Identification of transcriptomic responses related to normal, healthy and accelerated aging

El envejecimiento es la reducción de las capacidades fisiológicas y adaptativas del organismo con el paso del tiempo. La acumulación de daño en el ADN podría ser el evento central desencadenante del proceso de envejecimiento. Los síndromes progeroides causados por una deficiencia de la sub-vía de re...

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Fecha de publicación:: 2018

Institución:: Universidad del Rosario

Repositorio:: Repositorio EdocUR - U. Rosario

Idioma:: spa

id	EDOCUR2_54e920654ca114286d90e3caddc9b3aa
oai_identifier_str	oai:repository.urosario.edu.co:10336/19101
network_acronym_str	EDOCUR2
network_name_str	Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv	Identification of transcriptomic responses related to normal, healthy and accelerated aging
title	Identification of transcriptomic responses related to normal, healthy and accelerated aging
spellingShingle	Identification of transcriptomic responses related to normal, healthy and accelerated aging Envejecimiento Transcriptomica Expectativa de vida Respuesta protectora Estrés agudo Daño en el ADN Parkinson Fisiología humana Aging DNA damage lifespan protective response Parkinson Envejecimiento ADN Expectativa de vida
title_short	Identification of transcriptomic responses related to normal, healthy and accelerated aging
title_full	Identification of transcriptomic responses related to normal, healthy and accelerated aging
title_fullStr	Identification of transcriptomic responses related to normal, healthy and accelerated aging
title_full_unstemmed	Identification of transcriptomic responses related to normal, healthy and accelerated aging
title_sort	Identification of transcriptomic responses related to normal, healthy and accelerated aging
dc.contributor.advisor.none.fl_str_mv	Ramírez Clavijo, Sandra Rocío
dc.subject.spa.fl_str_mv	Envejecimiento Transcriptomica Expectativa de vida Respuesta protectora Estrés agudo Daño en el ADN Parkinson
topic	Envejecimiento Transcriptomica Expectativa de vida Respuesta protectora Estrés agudo Daño en el ADN Parkinson Fisiología humana Aging DNA damage lifespan protective response Parkinson Envejecimiento ADN Expectativa de vida
dc.subject.ddc.spa.fl_str_mv	Fisiología humana
dc.subject.keyword.spa.fl_str_mv	Aging DNA damage lifespan protective response Parkinson
dc.subject.lemb.spa.fl_str_mv	Envejecimiento ADN Expectativa de vida
description	El envejecimiento es la reducción de las capacidades fisiológicas y adaptativas del organismo con el paso del tiempo. La acumulación de daño en el ADN podría ser el evento central desencadenante del proceso de envejecimiento. Los síndromes progeroides causados por una deficiencia de la sub-vía de reparación de escisión de nucleótidos acoplada a transcripción (TCR-NER) presentan un vínculo directo entre daño en el ADN y envejecimiento. Hay un paralelo entre la respuesta transcripcional de ratones progeroides y ratones sometidos a restricción dietética (DR) (una intervención que prolonga la vida). La DR aumenta la resistencia a diferentes formas de estrés. Ratones deficientes en TCR-NER también son menos susceptibles a un tipo de estrés agudo. El paralelo entre las respuestas transcriptómicas de los animales en dos extremos de esperanza de vida se ha explicado por la existencia de una respuesta de supervivencia programada. Esta tesis aborda varias cuestiones relacionadas con la respuesta de supervivencia utilizando principalmente el análisis de datos transcriptómicos. Primero, se estableció que los ratones viejos activan una respuesta de supervivencia incompleta después de tres días de DR, en segundo lugar, se describió un mecanismo común de activación de la respuesta protectora. En tercer lugar, se proporcionó una conexión entre la acumulación de daño en el ADN y la neurodegeneración. Finalmente, por medio de una metodología de análisis integrador sobre datos de transcriptómica de cerebro humano se encontró que en envejecimiento normal los astrocitos desarrollan dos fenotipos opuestos.
publishDate	2018
dc.date.created.none.fl_str_mv	2018-12-14
dc.date.issued.none.fl_str_mv	2018
dc.date.accessioned.none.fl_str_mv	2019-02-18T22:27:12Z
dc.date.available.none.fl_str_mv	2019-02-18T22:27:12Z
dc.type.eng.fl_str_mv	doctoralThesis
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.document.spa.fl_str_mv	Tesis
dc.type.spa.spa.fl_str_mv	Tesis de doctorado
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.48713/10336_19101
dc.identifier.uri.none.fl_str_mv	http://repository.urosario.edu.co/handle/10336/19101
url	https://doi.org/10.48713/10336_19101 http://repository.urosario.edu.co/handle/10336/19101
dc.language.iso.none.fl_str_mv	spa
language	spa
dc.rights.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv	Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv	Atribución-NoComercial-SinDerivadas 2.5 Colombia Abierto (Texto Completo) http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Universidad del Rosario
dc.publisher.department.spa.fl_str_mv	Facultad de Ciencias Naturales y Matemáticas
dc.publisher.program.spa.fl_str_mv	Doctorado en Ciencias Biomédicas
institution	Universidad del Rosario
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spelling	Ramírez Clavijo, Sandra Rocío51866251600Payan-Gomez, CesarDoctor en Ciencias BiomédicasFull time763272336002019-02-18T22:27:12Z2019-02-18T22:27:12Z2018-12-142018El envejecimiento es la reducción de las capacidades fisiológicas y adaptativas del organismo con el paso del tiempo. La acumulación de daño en el ADN podría ser el evento central desencadenante del proceso de envejecimiento. Los síndromes progeroides causados por una deficiencia de la sub-vía de reparación de escisión de nucleótidos acoplada a transcripción (TCR-NER) presentan un vínculo directo entre daño en el ADN y envejecimiento. Hay un paralelo entre la respuesta transcripcional de ratones progeroides y ratones sometidos a restricción dietética (DR) (una intervención que prolonga la vida). La DR aumenta la resistencia a diferentes formas de estrés. Ratones deficientes en TCR-NER también son menos susceptibles a un tipo de estrés agudo. El paralelo entre las respuestas transcriptómicas de los animales en dos extremos de esperanza de vida se ha explicado por la existencia de una respuesta de supervivencia programada. Esta tesis aborda varias cuestiones relacionadas con la respuesta de supervivencia utilizando principalmente el análisis de datos transcriptómicos. Primero, se estableció que los ratones viejos activan una respuesta de supervivencia incompleta después de tres días de DR, en segundo lugar, se describió un mecanismo común de activación de la respuesta protectora. En tercer lugar, se proporcionó una conexión entre la acumulación de daño en el ADN y la neurodegeneración. Finalmente, por medio de una metodología de análisis integrador sobre datos de transcriptómica de cerebro humano se encontró que en envejecimiento normal los astrocitos desarrollan dos fenotipos opuestos.Aging is defined as the reduction in the physiological and adaptive capabilities of organisms with the passage of time. The accumulation of DNA damage could be the central event on which other factors related to the aging process coalesce. One of the links connecting DNA damage to aging are the progeroid syndromes caused by a deficiency of DNA transcription-coupled nucleotide excision repair (TCR-NER) subpathway. There is a parallel between the transcriptional response of progeroid mice and mice on a dietary restriction (DR) regimen (an intervention that extend the lifespan). DR increased resistance to different forms of acute stress. Corroborating that TCR-NER deficiency induces activation of similar protective mechanisms, Csb-/- and Csa-/- mice are less susceptible to renal ischemia-reperfusion injury. The parallel between the transcriptomic responses of animals at two life expectancy extremes, in addition to the shared increase in resistance to ischemia-reperfusion injury, has been explained by the existence of a programmed survival response. This thesis addresses several questions related with the survival response, the mechanism of neurodegeneration and normal aging using mainly analysis of transcriptomic data. First, it was established that old mice activate an incomplete survival response after three days of DR, second, a common mechanism of activation of the protective response was described. Third, a connection between the accumulation of DNA damage and neurodegeneration was provided. Finally, an integrative methodology of analysis was used over brain human transcriptomic data, the result was the identification of an opposite activation of astrocytes in the human aged prefrontal cortex.application/pdfhttps://doi.org/10.48713/10336_19101 http://repository.urosario.edu.co/handle/10336/19101spaUniversidad del RosarioFacultad de Ciencias Naturales y MatemáticasDoctorado en Ciencias BiomédicasAtribución-NoComercial-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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Identification of transcriptomic responses related to normal, healthy and accelerated aging

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