839 https://repository.urosario.edu.co/handle/10336/22952
identifier_str_mv	10529276 10991654
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.relation.citationEndPage.none.fl_str_mv	240
dc.relation.citationIssue.none.fl_str_mv	No. 4
dc.relation.citationStartPage.none.fl_str_mv	224
dc.relation.citationTitle.none.fl_str_mv	Reviews in Medical Virology
dc.relation.citationVolume.none.fl_str_mv	Vol. 25
dc.relation.ispartof.spa.fl_str_mv	Reviews in Medical Virology, ISSN:10529276, 10991654, Vol.25, No.4 (2015); pp. 224-240
dc.relation.uri.spa.fl_str_mv	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935748846&doi=10.1002%2frmv.1839&partnerID=40&md5=96ec3ab925a66563eae364d28c626c23
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv	Abierto (Texto Completo)
rights_invalid_str_mv	Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	John Wiley and Sons Ltd
institution	Universidad del Rosario
dc.source.instname.spa.fl_str_mv	instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv	reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv	Repositorio institucional EdocUR
repository.mail.fl_str_mv	edocur@urosario.edu.co
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A review of blood diseases and cytopenias associated with human parvovirus B19 infection

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