A review of blood diseases and cytopenias associated with human parvovirus B19 infection

Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages ha...

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Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22952
Acceso en línea:
https://doi.org/10.1002/rmv.1839
https://repository.urosario.edu.co/handle/10336/22952
Palabra clave:
Hemoglobin
Immunoglobulin g
Immunoglobulin m
Antigen antibody complex
Aplastic anemia
Arthralgia
Arthritis
Bone marrow
Bone marrow necrosis
Cell lineage
Chill
Cytopenia
Dna repair
Erythema infectiosum
Erythrophagocytosis
Granulocyte
Headache
Hematologic disease
Hemophagocytic syndrome
Human
Human parvovirus b19
Immunology
Lymphocyte
Macrophage
Megakaryocyte
Monocyte
Myalgia
Myelodysplastic syndrome
Myelophthisic anemia
Neutrophil
Nonhuman
Pathogenesis
Petechia
Pruritus
Rash
Reticulocyte
Review
Temperature
Thrombocyte
Thrombocytopenia
Virus excretion
Virus replication
Complication
Hematologic disease
Isolation and purification
Parvovirus infection
Virology
Hematologic diseases
Humans
Parvoviridae infections
human
Parvovirus b19
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License
Abierto (Texto Completo)
Description
Summary:Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describes the current state of knowledge of the abnormalities of individual blood cell lineages encountered during parvovirus B19 infection, over the almost 40years since its discovery, and reveals some very interesting themes, which improve our understanding of the pathogenesis of B19 infection with particular reference to the bone marrow. © 2015 John Wiley and Sons, Ltd.