Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)

INTRODUCTION: Bile fluid is aseptic under normal conditions

Autores:

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad del Rosario

Repositorio:: Repositorio EdocUR - U. Rosario

Idioma:: eng

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dc.title.spa.fl_str_mv	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
title	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
spellingShingle	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO) Adult surgery Hepatobiliary surgery Microbiology
title_short	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
title_full	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
title_fullStr	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
title_full_unstemmed	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
title_sort	Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)
dc.subject.spa.fl_str_mv	Adult surgery Hepatobiliary surgery Microbiology
topic	Adult surgery Hepatobiliary surgery Microbiology
description	INTRODUCTION: Bile fluid is aseptic under normal conditions
publishDate	2024
dc.date.created.spa.fl_str_mv	2024-11-01
dc.date.issued.spa.fl_str_mv	2024-11-01
dc.date.accessioned.none.fl_str_mv	2025-01-26T18:34:03Z
dc.date.available.none.fl_str_mv	2025-01-26T18:34:03Z
dc.type.spa.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv	Artículo
dc.identifier.doi.spa.fl_str_mv	https://doi.org/10.1136/bmjopen-2024-086655
dc.identifier.uri.none.fl_str_mv	https://repository.urosario.edu.co/handle/10336/44831
url	https://doi.org/10.1136/bmjopen-2024-086655 https://repository.urosario.edu.co/handle/10336/44831
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.relation.ispartof.spa.fl_str_mv	BMJ Open
dc.rights.spa.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv	Abierto (Texto Completo)
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-sa/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International Abierto (Texto Completo) http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	BMJ Open
dc.source.spa.fl_str_mv	BMJ Open
institution	Universidad del Rosario
dc.source.instname.spa.fl_str_mv	instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv	reponame:Repositorio Institucional EdocUR
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio institucional EdocUR
repository.mail.fl_str_mv	edocur@urosario.edu.co
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spelling	4ba1b070-a9dd-47d0-b94d-5cfea228150d563c8b5e-07f0-4108-b13c-ac4c6d0cf1ef32298566008bb7e42b-d36c-4d2c-bde2-8b88c9107cbcca099423-59ea-4a9a-8a36-2174c53bd2d6b61abc6b-284c-4829-be5b-a73a2f0ae89a2025-01-26T18:34:03Z2025-01-26T18:34:03Z2024-11-012024-11-01INTRODUCTION: Bile fluid is aseptic under normal conditionshowever, in the presence of cholecystitis, its susceptibility to bacterial colonisation varies, with reported rates of 20%-70% of cases. This process is referred to as bactibilia and/or bacteriobilia and can be considered a secondary complication of biliary stasis and cholecystitis in general. In the management of acute cholecystitis, the antibiotic regimen should be prescribed based on the presumed pathogens involved, taking into consideration the risk factors for resistance patterns according to demographics and local exposure. The aim of this study is to determine the predictive factors for bile culture positivity and antibiotic resistance in patients who underwent laparoscopic cholecystectomy in the Méderi Hospital Network. We hope to develop a predictive model that allows us to better guide antibiotic therapy. METHODS AND ANALYSIS: This is a prospective observational cohort study with prognostic prediction model. Patients who will undergo laparoscopic cholecystectomy and have bile cultures taken in the Méderi Hospital Network during the study period will be included. The dependent variables will be positive bile culture and antibiotic resistance, and the predictive variables will be age, presence of diabetes, diagnosis of choledocholithiasis, diagnosis of cholecystitis and severity of cholecystitis according to the Tokyo criteria. The minimum sample size has been calculated at 703 patients. Follow-up will continue until a control appointment 15 days after the procedure. The primary outcomes are bile culture positivity and phenotypical antibiogram resistance. For each outcome, a multivariate logistic regression will be performed using frequentist and Bayesian prediction techniques. ETHICS AND DISSEMINATION: This study was approved by the Méderi network research department committee (CIMED) and by Universidad del Rosario's Research Ethics Committee (CEI-URDVO005 2555-CV1837). Written informed consent is required for participation. The results will be disseminated through the submission of an academic article to a high-impact scientific journal, presentations at academic conferences, and sharing with our institution's faculty to inform antimicrobial therapy management based on local epidemiological data. TRIAL REGISTRATION NUMBER: NCT06314399.application/pdfhttps://doi.org/10.1136/bmjopen-2024-086655https://repository.urosario.edu.co/handle/10336/44831engBMJ OpenBMJ OpenAttribution-NonCommercial-NoDerivatives 4.0 InternationalAbierto (Texto Completo)http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2BMJ Openinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAdult surgeryHepatobiliary surgeryMicrobiologyPredictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ramírez-Giraldo,CamiloRodríguez Barbosa, CarlosIsaza Restrepo, AndrésAvendaño-Morales, VioletaRojas-López, SusanaVan-Londoño, IsabellaORIGINALPredictive_factors_associated_with_Bile_culture_positivity_And_phenotypiCal.pdfapplication/pdf254568https://repository.urosario.edu.co/bitstreams/cb36f30f-cadd-4509-973d-3c763eb18ec3/download80b590ce6ddc6db1291eba3f3788a893MD51TEXTPredictive_factors_associated_with_Bile_culture_positivity_And_phenotypiCal.pdf.txtPredictive_factors_associated_with_Bile_culture_positivity_And_phenotypiCal.pdf.txtExtracted texttext/plain41453https://repository.urosario.edu.co/bitstreams/ea3905f2-1190-4aed-bab8-90d150b23551/download851069c044c379558ad62110ac81f8d5MD52THUMBNAILPredictive_factors_associated_with_Bile_culture_positivity_And_phenotypiCal.pdf.jpgPredictive_factors_associated_with_Bile_culture_positivity_And_phenotypiCal.pdf.jpgGenerated Thumbnailimage/jpeg5328https://repository.urosario.edu.co/bitstreams/9d6e5481-1e23-45b6-b597-873f0b7128f9/downloadbb1d3437d74b9f18da31e0cad74c2871MD5310336/44831oai:repository.urosario.edu.co:10336/448312025-03-05 09:05:07.434http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co

Predictive factors associated with Bile culture positivity And phenotypiCal antIbiogram resistance patterns in patients taken to LaparOscopic cholecystectomy (BACILO)

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