Screening for mutations of the FOXO4 gene in premature ovarian failure patients

FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22923
• Acceso en línea: https://doi.org/10.1016/j.rbmo.2011.11.017; https://repository.urosario.edu.co/handle/10336/22923
• Palabra clave: Foxo4 protein; Transcription factor; Unclassified drug; Article; Controlled study; Dna flanking region; Exon; Female; Female infertility; Gene expression; Gene mutation; Genetic screening; Genetic variability; Human; Major clinical study; Nucleotide sequence; Open reading frame; Pathogenesis; Polymerase chain reaction; Premature ovarian failure; Promoter region; Sequence analysis; Tunisia; Adult; Dna mutational analysis; Female; Gene frequency; Humans; Mutation; Open reading frames; Primary ovarian insufficiency; Transcription factors; Tunisia; Female infertility; Foxo4; Premature ovarian failure; dna; genetic; Promoter regions; Sequence analysis
• License: Abierto (Texto Completo)