Multiple sclerosis: Association to HLA DQ? in a tropical population
Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a p...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 1999
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26619
- Acceso en línea:
- https://doi.org/10.1159/000019105
https://repository.urosario.edu.co/handle/10336/26619
- Palabra clave:
- Multiple sclerosis ethnology
Linkage disequilibrium
HLA-DQ Antigens genetic
- Rights
- License
- Restringido (Acceso a grupos específicos)
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EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
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a626f35b-96bd-426e-8642-150b289e0ad7-10b6b53a9-0f80-4262-ab8a-301f616e4021-1871e26a7-c79b-4bd4-9de8-e42bf37a8e39-16b8224da-c9b3-4bdd-98bb-cfdd021fd597-130e3bb47-6dd9-4ebe-9e8b-31aae14e9a97-12020-08-19T14:39:54Z2020-08-19T14:39:54Z1999-06Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a possible association between MS and HLA DQ? (HLA DQA1*) alleles. Forty chromosomes belonging to MS patients were compared to two sets of controls (40 and 910 chromosomes, respectively). The HLA DQA1*0101 and DQA1*0102 alleles were found in a significantly higher proportion among the cases than among the controls, whereas the HLA DQA1*0103 allele was found in a significantly lower proportion of the cases. These results suggest that the association of HLA DQA1*0101, DQA1*0102 and DQA1*0103 to the MS phenotype found in Caucasian subtropical populations remains in individuals with MS inhabiting the tropics. This finding could mean that the major genetic component associated to the MHC in subtropical populations is the same in the tropics.application/pdfhttps://doi.org/10.1159/000019105ISSN: 0254-9670EISSN: 1421-9948https://repository.urosario.edu.co/handle/10336/26619engKarger AG138No. 3131Experimental and Clinical ImmunogeneticsVol. 16Experimental and Clinical Immunogenetics, ISSN: 0254-9670;EISSN: 1421-9948, Vol.16, No.3 (1999); pp. 131-138https://www.karger.com/Article/Abstract/19105Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecExperimental and Clinical Immunogeneticsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMultiple sclerosis ethnologyLinkage disequilibriumHLA-DQ Antigens geneticMultiple sclerosis: Association to HLA DQ? in a tropical populationEsclerosis múltiple: asociación con HLA DQ? en una población tropicalarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Arcos-Burgos, M.Palacio, GSánchez, J.LLondoño, A.C.Uribe, C.S.10336/26619oai:repository.urosario.edu.co:10336/266192021-06-03 00:49:55.851https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
dc.title.TranslatedTitle.spa.fl_str_mv |
Esclerosis múltiple: asociación con HLA DQ? en una población tropical |
title |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
spellingShingle |
Multiple sclerosis: Association to HLA DQ? in a tropical population Multiple sclerosis ethnology Linkage disequilibrium HLA-DQ Antigens genetic |
title_short |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
title_full |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
title_fullStr |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
title_full_unstemmed |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
title_sort |
Multiple sclerosis: Association to HLA DQ? in a tropical population |
dc.subject.keyword.spa.fl_str_mv |
Multiple sclerosis ethnology Linkage disequilibrium HLA-DQ Antigens genetic |
topic |
Multiple sclerosis ethnology Linkage disequilibrium HLA-DQ Antigens genetic |
description |
Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a possible association between MS and HLA DQ? (HLA DQA1*) alleles. Forty chromosomes belonging to MS patients were compared to two sets of controls (40 and 910 chromosomes, respectively). The HLA DQA1*0101 and DQA1*0102 alleles were found in a significantly higher proportion among the cases than among the controls, whereas the HLA DQA1*0103 allele was found in a significantly lower proportion of the cases. These results suggest that the association of HLA DQA1*0101, DQA1*0102 and DQA1*0103 to the MS phenotype found in Caucasian subtropical populations remains in individuals with MS inhabiting the tropics. This finding could mean that the major genetic component associated to the MHC in subtropical populations is the same in the tropics. |
publishDate |
1999 |
dc.date.created.spa.fl_str_mv |
1999-06 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:39:54Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:39:54Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1159/000019105 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0254-9670 EISSN: 1421-9948 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26619 |
url |
https://doi.org/10.1159/000019105 https://repository.urosario.edu.co/handle/10336/26619 |
identifier_str_mv |
ISSN: 0254-9670 EISSN: 1421-9948 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
138 |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationStartPage.none.fl_str_mv |
131 |
dc.relation.citationTitle.none.fl_str_mv |
Experimental and Clinical Immunogenetics |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 16 |
dc.relation.ispartof.spa.fl_str_mv |
Experimental and Clinical Immunogenetics, ISSN: 0254-9670;EISSN: 1421-9948, Vol.16, No.3 (1999); pp. 131-138 |
dc.relation.uri.spa.fl_str_mv |
https://www.karger.com/Article/Abstract/19105 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Karger AG |
dc.source.spa.fl_str_mv |
Experimental and Clinical Immunogenetics |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167720792424448 |