Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

Systemic lupus erythematosus (SLE) is considered to be the prototypic autoimmune disease, with a complex genetic architecture influenced by environmental factors. We sought to replicate a putative association at 11p13 not yet exceeding genome-wide significance (p < 5 × 10-8) identified in a g...

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Tipo de recurso:
Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/18752
Acceso en línea:
http://repository.urosario.edu.co/handle/10336/18752
Palabra clave:
Cd44V Antigen
Cd44
Single Nucleotide
Human
Pyruvate Dehydrogenase Complex
Pair 11
African American
American Indian
Asian
Caucasian
Chromosome 11P
Cohort Analysis
Controlled Study
Gene Locus
Genetic Association
Genetic Susceptibility
Hispanic
Human
Major Clinical Study
Male
Meta Analysis
Priority Journal
Single Nucleotide Polymorphism
Statistical Analysis
Systemic Lupus Erythematosus
African Americans
American Native Continental Ancestry Group
Antigens
Asian Continental Ancestry Group
Chromosomes
Cohort Studies
European Continental Ancestry Group
Genetic Loci
Genetic Predisposition To Disease
Haplotypes
Hispanic Americans
Linkage Disequilibrium
Male
Polymorphism
Pyruvate Dehydrogenase Complex
Systemic
Lupus Erythematosus
Article
Female
Female
Humans
Lupus Eritomatoso Sistémico
Enfermedades autoinmunes
Enfermedades de la piel
Rights
License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
title Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
spellingShingle Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
Cd44V Antigen
Cd44
Single Nucleotide
Human
Pyruvate Dehydrogenase Complex
Pair 11
African American
American Indian
Asian
Caucasian
Chromosome 11P
Cohort Analysis
Controlled Study
Gene Locus
Genetic Association
Genetic Susceptibility
Hispanic
Human
Major Clinical Study
Male
Meta Analysis
Priority Journal
Single Nucleotide Polymorphism
Statistical Analysis
Systemic Lupus Erythematosus
African Americans
American Native Continental Ancestry Group
Antigens
Asian Continental Ancestry Group
Chromosomes
Cohort Studies
European Continental Ancestry Group
Genetic Loci
Genetic Predisposition To Disease
Haplotypes
Hispanic Americans
Linkage Disequilibrium
Male
Polymorphism
Pyruvate Dehydrogenase Complex
Systemic
Lupus Erythematosus
Article
Female
Female
Humans
Lupus Eritomatoso Sistémico
Enfermedades autoinmunes
Enfermedades de la piel
title_short Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
title_full Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
title_fullStr Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
title_full_unstemmed Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
title_sort Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
dc.subject.spa.fl_str_mv Cd44V Antigen
Cd44
Single Nucleotide
Human
Pyruvate Dehydrogenase Complex
Pair 11
African American
American Indian
Asian
Caucasian
Chromosome 11P
Cohort Analysis
Controlled Study
Gene Locus
Genetic Association
Genetic Susceptibility
Hispanic
Human
Major Clinical Study
Male
Meta Analysis
Priority Journal
Single Nucleotide Polymorphism
Statistical Analysis
Systemic Lupus Erythematosus
African Americans
American Native Continental Ancestry Group
Antigens
Asian Continental Ancestry Group
Chromosomes
Cohort Studies
European Continental Ancestry Group
Genetic Loci
Genetic Predisposition To Disease
Haplotypes
Hispanic Americans
Linkage Disequilibrium
Male
Polymorphism
Pyruvate Dehydrogenase Complex
topic Cd44V Antigen
Cd44
Single Nucleotide
Human
Pyruvate Dehydrogenase Complex
Pair 11
African American
American Indian
Asian
Caucasian
Chromosome 11P
Cohort Analysis
Controlled Study
Gene Locus
Genetic Association
Genetic Susceptibility
Hispanic
Human
Major Clinical Study
Male
Meta Analysis
Priority Journal
Single Nucleotide Polymorphism
Statistical Analysis
Systemic Lupus Erythematosus
African Americans
American Native Continental Ancestry Group
Antigens
Asian Continental Ancestry Group
Chromosomes
Cohort Studies
European Continental Ancestry Group
Genetic Loci
Genetic Predisposition To Disease
Haplotypes
Hispanic Americans
Linkage Disequilibrium
Male
Polymorphism
Pyruvate Dehydrogenase Complex
Systemic
Lupus Erythematosus
Article
Female
Female
Humans
Lupus Eritomatoso Sistémico
Enfermedades autoinmunes
Enfermedades de la piel
dc.subject.keyword.eng.fl_str_mv Systemic
Lupus Erythematosus
dc.subject.keyword.spa.fl_str_mv Article
Female
Female
Humans
dc.subject.lemb.spa.fl_str_mv Lupus Eritomatoso Sistémico
Enfermedades autoinmunes
Enfermedades de la piel
description Systemic lupus erythematosus (SLE) is considered to be the prototypic autoimmune disease, with a complex genetic architecture influenced by environmental factors. We sought to replicate a putative association at 11p13 not yet exceeding genome-wide significance (p < 5 × 10-8) identified in a genome-wide association study (GWAS). Our GWA scan identified two intergenic SNPs located between PDHX and CD44 showing suggestive evidence of association with SLE in cases of European descent (rs2732552, p = 0.004, odds ratio [OR] = 0.78; rs387619, p = 0.003, OR = 0.78). The replication cohort consisted of >15,000 subjects, including 3562 SLE cases and 3491 controls of European ancestry, 1527 cases and 1811 controls of African American (AA) descent, and 1265 cases and 1260 controls of Asian origin. We observed robust association at both rs2732552 (p = 9.03 × 10-8, OR = 0.83) and rs387619 (p = 7.7 × 10-7, OR = 0.83) in the European samples with pmeta = 1.82 × 10-9 for rs2732552. The AA and Asian SLE cases also demonstrated association at rs2732552 (p = 5 × 10-3, OR = 0.81 and p = 4.3 × 10-4, OR = 0.80, respectively). A meta-analysis of rs2732552 for all racial and ethnic groups studied produced pmeta = 2.36 × 10-13. This locus contains multiple regulatory sites that could potentially affect expression and functions of CD44, a cell-surface glycoprotein influencing immunologic, inflammatory, and oncologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex. © 2011 The American Society of Human Genetics.
publishDate 2011
dc.date.created.none.fl_str_mv 2011
dc.date.issued.none.fl_str_mv 2011
dc.date.accessioned.none.fl_str_mv 2018-11-29T14:09:24Z
dc.date.available.none.fl_str_mv 2018-11-29T14:09:24Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN 0002-9297
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identifier_str_mv ISSN 0002-9297
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dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationStartPage.none.fl_str_mv 83
dc.relation.citationTitle.none.fl_str_mv American Journal of Human Genetics
dc.relation.citationVolume.none.fl_str_mv Vol. 88
dc.relation.ispartof.spa.fl_str_mv American Journal of Human Genetics, ISSN: 0002-9297, Vol. 88/No. 1 (2011) pp. 83-91
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dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-license
rights_invalid_str_mv Abierto (Texto Completo)
https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-license
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Moser, K.L., Kelly, J.A., Lessard, C.J., Harley, J.B., Recent insights into the genetic basis of systemic lupus erythematosus (2009) Genes Immun., 10, pp. 373-379
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
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We sought to replicate a putative association at 11p13 not yet exceeding genome-wide significance (p < 5 × 10-8) identified in a genome-wide association study (GWAS). Our GWA scan identified two intergenic SNPs located between PDHX and CD44 showing suggestive evidence of association with SLE in cases of European descent (rs2732552, p = 0.004, odds ratio [OR] = 0.78; rs387619, p = 0.003, OR = 0.78). The replication cohort consisted of >15,000 subjects, including 3562 SLE cases and 3491 controls of European ancestry, 1527 cases and 1811 controls of African American (AA) descent, and 1265 cases and 1260 controls of Asian origin. We observed robust association at both rs2732552 (p = 9.03 × 10-8, OR = 0.83) and rs387619 (p = 7.7 × 10-7, OR = 0.83) in the European samples with pmeta = 1.82 × 10-9 for rs2732552. The AA and Asian SLE cases also demonstrated association at rs2732552 (p = 5 × 10-3, OR = 0.81 and p = 4.3 × 10-4, OR = 0.80, respectively). A meta-analysis of rs2732552 for all racial and ethnic groups studied produced pmeta = 2.36 × 10-13. This locus contains multiple regulatory sites that could potentially affect expression and functions of CD44, a cell-surface glycoprotein influencing immunologic, inflammatory, and oncologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex. © 2011 The American Society of Human Genetics.application/pdfISSN 0002-9297http://repository.urosario.edu.co/handle/10336/18752eng91No. 183American Journal of Human GeneticsVol. 88American Journal of Human Genetics, ISSN: 0002-9297, Vol. 88/No. 1 (2011) pp. 83-91https://ac.els-cdn.com/S0002929710006014/1-s2.0-S0002929710006014-main.pdf?_tid=3a3b3608-0ceb-4cbd-a36b-a4b96f664c62&acdnat=1540058212_4b380053c89c72215bdc4c10cf96e29aAbierto (Texto Completo)https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-licensehttp://purl.org/coar/access_right/c_abf2Moser, K.L., Kelly, J.A., Lessard, C.J., Harley, J.B., Recent insights into the genetic basis of systemic lupus erythematosus (2009) Genes Immun., 10, pp. 373-379instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCd44V AntigenCd44Single NucleotideHumanPyruvate Dehydrogenase ComplexPair 11African AmericanAmerican IndianAsianCaucasianChromosome 11PCohort AnalysisControlled StudyGene LocusGenetic AssociationGenetic SusceptibilityHispanicHumanMajor Clinical StudyMaleMeta AnalysisPriority JournalSingle Nucleotide PolymorphismStatistical AnalysisSystemic Lupus ErythematosusAfrican AmericansAmerican Native Continental Ancestry GroupAntigensAsian Continental Ancestry GroupChromosomesCohort StudiesEuropean Continental Ancestry GroupGenetic LociGenetic Predisposition To DiseaseHaplotypesHispanic AmericansLinkage DisequilibriumMalePolymorphismPyruvate Dehydrogenase ComplexSystemicLupus ErythematosusArticleFemaleFemaleHumansLupus Eritomatoso SistémicoEnfermedades autoinmunesEnfermedades de la pielIdentification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Lessard, Christopher J.Adrianto, IndraKelly, Jennifer A.Kaufman, Kenneth M.Grundahl, Kiely M.Adler, AdamWilliams, Adrienne H.Gallant, Caroline J.Alarcón-Riquelme, Marta E.Anaya, Juan-ManuelBae, Sang-CheolBoackle, SusanBrown, Elizabeth E.Chang, Deh-MingCriswel, Lindsey A.Edberg, Jeffrey C.Freedman, Barry I.Gregersen, Peter K.Gilkeson, Gary S.Jacob, Chaim O.James, Judith A.Kamen, Diane L.Kimberly, Robert P.Martin, JavierMerrill, Joan T.Niewold, Timothy B.Park, So-YeonPetri, Michelle A.Pons-Estel, Bernardo A.Ramsey-Goldman, RosalindReveille, John D.Song, Yeong WookStevens, Anne M.Tsao, Betty P.Vila, Luis M.Vyse, Timothy J.Yu, Chack-YungGuthridge, Joel M.Bruner, Gail R.Langefeld, Carl D.Montgomery, CourtneyHarley, John B.Scofield, Robert H.Gaffney, Patrick M.Moser, Kathy L.Lessard, Christopher J.Adrianto, IndraKelly, Jennifer A.Kaufman, Kenneth M.Grundahl, Kiely M.Adler, AdamWilliams, Adrienne H.Gallant, Caroline J.Alarcón-Riquelme, Marta E.Anaya, Juan-ManuelBae, Sang-CheolBoackle, Susan A.Brown, Elizabeth E.Chang, Deh-MingCriswel, Lindsey A.Edberg, Jeffrey C.Freedman, Barry I.Gregersen, Peter K.Gilkeson, Gary S.Jacob, Chaim O.James, Judith A.Kamen, Diane L.Kimberly, Robert P.Martin, JavierMerrill, Joan T.Niewold, Timothy B.Park, So-YeonPetri, Michelle A.Pons-Estel, Bernardo A.Ramsey-Goldman, RosalindReveille, John D.Song, Yeong WookStevens, Anne M.Tsao, Betty P.Vila, Luis M.Vyse, Timothy J.Yu, Chack-YungGuthridge, Joel M.Langefeld, Carl D.Montgomery, CourtneyHarley, John B.Scofield, R. HalScofield, R. HalGaffney, Patrick M.Moser, Kathy L.ORIGINAL144.pdfapplication/pdf847772https://repository.urosario.edu.co/bitstreams/dc22b272-eac4-42bb-bffe-bd65153a1e37/download74d4483261ba368a60f9de4d5e1be7bcMD51TEXT144.pdf.txt144.pdf.txtExtracted texttext/plain38994https://repository.urosario.edu.co/bitstreams/1ab11a45-705b-4297-ad0c-e541b5c00b88/downloadc65b8c2c330a056fb51bc8b7f4bfe0ebMD52THUMBNAIL144.pdf.jpg144.pdf.jpgGenerated Thumbnailimage/jpeg4718https://repository.urosario.edu.co/bitstreams/80b53a47-b854-4757-a64a-7cc0daeb8c74/download109879193080284eb8a3b2429739648dMD5310336/18752oai:repository.urosario.edu.co:10336/187522019-09-19 07:38:03.190837https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-licensehttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co