Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria

Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting...

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Autores:
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/8812
Acceso en línea:
http://repository.urosario.edu.co/handle/10336/8812
Palabra clave:
Incidencia & prevención de la enfermedad
Malaria
Enfermedades autoinmunes
Enfermedades infecciosas
Inmunología
PLASMODIUM-FALCIPARUM MALARIA
MEROZOITE SURFACE PROTEIN-1
SOLID-PHASE SYNTHESIS
MHC CLASS-II
CRYSTAL-STRUCTURE
AMINO-ACIDS
SYNTHETIC PEPTIDES
IMMUNE EVASION
BOND ANALOG
RECOGNITION
Rights
License
Abierto (Texto completo)
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dc.title.spa.fl_str_mv Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
title Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
spellingShingle Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
Incidencia & prevención de la enfermedad
Malaria
Enfermedades autoinmunes
Enfermedades infecciosas
Inmunología
PLASMODIUM-FALCIPARUM MALARIA
MEROZOITE SURFACE PROTEIN-1
SOLID-PHASE SYNTHESIS
MHC CLASS-II
CRYSTAL-STRUCTURE
AMINO-ACIDS
SYNTHETIC PEPTIDES
IMMUNE EVASION
BOND ANALOG
RECOGNITION
title_short Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
title_full Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
title_fullStr Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
title_full_unstemmed Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
title_sort Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
dc.subject.ddc.none.fl_str_mv Incidencia & prevención de la enfermedad
topic Incidencia & prevención de la enfermedad
Malaria
Enfermedades autoinmunes
Enfermedades infecciosas
Inmunología
PLASMODIUM-FALCIPARUM MALARIA
MEROZOITE SURFACE PROTEIN-1
SOLID-PHASE SYNTHESIS
MHC CLASS-II
CRYSTAL-STRUCTURE
AMINO-ACIDS
SYNTHETIC PEPTIDES
IMMUNE EVASION
BOND ANALOG
RECOGNITION
dc.subject.decs.spa.fl_str_mv Malaria
Enfermedades autoinmunes
Enfermedades infecciosas
Inmunología
dc.subject.keyword.eng.fl_str_mv PLASMODIUM-FALCIPARUM MALARIA
MEROZOITE SURFACE PROTEIN-1
SOLID-PHASE SYNTHESIS
MHC CLASS-II
CRYSTAL-STRUCTURE
AMINO-ACIDS
SYNTHETIC PEPTIDES
IMMUNE EVASION
BOND ANALOG
RECOGNITION
description Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.
publishDate 2010
dc.date.created.none.fl_str_mv 2010-12
dc.date.issued.none.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2014-08-12T16:59:41Z
dc.date.available.none.fl_str_mv 2014-08-12T16:59:41Z
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN:1420-3049
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/8812
identifier_str_mv ISSN:1420-3049
url http://repository.urosario.edu.co/handle/10336/8812
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.citationIssue.none.fl_str_mv No. 12
dc.relation.citationTitle.none.fl_str_mv MOLECULES
dc.relation.citationVolume.none.fl_str_mv Vol. 15
dc.relation.ispartof.spa.fl_str_mv MOLECULES ISSN: 1420-3049 V. 15 N. 12 Dic, 2010
dc.relation.uri.none.fl_str_mv http://www.mdpi.com/1420-3049/15/12/8856
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto completo)
rights_invalid_str_mv Abierto (Texto completo)
http://purl.org/coar/access_right/c_abf2
dc.format.medium.spa.fl_str_mv Recurso electrónico
dc.format.mimetype.none.fl_str_mv application/pdf
dc.format.tipo.spa.fl_str_mv Documento
dc.publisher.spa.fl_str_mv Universidad del Rosario
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
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spelling Comunidad Rosaristada84bf35-67ee-4a8b-9fc7-af2e7f1bc0736002c1f11ba-edb4-4498-a3ef-6813708a8870600e8a0b416-2668-4440-9311-046ba68a3ff2600f3cd7e5b-e48c-40f7-a970-0399b90bb8756009e3ba9df-fe89-48fe-9521-cc8f452d56f56002014-08-12T16:59:41Z2014-08-12T16:59:41Z2010-122010Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.Recurso electrónicoapplication/pdfDocumentoISSN:1420-3049http://repository.urosario.edu.co/handle/10336/8812engUniversidad del RosarioNo. 12MOLECULESVol. 15MOLECULES ISSN: 1420-3049 V. 15 N. 12 Dic, 2010http://www.mdpi.com/1420-3049/15/12/8856Abierto (Texto completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURIncidencia & prevención de la enfermedad614600MalariaEnfermedades autoinmunesEnfermedades infecciosasInmunologíaPLASMODIUM-FALCIPARUM MALARIAMEROZOITE SURFACE PROTEIN-1SOLID-PHASE SYNTHESISMHC CLASS-IICRYSTAL-STRUCTUREAMINO-ACIDSSYNTHETIC PEPTIDESIMMUNE EVASIONBOND ANALOGRECOGNITIONDevelopment of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malariaarticleArtículohttp://purl.org/coar/resource_type/c_6501Lozano, Jose ManuelLesmes, Liliana PCarreno, LuisaGallego, Gina M.Patarroyo, Manuel E.Lozano, José ManuelLesmes, Liliana P.Carreño, Luisa F.Gallego, Gina M.Patarroyo, Manuel ElkinORIGINALmolecules-15.pdfmolecules-15.pdfapplication/pdf1153147https://repository.urosario.edu.co/bitstreams/49519f0b-f85d-4b97-adb5-abaf012d623a/download81672c5a4bd70ee3bd47b6695d148bedMD51LICENSElicense.txtlicense.txttext/plain2156https://repository.urosario.edu.co/bitstreams/b5ba716e-022b-46bd-bae1-b2f080be6890/downloadb4f8fe66e94b897ab4c355bac005ad16MD52TEXTmolecules-15.pdf.txtmolecules-15.pdf.txtExtracted 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