Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin

Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditi...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23566
Acceso en línea:
https://doi.org/10.1186/s12879-018-3613-8
https://repository.urosario.edu.co/handle/10336/23566
Palabra clave:
Antiinflammatory agent
Antiparasitic agent
Antiretrovirus agent
Immunomodulating agent
Tuberculostatic agent
Valganciclovir
Virus dna
Adolescent
Adult
Aged
Aqueous humor
Article
Blood sampling
Clinical examination
Colombia
Colombian
Cytomegalovirus infection
Descriptive research
Diagnostic test
Differential diagnosis
Drug substitution
Drug withdrawal
Epstein barr virus infection
Female
Goldmann witmer coefficient
Herpes simplex virus 2
Herpes zoster
Herpes zoster ophthalmicus
Human
Human alphaherpesvirus 1
Immunocompetence
Laboratory test
Major clinical study
Male
Mixed infection
Nonhuman
Ocular toxoplasmosis
Ocular tuberculosis
Polymerase chain reaction
Serum
Uveitis
Vitreous body
Complication
Cytomegalovirus
Differential diagnosis
Genetics
Herpes virus infection
Immunocompetence
Immunology
Middle aged
Mixed infection
Parasitic eye infection
Toxoplasmosis
Viral eye infection
Virology
Young adult
Adolescent
Adult
Aged
Coinfection
Colombia
Cytomegalovirus
Female
Herpesviridae infections
Humans
Immunocompetence
Male
Middle aged
Polymerase chain reaction
Toxoplasmosis
Young adult
Co-infections
Diagnosis
Goldmann-witmer
Immunocompetent
Ocular toxoplasmosis
Pcr
viral
differential
parasitic
viral
Diagnosis
Dna
Eye infections
Eye infections
Rights
License
Abierto (Texto Completo)
id EDOCUR2_4f0960de856b46fe2b10bc31e223328f
oai_identifier_str oai:repository.urosario.edu.co:10336/23566
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
title Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
spellingShingle Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
Antiinflammatory agent
Antiparasitic agent
Antiretrovirus agent
Immunomodulating agent
Tuberculostatic agent
Valganciclovir
Virus dna
Adolescent
Adult
Aged
Aqueous humor
Article
Blood sampling
Clinical examination
Colombia
Colombian
Cytomegalovirus infection
Descriptive research
Diagnostic test
Differential diagnosis
Drug substitution
Drug withdrawal
Epstein barr virus infection
Female
Goldmann witmer coefficient
Herpes simplex virus 2
Herpes zoster
Herpes zoster ophthalmicus
Human
Human alphaherpesvirus 1
Immunocompetence
Laboratory test
Major clinical study
Male
Mixed infection
Nonhuman
Ocular toxoplasmosis
Ocular tuberculosis
Polymerase chain reaction
Serum
Uveitis
Vitreous body
Complication
Cytomegalovirus
Differential diagnosis
Genetics
Herpes virus infection
Immunocompetence
Immunology
Middle aged
Mixed infection
Parasitic eye infection
Toxoplasmosis
Viral eye infection
Virology
Young adult
Adolescent
Adult
Aged
Coinfection
Colombia
Cytomegalovirus
Female
Herpesviridae infections
Humans
Immunocompetence
Male
Middle aged
Polymerase chain reaction
Toxoplasmosis
Young adult
Co-infections
Diagnosis
Goldmann-witmer
Immunocompetent
Ocular toxoplasmosis
Pcr
viral
differential
parasitic
viral
Diagnosis
Dna
Eye infections
Eye infections
title_short Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
title_full Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
title_fullStr Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
title_full_unstemmed Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
title_sort Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
dc.subject.keyword.spa.fl_str_mv Antiinflammatory agent
Antiparasitic agent
Antiretrovirus agent
Immunomodulating agent
Tuberculostatic agent
Valganciclovir
Virus dna
Adolescent
Adult
Aged
Aqueous humor
Article
Blood sampling
Clinical examination
Colombia
Colombian
Cytomegalovirus infection
Descriptive research
Diagnostic test
Differential diagnosis
Drug substitution
Drug withdrawal
Epstein barr virus infection
Female
Goldmann witmer coefficient
Herpes simplex virus 2
Herpes zoster
Herpes zoster ophthalmicus
Human
Human alphaherpesvirus 1
Immunocompetence
Laboratory test
Major clinical study
Male
Mixed infection
Nonhuman
Ocular toxoplasmosis
Ocular tuberculosis
Polymerase chain reaction
Serum
Uveitis
Vitreous body
Complication
Cytomegalovirus
Differential diagnosis
Genetics
Herpes virus infection
Immunocompetence
Immunology
Middle aged
Mixed infection
Parasitic eye infection
Toxoplasmosis
Viral eye infection
Virology
Young adult
Adolescent
Adult
Aged
Coinfection
Colombia
Cytomegalovirus
Female
Herpesviridae infections
Humans
Immunocompetence
Male
Middle aged
Polymerase chain reaction
Toxoplasmosis
Young adult
Co-infections
Diagnosis
Goldmann-witmer
Immunocompetent
Ocular toxoplasmosis
Pcr
topic Antiinflammatory agent
Antiparasitic agent
Antiretrovirus agent
Immunomodulating agent
Tuberculostatic agent
Valganciclovir
Virus dna
Adolescent
Adult
Aged
Aqueous humor
Article
Blood sampling
Clinical examination
Colombia
Colombian
Cytomegalovirus infection
Descriptive research
Diagnostic test
Differential diagnosis
Drug substitution
Drug withdrawal
Epstein barr virus infection
Female
Goldmann witmer coefficient
Herpes simplex virus 2
Herpes zoster
Herpes zoster ophthalmicus
Human
Human alphaherpesvirus 1
Immunocompetence
Laboratory test
Major clinical study
Male
Mixed infection
Nonhuman
Ocular toxoplasmosis
Ocular tuberculosis
Polymerase chain reaction
Serum
Uveitis
Vitreous body
Complication
Cytomegalovirus
Differential diagnosis
Genetics
Herpes virus infection
Immunocompetence
Immunology
Middle aged
Mixed infection
Parasitic eye infection
Toxoplasmosis
Viral eye infection
Virology
Young adult
Adolescent
Adult
Aged
Coinfection
Colombia
Cytomegalovirus
Female
Herpesviridae infections
Humans
Immunocompetence
Male
Middle aged
Polymerase chain reaction
Toxoplasmosis
Young adult
Co-infections
Diagnosis
Goldmann-witmer
Immunocompetent
Ocular toxoplasmosis
Pcr
viral
differential
parasitic
viral
Diagnosis
Dna
Eye infections
Eye infections
dc.subject.keyword.eng.fl_str_mv viral
differential
parasitic
viral
Diagnosis
Dna
Eye infections
Eye infections
description Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools. Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Aqueous humor (AH) and/or vitreous fluid, blood and serum samples were collected from consecutive patients suspected of having infectious uveitis. The diagnosis of ocular toxoplasmosis (OT) was confirmed by the Goldmann-Witmer coefficient (GWC) and by polymerase chain reaction (PCR). Differential diagnosis by PCR in AH was done for viral origin such as Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV1), Herpes simplex virus type 2 (HSV2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and Mycobacterium tuberculosis. Results: In 66 Colombian patients with uveitis of presumed infectious origin: 22 (33.3%) were confirmed as OT, 16 (24.2%) as undetermined OT, five (7.5%) as co-infections and 23 (34.8%) as other uveitis. Toxoplasma coinfection with M. tuberculosis was identified in one case by PCR and in four cases with HSV by GWC. The initial clinical diagnosis changed, after laboratory examination, in 21 cases (31.8%). Conclusions: Clinical diagnosis can be changed by laboratory examination in a significant proportion of cases of uveitis. Diagnosis of OT should combine the use of PCR and GWC to reach the maximum of confirmation of cases. The use of multiple laboratory methods is necessary to identify co-infections and viral infections that can mimic OT in immunocompetent patients. © 2019 The Author(s).
publishDate 2019
dc.date.created.spa.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:03:09Z
dc.date.available.none.fl_str_mv 2020-05-26T00:03:09Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1186/s12879-018-3613-8
dc.identifier.issn.none.fl_str_mv 14712334
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23566
url https://doi.org/10.1186/s12879-018-3613-8
https://repository.urosario.edu.co/handle/10336/23566
identifier_str_mv 14712334
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationTitle.none.fl_str_mv BMC Infectious Diseases
dc.relation.citationVolume.none.fl_str_mv Vol. 19
dc.relation.ispartof.spa.fl_str_mv BMC Infectious Diseases, ISSN:14712334, Vol.19, No.1 (2019)
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060537408&doi=10.1186%2fs12879-018-3613-8&partnerID=40&md5=db6d57e7b3f2119216eba00708eb54db
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv BioMed Central Ltd.
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
bitstream.url.fl_str_mv https://repository.urosario.edu.co/bitstreams/3cc74ebd-b2cb-45b7-b5f5-deee569990ee/download
https://repository.urosario.edu.co/bitstreams/47e84643-cb87-429a-b523-320370f77111/download
https://repository.urosario.edu.co/bitstreams/43cec55b-aa21-4142-8727-ccfab139032f/download
bitstream.checksum.fl_str_mv f06af3f6ef0d7cc25a5661341d2e33a1
5e46697efb49b001dafff26cba4b629f
ec08af658b0b83ac7e1bac3d39d11a6a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167458546712576
spelling 51701355600e389509b-aa90-4693-9cb5-373e78f26c0f8d6337a9-2371-409d-ae17-1f3e393d241ec4c6659f-afac-4934-b360-526c2cbe5b17b19280cc-6b8c-4e96-8307-93786c488d04a6683a71-fd21-4025-b6c9-2cdc1b47c6adfae9adfa-59a0-4f8f-ac0d-02aeb54918e5a92dd30e-6b14-475b-9019-af4ecb1e37b2e3ce2dbc-3453-4f3e-9ac3-6c6836d1cf9bb7dc59dc-b402-468b-ba2c-edc7b4d90ed8b69e130b-4954-475a-b3c9-3d695ec6d7236829ab02-cdf8-48b0-a9c7-09e3cbbccbd476d3629d-cffa-408d-91db-15cf139af24b2020-05-26T00:03:09Z2020-05-26T00:03:09Z2019Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools. Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Aqueous humor (AH) and/or vitreous fluid, blood and serum samples were collected from consecutive patients suspected of having infectious uveitis. The diagnosis of ocular toxoplasmosis (OT) was confirmed by the Goldmann-Witmer coefficient (GWC) and by polymerase chain reaction (PCR). Differential diagnosis by PCR in AH was done for viral origin such as Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV1), Herpes simplex virus type 2 (HSV2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and Mycobacterium tuberculosis. Results: In 66 Colombian patients with uveitis of presumed infectious origin: 22 (33.3%) were confirmed as OT, 16 (24.2%) as undetermined OT, five (7.5%) as co-infections and 23 (34.8%) as other uveitis. Toxoplasma coinfection with M. tuberculosis was identified in one case by PCR and in four cases with HSV by GWC. The initial clinical diagnosis changed, after laboratory examination, in 21 cases (31.8%). Conclusions: Clinical diagnosis can be changed by laboratory examination in a significant proportion of cases of uveitis. Diagnosis of OT should combine the use of PCR and GWC to reach the maximum of confirmation of cases. The use of multiple laboratory methods is necessary to identify co-infections and viral infections that can mimic OT in immunocompetent patients. © 2019 The Author(s).application/pdfhttps://doi.org/10.1186/s12879-018-3613-814712334https://repository.urosario.edu.co/handle/10336/23566engBioMed Central Ltd.No. 1BMC Infectious DiseasesVol. 19BMC Infectious Diseases, ISSN:14712334, Vol.19, No.1 (2019)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060537408&doi=10.1186%2fs12879-018-3613-8&partnerID=40&md5=db6d57e7b3f2119216eba00708eb54dbAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAntiinflammatory agentAntiparasitic agentAntiretrovirus agentImmunomodulating agentTuberculostatic agentValganciclovirVirus dnaAdolescentAdultAgedAqueous humorArticleBlood samplingClinical examinationColombiaColombianCytomegalovirus infectionDescriptive researchDiagnostic testDifferential diagnosisDrug substitutionDrug withdrawalEpstein barr virus infectionFemaleGoldmann witmer coefficientHerpes simplex virus 2Herpes zosterHerpes zoster ophthalmicusHumanHuman alphaherpesvirus 1ImmunocompetenceLaboratory testMajor clinical studyMaleMixed infectionNonhumanOcular toxoplasmosisOcular tuberculosisPolymerase chain reactionSerumUveitisVitreous bodyComplicationCytomegalovirusDifferential diagnosisGeneticsHerpes virus infectionImmunocompetenceImmunologyMiddle agedMixed infectionParasitic eye infectionToxoplasmosisViral eye infectionVirologyYoung adultAdolescentAdultAgedCoinfectionColombiaCytomegalovirusFemaleHerpesviridae infectionsHumansImmunocompetenceMaleMiddle agedPolymerase chain reactionToxoplasmosisYoung adultCo-infectionsDiagnosisGoldmann-witmerImmunocompetentOcular toxoplasmosisPcrviraldifferentialparasiticviralDiagnosisDnaEye infectionsEye infectionsCoinfections and differential diagnosis in immunocompetent patients with uveitis of infectious originarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501de-la-Torre, AlejandraValdés-Camacho, Juanitade Mesa, Clara LópezUauy-Nazal, AndrésZuluaga, Juan DavidRamírez-Páez, Lina MaríaDurán, FelipeTorres-Morales, ElizabethTriviño, JessicaMurillo, MateoPeñaranda, Alba CristinaSepúlveda-Arias, Juan CarlosGómez-Marín, Jorge EnriqueORIGINALs12879-018-3613-8.pdfapplication/pdf1274181https://repository.urosario.edu.co/bitstreams/3cc74ebd-b2cb-45b7-b5f5-deee569990ee/downloadf06af3f6ef0d7cc25a5661341d2e33a1MD51TEXTs12879-018-3613-8.pdf.txts12879-018-3613-8.pdf.txtExtracted texttext/plain48033https://repository.urosario.edu.co/bitstreams/47e84643-cb87-429a-b523-320370f77111/download5e46697efb49b001dafff26cba4b629fMD52THUMBNAILs12879-018-3613-8.pdf.jpgs12879-018-3613-8.pdf.jpgGenerated Thumbnailimage/jpeg4664https://repository.urosario.edu.co/bitstreams/43cec55b-aa21-4142-8727-ccfab139032f/downloadec08af658b0b83ac7e1bac3d39d11a6aMD5310336/23566oai:repository.urosario.edu.co:10336/235662022-05-02 07:37:15.970972https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co