Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P...

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Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/25942
Acceso en línea:
https://doi.org/10.1016/j.bbrc.2007.05.015
https://repository.urosario.edu.co/handle/10336/25942
Palabra clave:
Malaria
Plasmodium vivax
Rhoptry
RhopH3
Vaccine candidate
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License
Restringido (Acceso a grupos específicos)
id EDOCUR2_4a1f9bf04b65ebb0543c89f2a6f3fd57
oai_identifier_str oai:repository.urosario.edu.co:10336/25942
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 0d0f9c0b-6a91-4b04-9876-fd1c41582481-1fd8d3f6a-56dc-44b0-b3d0-ccd34b8d828f-100205185-8f0a-42f9-b55f-92d6b99f5c4a-170b2cbbb-5646-444b-90be-0a9c18f31ba8-1bc380284-d23e-4afd-ad07-efa220c5bd4b-179653065-12020-08-06T16:20:16Z2020-08-06T16:20:16Z2007-07-06Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins.application/pdfhttps://doi.org/10.1016/j.bbrc.2007.05.015ISSN: 0006-291XEISSN: 1090-2104https://repository.urosario.edu.co/handle/10336/25942engElsevier866No. 3861Biochemical and Biophysical Research CommunicationsVol. 358Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.358, No.3 (2007); pp.861-866https://www.sciencedirect.com/science/article/abs/pii/S0006291X07009576Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecBiochemical and Biophysical Research Communicationsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMalariaPlasmodium vivaxRhoptryRhopH3Vaccine candidateIdentifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologueIdentificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivaxarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Monguia, AlvaroPerez-Leal, OscarRojas-Caraballo, JoseAngel, Diana I.Cortes, JimenaPatarroyo, Manuel A.10336/25942oai:repository.urosario.edu.co:10336/259422022-05-02 07:37:21.733093https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
dc.title.TranslatedTitle.spa.fl_str_mv Identificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivax
title Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
spellingShingle Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
Malaria
Plasmodium vivax
Rhoptry
RhopH3
Vaccine candidate
title_short Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
title_full Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
title_fullStr Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
title_full_unstemmed Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
title_sort Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
dc.subject.keyword.spa.fl_str_mv Malaria
Plasmodium vivax
Rhoptry
RhopH3
Vaccine candidate
topic Malaria
Plasmodium vivax
Rhoptry
RhopH3
Vaccine candidate
description Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007-07-06
dc.date.accessioned.none.fl_str_mv 2020-08-06T16:20:16Z
dc.date.available.none.fl_str_mv 2020-08-06T16:20:16Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.bbrc.2007.05.015
dc.identifier.issn.none.fl_str_mv ISSN: 0006-291X
EISSN: 1090-2104
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/25942
url https://doi.org/10.1016/j.bbrc.2007.05.015
https://repository.urosario.edu.co/handle/10336/25942
identifier_str_mv ISSN: 0006-291X
EISSN: 1090-2104
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 866
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 861
dc.relation.citationTitle.none.fl_str_mv Biochemical and Biophysical Research Communications
dc.relation.citationVolume.none.fl_str_mv Vol. 358
dc.relation.ispartof.spa.fl_str_mv Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.358, No.3 (2007); pp.861-866
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0006291X07009576
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Biochemical and Biophysical Research Communications
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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