Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies

Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin Americ...

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Autores:
Tipo de recurso:
Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24220
Acceso en línea:
https://doi.org/10.1016/j.humimm.2011.03.012
https://repository.urosario.edu.co/handle/10336/24220
Palabra clave:
HLA antigen class 2
HLA DQB1 antigen
HLA DR antigen
Article
Caucasian
Diabetogenesis
Ethnicity
Gene frequency
Genetic association
Genetic risk
Haplotype
Hispanic
Human
Insulin dependent diabetes mellitus
Meta analysis
Nucleotide sequence
Priority journal
Protein function
Protein protein interaction
Alleles
Amino Acid Sequence
Computational Biology
Epitopes
Haplotypes
Histocompatibility Antigens Class II
Humans
Latin America
Peptides
Protein Binding
Autoimmunity
HLA class II
Latin America
Meta-analysis
Type 1 diabetes
Type 1
Diabetes Mellitus
Rights
License
Abierto (Texto Completo)
Description
Summary:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.