Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease

Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: V...

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Fecha de publicación:: 2018

Institución:: Universidad del Rosario

Repositorio:: Repositorio EdocUR - U. Rosario

Idioma:: eng

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spelling	075cd1f5-fe86-43f9-a84c-1c1bc5c10bd85170135560075481961-d9f8-49a2-9cbb-91c08a431bd92020-05-25T23:57:40Z2020-05-25T23:57:40Z2018Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop. ©, © Taylor and Francis Group, LLC.application/pdfhttps://doi.org/10.1080/09273948.2017.13204119273948https://repository.urosario.edu.co/handle/10336/22717engTaylor and Francis Ltd1106No. 71101Ocular Immunology and InflammationVol. 26Ocular Immunology and Inflammation, ISSN:9273948, Vol.26, No.7 (2018); pp. 1101-1106https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019707641&doi=10.1080%2f09273948.2017.1320411&partnerID=40&md5=006a9f59c57db046fdb6b370caf7af91Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCyclosporineDexamethasoneFolic acidMethotrexatePrednisoneAdultAgedAnterior eye chamberAntiangiogenic activityArmArticleB scanBest corrected visual acuityBilateral iris depigmentationBiomicroscopyCase reportCataractCataract extractionCiliary bodyClinical articleClinical featureClinical outcomeConsultationCorneaDepigmentationDiagnostic testDisease durationDisease severityDrug dose escalationEarly diagnosisEye examinationEye fundusEyelidFemaleGranulomatosisHandHealth serviceHospital admissionHumanImmunosuppressive treatmentIntraocular hypertensionIntraocular hypotensionIntraocular pressureIris atrophyIris diseaseLens implantationMacular edemaMaleMedical historyMiddle agedMultiple cycle treatmentNeckOptical coherence tomographyPatient referralPterygiumRecurrent diseaseRetina detachmentRetina fluorescein angiographyRetina macula cystoid edemaSlit lamp microscopyTransilluminationTreatment indicationUveitisVisual acuityVitiligoVitrectomyVitreous opacityVogt koyanagi syndromeAtrophyHypopigmentationIntraocular hypotensionIrisIris diseaseMeningoencephalitisPathologyPigment epitheliumSlit lampAdultAgedAtrophyFemaleHumansHypopigmentationIrisIris diseasesMaleMiddle agedOcular hypotensionPigment epithelium of eyeSlit lampUveomeningoencephalitic syndromeIris atrophyIris depigmentationOcular hypotonyPanuveitisVkhVogt–koyanagi–harada diseaseoptical coherenceTomographyBilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada DiseasearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cuevas M.de-la-Torre, AlejandraCórdoba A.10336/22717oai:repository.urosario.edu.co:10336/227172022-05-02 07:37:15.943908https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
title	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
spellingShingle	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease Cyclosporine Dexamethasone Folic acid Methotrexate Prednisone Adult Aged Anterior eye chamber Antiangiogenic activity Arm Article B scan Best corrected visual acuity Bilateral iris depigmentation Biomicroscopy Case report Cataract Cataract extraction Ciliary body Clinical article Clinical feature Clinical outcome Consultation Cornea Depigmentation Diagnostic test Disease duration Disease severity Drug dose escalation Early diagnosis Eye examination Eye fundus Eyelid Female Granulomatosis Hand Health service Hospital admission Human Immunosuppressive treatment Intraocular hypertension Intraocular hypotension Intraocular pressure Iris atrophy Iris disease Lens implantation Macular edema Male Medical history Middle aged Multiple cycle treatment Neck Optical coherence tomography Patient referral Pterygium Recurrent disease Retina detachment Retina fluorescein angiography Retina macula cystoid edema Slit lamp microscopy Transillumination Treatment indication Uveitis Visual acuity Vitiligo Vitrectomy Vitreous opacity Vogt koyanagi syndrome Atrophy Hypopigmentation Intraocular hypotension Iris Iris disease Meningoencephalitis Pathology Pigment epithelium Slit lamp Adult Aged Atrophy Female Humans Hypopigmentation Iris Iris diseases Male Middle aged Ocular hypotension Pigment epithelium of eye Slit lamp Uveomeningoencephalitic syndrome Iris atrophy Iris depigmentation Ocular hypotony Panuveitis Vkh Vogt–koyanagi–harada disease optical coherence Tomography
title_short	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
title_full	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
title_fullStr	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
title_full_unstemmed	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
title_sort	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease
dc.subject.keyword.spa.fl_str_mv	Cyclosporine Dexamethasone Folic acid Methotrexate Prednisone Adult Aged Anterior eye chamber Antiangiogenic activity Arm Article B scan Best corrected visual acuity Bilateral iris depigmentation Biomicroscopy Case report Cataract Cataract extraction Ciliary body Clinical article Clinical feature Clinical outcome Consultation Cornea Depigmentation Diagnostic test Disease duration Disease severity Drug dose escalation Early diagnosis Eye examination Eye fundus Eyelid Female Granulomatosis Hand Health service Hospital admission Human Immunosuppressive treatment Intraocular hypertension Intraocular hypotension Intraocular pressure Iris atrophy Iris disease Lens implantation Macular edema Male Medical history Middle aged Multiple cycle treatment Neck Optical coherence tomography Patient referral Pterygium Recurrent disease Retina detachment Retina fluorescein angiography Retina macula cystoid edema Slit lamp microscopy Transillumination Treatment indication Uveitis Visual acuity Vitiligo Vitrectomy Vitreous opacity Vogt koyanagi syndrome Atrophy Hypopigmentation Intraocular hypotension Iris Iris disease Meningoencephalitis Pathology Pigment epithelium Slit lamp Adult Aged Atrophy Female Humans Hypopigmentation Iris Iris diseases Male Middle aged Ocular hypotension Pigment epithelium of eye Slit lamp Uveomeningoencephalitic syndrome Iris atrophy Iris depigmentation Ocular hypotony Panuveitis Vkh Vogt–koyanagi–harada disease
topic	Cyclosporine Dexamethasone Folic acid Methotrexate Prednisone Adult Aged Anterior eye chamber Antiangiogenic activity Arm Article B scan Best corrected visual acuity Bilateral iris depigmentation Biomicroscopy Case report Cataract Cataract extraction Ciliary body Clinical article Clinical feature Clinical outcome Consultation Cornea Depigmentation Diagnostic test Disease duration Disease severity Drug dose escalation Early diagnosis Eye examination Eye fundus Eyelid Female Granulomatosis Hand Health service Hospital admission Human Immunosuppressive treatment Intraocular hypertension Intraocular hypotension Intraocular pressure Iris atrophy Iris disease Lens implantation Macular edema Male Medical history Middle aged Multiple cycle treatment Neck Optical coherence tomography Patient referral Pterygium Recurrent disease Retina detachment Retina fluorescein angiography Retina macula cystoid edema Slit lamp microscopy Transillumination Treatment indication Uveitis Visual acuity Vitiligo Vitrectomy Vitreous opacity Vogt koyanagi syndrome Atrophy Hypopigmentation Intraocular hypotension Iris Iris disease Meningoencephalitis Pathology Pigment epithelium Slit lamp Adult Aged Atrophy Female Humans Hypopigmentation Iris Iris diseases Male Middle aged Ocular hypotension Pigment epithelium of eye Slit lamp Uveomeningoencephalitic syndrome Iris atrophy Iris depigmentation Ocular hypotony Panuveitis Vkh Vogt–koyanagi–harada disease optical coherence Tomography
dc.subject.keyword.eng.fl_str_mv	optical coherence Tomography
description	Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop. ©, © Taylor and Francis Group, LLC.
publishDate	2018
dc.date.created.spa.fl_str_mv	2018
dc.date.accessioned.none.fl_str_mv	2020-05-25T23:57:40Z
dc.date.available.none.fl_str_mv	2020-05-25T23:57:40Z
dc.type.eng.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv	Artículo
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1080/09273948.2017.1320411
dc.identifier.issn.none.fl_str_mv	9273948
dc.identifier.uri.none.fl_str_mv	https://repository.urosario.edu.co/handle/10336/22717
url	https://doi.org/10.1080/09273948.2017.1320411 https://repository.urosario.edu.co/handle/10336/22717
identifier_str_mv	9273948
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.relation.citationEndPage.none.fl_str_mv	1106
dc.relation.citationIssue.none.fl_str_mv	No. 7
dc.relation.citationStartPage.none.fl_str_mv	1101
dc.relation.citationTitle.none.fl_str_mv	Ocular Immunology and Inflammation
dc.relation.citationVolume.none.fl_str_mv	Vol. 26
dc.relation.ispartof.spa.fl_str_mv	Ocular Immunology and Inflammation, ISSN:9273948, Vol.26, No.7 (2018); pp. 1101-1106
dc.relation.uri.spa.fl_str_mv	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019707641&doi=10.1080%2f09273948.2017.1320411&partnerID=40&md5=006a9f59c57db046fdb6b370caf7af91
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv	Abierto (Texto Completo)
rights_invalid_str_mv	Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Taylor and Francis Ltd
institution	Universidad del Rosario
dc.source.instname.spa.fl_str_mv	instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv	reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv	Repositorio institucional EdocUR
repository.mail.fl_str_mv	edocur@urosario.edu.co
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Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt–Koyanagi–Harada Disease

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