Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2010
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/8812
- Acceso en línea:
- http://repository.urosario.edu.co/handle/10336/8812
- Palabra clave:
- Incidencia & prevención de la enfermedad
Malaria
Enfermedades autoinmunes
Enfermedades infecciosas
Inmunología
PLASMODIUM-FALCIPARUM MALARIA
MEROZOITE SURFACE PROTEIN-1
SOLID-PHASE SYNTHESIS
MHC CLASS-II
CRYSTAL-STRUCTURE
AMINO-ACIDS
SYNTHETIC PEPTIDES
IMMUNE EVASION
BOND ANALOG
RECOGNITION
- Rights
- License
- Abierto (Texto completo)
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oai:repository.urosario.edu.co:10336/8812 |
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EDOCUR2 |
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Repositorio EdocUR - U. Rosario |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
title |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
spellingShingle |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria Incidencia & prevención de la enfermedad Malaria Enfermedades autoinmunes Enfermedades infecciosas Inmunología PLASMODIUM-FALCIPARUM MALARIA MEROZOITE SURFACE PROTEIN-1 SOLID-PHASE SYNTHESIS MHC CLASS-II CRYSTAL-STRUCTURE AMINO-ACIDS SYNTHETIC PEPTIDES IMMUNE EVASION BOND ANALOG RECOGNITION |
title_short |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
title_full |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
title_fullStr |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
title_full_unstemmed |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
title_sort |
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria |
dc.subject.ddc.none.fl_str_mv |
Incidencia & prevención de la enfermedad |
topic |
Incidencia & prevención de la enfermedad Malaria Enfermedades autoinmunes Enfermedades infecciosas Inmunología PLASMODIUM-FALCIPARUM MALARIA MEROZOITE SURFACE PROTEIN-1 SOLID-PHASE SYNTHESIS MHC CLASS-II CRYSTAL-STRUCTURE AMINO-ACIDS SYNTHETIC PEPTIDES IMMUNE EVASION BOND ANALOG RECOGNITION |
dc.subject.decs.spa.fl_str_mv |
Malaria Enfermedades autoinmunes Enfermedades infecciosas Inmunología |
dc.subject.keyword.eng.fl_str_mv |
PLASMODIUM-FALCIPARUM MALARIA MEROZOITE SURFACE PROTEIN-1 SOLID-PHASE SYNTHESIS MHC CLASS-II CRYSTAL-STRUCTURE AMINO-ACIDS SYNTHETIC PEPTIDES IMMUNE EVASION BOND ANALOG RECOGNITION |
description |
Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria. |
publishDate |
2010 |
dc.date.created.none.fl_str_mv |
2010-12 |
dc.date.issued.none.fl_str_mv |
2010 |
dc.date.accessioned.none.fl_str_mv |
2014-08-12T16:59:41Z |
dc.date.available.none.fl_str_mv |
2014-08-12T16:59:41Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
ISSN:1420-3049 |
dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/8812 |
identifier_str_mv |
ISSN:1420-3049 |
url |
http://repository.urosario.edu.co/handle/10336/8812 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 12 |
dc.relation.citationTitle.none.fl_str_mv |
MOLECULES |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 15 |
dc.relation.ispartof.spa.fl_str_mv |
MOLECULES ISSN: 1420-3049 V. 15 N. 12 Dic, 2010 |
dc.relation.uri.none.fl_str_mv |
http://www.mdpi.com/1420-3049/15/12/8856 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto completo) |
rights_invalid_str_mv |
Abierto (Texto completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.medium.spa.fl_str_mv |
Recurso electrónico |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.format.tipo.spa.fl_str_mv |
Documento |
dc.publisher.spa.fl_str_mv |
Universidad del Rosario |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
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spelling |
Comunidad Rosaristada84bf35-67ee-4a8b-9fc7-af2e7f1bc0736002c1f11ba-edb4-4498-a3ef-6813708a8870600e8a0b416-2668-4440-9311-046ba68a3ff2600f3cd7e5b-e48c-40f7-a970-0399b90bb8756009e3ba9df-fe89-48fe-9521-cc8f452d56f56002014-08-12T16:59:41Z2014-08-12T16:59:41Z2010-122010Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.Recurso electrónicoapplication/pdfDocumentoISSN:1420-3049http://repository.urosario.edu.co/handle/10336/8812engUniversidad del RosarioNo. 12MOLECULESVol. 15MOLECULES ISSN: 1420-3049 V. 15 N. 12 Dic, 2010http://www.mdpi.com/1420-3049/15/12/8856Abierto (Texto completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURIncidencia & prevención de la enfermedad614600MalariaEnfermedades autoinmunesEnfermedades infecciosasInmunologíaPLASMODIUM-FALCIPARUM MALARIAMEROZOITE SURFACE PROTEIN-1SOLID-PHASE SYNTHESISMHC CLASS-IICRYSTAL-STRUCTUREAMINO-ACIDSSYNTHETIC PEPTIDESIMMUNE EVASIONBOND ANALOGRECOGNITIONDevelopment of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malariaarticleArtículohttp://purl.org/coar/resource_type/c_6501Lozano, Jose ManuelLesmes, Liliana PCarreno, LuisaGallego, Gina M.Patarroyo, Manuel E.Lozano, José ManuelLesmes, Liliana P.Carreño, Luisa F.Gallego, Gina M.Patarroyo, Manuel ElkinORIGINALmolecules-15.pdfmolecules-15.pdfapplication/pdf1153147https://repository.urosario.edu.co/bitstreams/49519f0b-f85d-4b97-adb5-abaf012d623a/download81672c5a4bd70ee3bd47b6695d148bedMD51LICENSElicense.txtlicense.txttext/plain2156https://repository.urosario.edu.co/bitstreams/b5ba716e-022b-46bd-bae1-b2f080be6890/downloadb4f8fe66e94b897ab4c355bac005ad16MD52TEXTmolecules-15.pdf.txtmolecules-15.pdf.txtExtracted 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