Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria
Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2003
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26739
- Acceso en línea:
- https://doi.org/10.1016/S0300-9084(03)00136-6
https://repository.urosario.edu.co/handle/10336/26739
- Palabra clave:
- Malaria
Peptides
SERA protein
Structure
Vaccine
- Rights
- License
- Restringido (Acceso a grupos específicos)
| Summary: | Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides’ secondary structure and their function as immunogen against malaria. |
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