Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2007
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/25942
- Acceso en línea:
- https://doi.org/10.1016/j.bbrc.2007.05.015
https://repository.urosario.edu.co/handle/10336/25942
- Palabra clave:
- Malaria
Plasmodium vivax
Rhoptry
RhopH3
Vaccine candidate
- Rights
- License
- Restringido (Acceso a grupos específicos)
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EDOCUR2 |
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0d0f9c0b-6a91-4b04-9876-fd1c41582481-1fd8d3f6a-56dc-44b0-b3d0-ccd34b8d828f-100205185-8f0a-42f9-b55f-92d6b99f5c4a-170b2cbbb-5646-444b-90be-0a9c18f31ba8-1bc380284-d23e-4afd-ad07-efa220c5bd4b-179653065-12020-08-06T16:20:16Z2020-08-06T16:20:16Z2007-07-06Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins.application/pdfhttps://doi.org/10.1016/j.bbrc.2007.05.015ISSN: 0006-291XEISSN: 1090-2104https://repository.urosario.edu.co/handle/10336/25942engElsevier866No. 3861Biochemical and Biophysical Research CommunicationsVol. 358Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.358, No.3 (2007); pp.861-866https://www.sciencedirect.com/science/article/abs/pii/S0006291X07009576Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecBiochemical and Biophysical Research Communicationsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMalariaPlasmodium vivaxRhoptryRhopH3Vaccine candidateIdentifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologueIdentificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivaxarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Monguia, AlvaroPerez-Leal, OscarRojas-Caraballo, JoseAngel, Diana I.Cortes, JimenaPatarroyo, Manuel A.10336/25942oai:repository.urosario.edu.co:10336/259422022-05-02 07:37:21.733093https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
dc.title.TranslatedTitle.spa.fl_str_mv |
Identificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivax |
title |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
spellingShingle |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue Malaria Plasmodium vivax Rhoptry RhopH3 Vaccine candidate |
title_short |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
title_full |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
title_fullStr |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
title_full_unstemmed |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
title_sort |
Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue |
dc.subject.keyword.spa.fl_str_mv |
Malaria Plasmodium vivax Rhoptry RhopH3 Vaccine candidate |
topic |
Malaria Plasmodium vivax Rhoptry RhopH3 Vaccine candidate |
description |
Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. |
publishDate |
2007 |
dc.date.created.spa.fl_str_mv |
2007-07-06 |
dc.date.accessioned.none.fl_str_mv |
2020-08-06T16:20:16Z |
dc.date.available.none.fl_str_mv |
2020-08-06T16:20:16Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.bbrc.2007.05.015 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0006-291X EISSN: 1090-2104 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/25942 |
url |
https://doi.org/10.1016/j.bbrc.2007.05.015 https://repository.urosario.edu.co/handle/10336/25942 |
identifier_str_mv |
ISSN: 0006-291X EISSN: 1090-2104 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
866 |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationStartPage.none.fl_str_mv |
861 |
dc.relation.citationTitle.none.fl_str_mv |
Biochemical and Biophysical Research Communications |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 358 |
dc.relation.ispartof.spa.fl_str_mv |
Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.358, No.3 (2007); pp.861-866 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S0006291X07009576 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.source.spa.fl_str_mv |
Biochemical and Biophysical Research Communications |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167738846806016 |