Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia

Trypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable geneti...

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Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/21640
Acceso en línea:
https://doi.org/10.1590/0074-02760140402
https://repository.urosario.edu.co/handle/10336/21640
Palabra clave:
Enfermedad de Chagas
Genotipos
Ciclo doméstico
Ciclo selvático
Enfermedades
Chagas disease
Genotypes
Domestica cycle
Sylvatic cycle
Trypanosoma cruzi
Enfermedad de chagas
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
title Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
spellingShingle Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
Enfermedad de Chagas
Genotipos
Ciclo doméstico
Ciclo selvático
Enfermedades
Chagas disease
Genotypes
Domestica cycle
Sylvatic cycle
Trypanosoma cruzi
Enfermedad de chagas
title_short Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
title_full Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
title_fullStr Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
title_full_unstemmed Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
title_sort Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia
dc.subject.spa.fl_str_mv Enfermedad de Chagas
Genotipos
Ciclo doméstico
Ciclo selvático
topic Enfermedad de Chagas
Genotipos
Ciclo doméstico
Ciclo selvático
Enfermedades
Chagas disease
Genotypes
Domestica cycle
Sylvatic cycle
Trypanosoma cruzi
Enfermedad de chagas
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.keyword.spa.fl_str_mv Chagas disease
Genotypes
Domestica cycle
Sylvatic cycle
dc.subject.lemb.spa.fl_str_mv Trypanosoma cruzi
Enfermedad de chagas
description Trypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable genetic diversity; a genotype linked to human infections and a domestic cycle of transmission have recently been identified, hence, this strain was named TcIDom. The aim of this work was to describe the spatiotemporal distribution of TcI subpopulations across humans, insect vectors and mammalian reservoirs in Colombia by means of molecular typing targeting the spliced leader intergenic region of mini-exon gene. We analysed 101 TcI isolates and observed a distribution of sylvatic TcI in 70% and TcIDom in 30%. In humans, the ratio was sylvatic TcI in 60% and TcIDom in 40%. In mammal reservoirs, the distribution corresponded to sylvatic TcI in 96% and TcIDom in 4%. Among insect vectors, sylvatic TcI was observed in 48% and TcIDom in 52%. In conclusion, the circulation of TcIDom is emerging in Colombia and this genotype is still adapting to the domestic cycle of transmission. The epidemiological and clinical implications of these findings are discussed herein. © 2015, Fundacao Oswaldo Cruz. All rights reserved.
publishDate 2015
dc.date.created.none.fl_str_mv 2015
dc.date.issued.none.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2020-04-15T21:55:58Z
dc.date.available.none.fl_str_mv 2020-04-15T21:55:58Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/0074-02760140402
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/21640
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https://repository.urosario.edu.co/handle/10336/21640
identifier_str_mv 0074-0276
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 393
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 387
dc.relation.citationTitle.none.fl_str_mv Memorias do Instituto Oswaldo Cruz
dc.relation.citationVolume.none.fl_str_mv Vol. 110
dc.relation.ispartof.spa.fl_str_mv Memorias do Instituto Oswaldo Cruz, ISSN: 0074-0276 Vol. 110, No. 3 (2015) pp. 387-393
dc.relation.uri.spa.fl_str_mv http://www.scielo.br/pdf/mioc/v110n3/0074-0276-mioc-0074-02760140402.pdf
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dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
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institution Universidad del Rosario
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