Multiple sclerosis: Association to HLA DQ? in a tropical population

Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a p...

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Autores:
Tipo de recurso:
Fecha de publicación:
1999
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26619
Acceso en línea:
https://doi.org/10.1159/000019105
https://repository.urosario.edu.co/handle/10336/26619
Palabra clave:
Multiple sclerosis ethnology
Linkage disequilibrium
HLA-DQ Antigens genetic
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License
Restringido (Acceso a grupos específicos)
id EDOCUR2_5b086f55e070167f11bfcae7abcb20dc
oai_identifier_str oai:repository.urosario.edu.co:10336/26619
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling a626f35b-96bd-426e-8642-150b289e0ad7-10b6b53a9-0f80-4262-ab8a-301f616e4021-1871e26a7-c79b-4bd4-9de8-e42bf37a8e39-16b8224da-c9b3-4bdd-98bb-cfdd021fd597-130e3bb47-6dd9-4ebe-9e8b-31aae14e9a97-12020-08-19T14:39:54Z2020-08-19T14:39:54Z1999-06Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a possible association between MS and HLA DQ? (HLA DQA1*) alleles. Forty chromosomes belonging to MS patients were compared to two sets of controls (40 and 910 chromosomes, respectively). The HLA DQA1*0101 and DQA1*0102 alleles were found in a significantly higher proportion among the cases than among the controls, whereas the HLA DQA1*0103 allele was found in a significantly lower proportion of the cases. These results suggest that the association of HLA DQA1*0101, DQA1*0102 and DQA1*0103 to the MS phenotype found in Caucasian subtropical populations remains in individuals with MS inhabiting the tropics. This finding could mean that the major genetic component associated to the MHC in subtropical populations is the same in the tropics.application/pdfhttps://doi.org/10.1159/000019105ISSN: 0254-9670EISSN: 1421-9948https://repository.urosario.edu.co/handle/10336/26619engKarger AG138No. 3131Experimental and Clinical ImmunogeneticsVol. 16Experimental and Clinical Immunogenetics, ISSN: 0254-9670;EISSN: 1421-9948, Vol.16, No.3 (1999); pp. 131-138https://www.karger.com/Article/Abstract/19105Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecExperimental and Clinical Immunogeneticsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMultiple sclerosis ethnologyLinkage disequilibriumHLA-DQ Antigens geneticMultiple sclerosis: Association to HLA DQ? in a tropical populationEsclerosis múltiple: asociación con HLA DQ? en una población tropicalarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Arcos-Burgos, M.Palacio, GSánchez, J.LLondoño, A.C.Uribe, C.S.10336/26619oai:repository.urosario.edu.co:10336/266192021-06-03 00:49:55.851https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Multiple sclerosis: Association to HLA DQ? in a tropical population
dc.title.TranslatedTitle.spa.fl_str_mv Esclerosis múltiple: asociación con HLA DQ? en una población tropical
title Multiple sclerosis: Association to HLA DQ? in a tropical population
spellingShingle Multiple sclerosis: Association to HLA DQ? in a tropical population
Multiple sclerosis ethnology
Linkage disequilibrium
HLA-DQ Antigens genetic
title_short Multiple sclerosis: Association to HLA DQ? in a tropical population
title_full Multiple sclerosis: Association to HLA DQ? in a tropical population
title_fullStr Multiple sclerosis: Association to HLA DQ? in a tropical population
title_full_unstemmed Multiple sclerosis: Association to HLA DQ? in a tropical population
title_sort Multiple sclerosis: Association to HLA DQ? in a tropical population
dc.subject.keyword.spa.fl_str_mv Multiple sclerosis ethnology
Linkage disequilibrium
HLA-DQ Antigens genetic
topic Multiple sclerosis ethnology
Linkage disequilibrium
HLA-DQ Antigens genetic
description Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a possible association between MS and HLA DQ? (HLA DQA1*) alleles. Forty chromosomes belonging to MS patients were compared to two sets of controls (40 and 910 chromosomes, respectively). The HLA DQA1*0101 and DQA1*0102 alleles were found in a significantly higher proportion among the cases than among the controls, whereas the HLA DQA1*0103 allele was found in a significantly lower proportion of the cases. These results suggest that the association of HLA DQA1*0101, DQA1*0102 and DQA1*0103 to the MS phenotype found in Caucasian subtropical populations remains in individuals with MS inhabiting the tropics. This finding could mean that the major genetic component associated to the MHC in subtropical populations is the same in the tropics.
publishDate 1999
dc.date.created.spa.fl_str_mv 1999-06
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:39:54Z
dc.date.available.none.fl_str_mv 2020-08-19T14:39:54Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1159/000019105
dc.identifier.issn.none.fl_str_mv ISSN: 0254-9670
EISSN: 1421-9948
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26619
url https://doi.org/10.1159/000019105
https://repository.urosario.edu.co/handle/10336/26619
identifier_str_mv ISSN: 0254-9670
EISSN: 1421-9948
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 138
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 131
dc.relation.citationTitle.none.fl_str_mv Experimental and Clinical Immunogenetics
dc.relation.citationVolume.none.fl_str_mv Vol. 16
dc.relation.ispartof.spa.fl_str_mv Experimental and Clinical Immunogenetics, ISSN: 0254-9670;EISSN: 1421-9948, Vol.16, No.3 (1999); pp. 131-138
dc.relation.uri.spa.fl_str_mv https://www.karger.com/Article/Abstract/19105
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Karger AG
dc.source.spa.fl_str_mv Experimental and Clinical Immunogenetics
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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