Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
Trypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable geneti...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/21640
- Acceso en línea:
- https://doi.org/10.1590/0074-02760140402
https://repository.urosario.edu.co/handle/10336/21640
- Palabra clave:
- Enfermedad de Chagas
Genotipos
Ciclo doméstico
Ciclo selvático
Enfermedades
Chagas disease
Genotypes
Domestica cycle
Sylvatic cycle
Trypanosoma cruzi
Enfermedad de chagas
- Rights
- License
- Abierto (Texto Completo)
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9e515a17-bef3-4b2e-91b8-1e711719314d600520857956003f09886f-3c2c-4bf8-8cb6-88a92b59853a60010117161186002020-04-15T21:55:58Z2020-04-15T21:55:58Z20152015Trypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable genetic diversity; a genotype linked to human infections and a domestic cycle of transmission have recently been identified, hence, this strain was named TcIDom. The aim of this work was to describe the spatiotemporal distribution of TcI subpopulations across humans, insect vectors and mammalian reservoirs in Colombia by means of molecular typing targeting the spliced leader intergenic region of mini-exon gene. We analysed 101 TcI isolates and observed a distribution of sylvatic TcI in 70% and TcIDom in 30%. In humans, the ratio was sylvatic TcI in 60% and TcIDom in 40%. In mammal reservoirs, the distribution corresponded to sylvatic TcI in 96% and TcIDom in 4%. Among insect vectors, sylvatic TcI was observed in 48% and TcIDom in 52%. In conclusion, the circulation of TcIDom is emerging in Colombia and this genotype is still adapting to the domestic cycle of transmission. The epidemiological and clinical implications of these findings are discussed herein. © 2015, Fundacao Oswaldo Cruz. All rights reserved.application/pdfhttps://doi.org/10.1590/0074-027601404020074-0276https://repository.urosario.edu.co/handle/10336/21640eng393No. 3387Memorias do Instituto Oswaldo CruzVol. 110Memorias do Instituto Oswaldo Cruz, ISSN: 0074-0276 Vol. 110, No. 3 (2015) pp. 387-393http://www.scielo.br/pdf/mioc/v110n3/0074-0276-mioc-0074-02760140402.pdfAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedad de ChagasGenotiposCiclo domésticoCiclo selváticoEnfermedades616600Chagas diseaseGenotypesDomestica cycleSylvatic cycleTrypanosoma cruziEnfermedad de chagasRetrospective distribution of Trypanosoma cruzi I genotypes in ColombiaarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501León, Cielo M.Hernández, CarolinaMontilla, MarlenyRamírez, Juan DavidLeón, Cielo MHernández, CarolinaMontilla, MarlenyRamírez, Juan DavidORIGINALRetrospective_distribution_of_Trypanosoma_cruzi_I_genotypes_in_Colombia.pdfapplication/pdf773055https://repository.urosario.edu.co/bitstreams/cb93886d-782d-4393-afda-a00cf1cb850a/download9e4cdbcd64a39cb691c10284088e192bMD51TEXTRetrospective_distribution_of_Trypanosoma_cruzi_I_genotypes_in_Colombia.pdf.txtRetrospective_distribution_of_Trypanosoma_cruzi_I_genotypes_in_Colombia.pdf.txtExtracted texttext/plain33770https://repository.urosario.edu.co/bitstreams/6d3b96d6-e174-436b-a288-c74e42fcce0e/downloadbca862ab9f9577e3509e300d78114b19MD52THUMBNAILRetrospective_distribution_of_Trypanosoma_cruzi_I_genotypes_in_Colombia.pdf.jpgRetrospective_distribution_of_Trypanosoma_cruzi_I_genotypes_in_Colombia.pdf.jpgGenerated Thumbnailimage/jpeg4662https://repository.urosario.edu.co/bitstreams/363a5017-9a06-42d5-9d8d-6270215ed0bf/download07069a3be12c55e8bed867c5c18fa468MD5310336/21640oai:repository.urosario.edu.co:10336/216402020-05-13 14:48:07.632https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
title |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
spellingShingle |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia Enfermedad de Chagas Genotipos Ciclo doméstico Ciclo selvático Enfermedades Chagas disease Genotypes Domestica cycle Sylvatic cycle Trypanosoma cruzi Enfermedad de chagas |
title_short |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
title_full |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
title_fullStr |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
title_full_unstemmed |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
title_sort |
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia |
dc.subject.spa.fl_str_mv |
Enfermedad de Chagas Genotipos Ciclo doméstico Ciclo selvático |
topic |
Enfermedad de Chagas Genotipos Ciclo doméstico Ciclo selvático Enfermedades Chagas disease Genotypes Domestica cycle Sylvatic cycle Trypanosoma cruzi Enfermedad de chagas |
dc.subject.ddc.spa.fl_str_mv |
Enfermedades |
dc.subject.keyword.spa.fl_str_mv |
Chagas disease Genotypes Domestica cycle Sylvatic cycle |
dc.subject.lemb.spa.fl_str_mv |
Trypanosoma cruzi Enfermedad de chagas |
description |
Trypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable genetic diversity; a genotype linked to human infections and a domestic cycle of transmission have recently been identified, hence, this strain was named TcIDom. The aim of this work was to describe the spatiotemporal distribution of TcI subpopulations across humans, insect vectors and mammalian reservoirs in Colombia by means of molecular typing targeting the spliced leader intergenic region of mini-exon gene. We analysed 101 TcI isolates and observed a distribution of sylvatic TcI in 70% and TcIDom in 30%. In humans, the ratio was sylvatic TcI in 60% and TcIDom in 40%. In mammal reservoirs, the distribution corresponded to sylvatic TcI in 96% and TcIDom in 4%. Among insect vectors, sylvatic TcI was observed in 48% and TcIDom in 52%. In conclusion, the circulation of TcIDom is emerging in Colombia and this genotype is still adapting to the domestic cycle of transmission. The epidemiological and clinical implications of these findings are discussed herein. © 2015, Fundacao Oswaldo Cruz. All rights reserved. |
publishDate |
2015 |
dc.date.created.none.fl_str_mv |
2015 |
dc.date.issued.none.fl_str_mv |
2015 |
dc.date.accessioned.none.fl_str_mv |
2020-04-15T21:55:58Z |
dc.date.available.none.fl_str_mv |
2020-04-15T21:55:58Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1590/0074-02760140402 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/21640 |
url |
https://doi.org/10.1590/0074-02760140402 https://repository.urosario.edu.co/handle/10336/21640 |
identifier_str_mv |
0074-0276 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
393 |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationStartPage.none.fl_str_mv |
387 |
dc.relation.citationTitle.none.fl_str_mv |
Memorias do Instituto Oswaldo Cruz |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 110 |
dc.relation.ispartof.spa.fl_str_mv |
Memorias do Instituto Oswaldo Cruz, ISSN: 0074-0276 Vol. 110, No. 3 (2015) pp. 387-393 |
dc.relation.uri.spa.fl_str_mv |
http://www.scielo.br/pdf/mioc/v110n3/0074-0276-mioc-0074-02760140402.pdf |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
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Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Universidad del Rosario |
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