Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory...

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Autores:
Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24139
Acceso en línea:
https://doi.org/10.1038/sj.gene.6364310
https://repository.urosario.edu.co/handle/10336/24139
Palabra clave:
Macrophage migration inhibition factor
Adult
Allele
Article
Clinical feature
Controlled study
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Haplotype
Human
Major clinical study
Pathogenesis
Polymerase chain reaction
Priority journal
Statistical significance
Systemic lupus erythematosus
Adult
Alleles
Case-control studies
Chromosome mapping
Confidence intervals
European continental ancestry group
Female
Gene frequency
Haplotypes
Humans
Macrophage migration-inhibitory factors
Male
Microsatellite repeats
Middle aged
Odds ratio
Promoter regions (genetics)
human
genetic
single nucleotide
systemic
pair 22
Chromosomes
Lupus erythematosus
Polymorphism
Polymorphism
Rights
License
Abierto (Texto Completo)
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spelling 46e25a54-59a8-410f-b1eb-21d59bd5453d04725674-fe3b-46b2-871e-7ef22b03c216f4f532fb-802f-42ae-a8be-15102844a00b57a638ce-5166-4e7d-aa77-b70f99d386be04ca22aa-d821-4e25-abb9-4c76a74aa0b776c0883c-396f-45d7-93a7-6d26ffec232639df6583-795e-41bc-94c3-216888149eea1947477860052671de6-8dbb-4255-9262-2cbc8afe884aada6ca12-ec25-44e5-ace4-4d651c49602d1bc1f7de-1e94-4d53-9526-b318eff1b2bb2020-05-26T00:09:07Z2020-05-26T00:09:07Z2006The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.application/pdfhttps://doi.org/10.1038/sj.gene.63643101466487914765470https://repository.urosario.edu.co/handle/10336/24139eng436No. 5433Genes and ImmunityVol. 7Genes and Immunity, ISSN:14664879, 14765470, Vol.7, No.5 (2006); pp. 433-436https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746350755&doi=10.1038%2fsj.gene.6364310&partnerID=40&md5=7dee25f208ddc56039c6d023768175edAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMacrophage migration inhibition factorAdultAlleleArticleClinical featureControlled studyGenetic associationGenetic polymorphismGenetic susceptibilityGenotypeHaplotypeHumanMajor clinical studyPathogenesisPolymerase chain reactionPriority journalStatistical significanceSystemic lupus erythematosusAdultAllelesCase-control studiesChromosome mappingConfidence intervalsEuropean continental ancestry groupFemaleGene frequencyHaplotypesHumansMacrophage migration-inhibitory factorsMaleMicrosatellite repeatsMiddle agedOdds ratioPromoter regions (genetics)humangeneticsingle nucleotidesystemicpair 22ChromosomesLupus erythematosusPolymorphismPolymorphismEvidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosusarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Sánchez E.Gómez L.M.Lopez-Nevot M.A.González-Gay M.A.Sabio J.M.Ortego-Centeno N.de Ramón E.Anaya, Juan-ManuelGonzález-Escribano M.F.Koeleman B.P.Martín J.ORIGINAL6364310.pdfapplication/pdf111927https://repository.urosario.edu.co/bitstreams/055f8437-4d75-440d-8b0d-aa4e14a9a288/download9aaece37e7ed38bc5f373dea19a46950MD51TEXT6364310.pdf.txt6364310.pdf.txtExtracted texttext/plain23018https://repository.urosario.edu.co/bitstreams/b3f532c4-0e20-4228-9dad-820f59c26b27/downloadc0daea14fba869ea3d663b2a48d728bcMD52THUMBNAIL6364310.pdf.jpg6364310.pdf.jpgGenerated Thumbnailimage/jpeg5409https://repository.urosario.edu.co/bitstreams/f452911f-a6d6-47af-98d4-70388067a24f/downloada85c7e9ba0f399aa92cba1f1a59d8e02MD5310336/24139oai:repository.urosario.edu.co:10336/241392022-05-02 07:37:13.163418https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
title Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
spellingShingle Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
Macrophage migration inhibition factor
Adult
Allele
Article
Clinical feature
Controlled study
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Haplotype
Human
Major clinical study
Pathogenesis
Polymerase chain reaction
Priority journal
Statistical significance
Systemic lupus erythematosus
Adult
Alleles
Case-control studies
Chromosome mapping
Confidence intervals
European continental ancestry group
Female
Gene frequency
Haplotypes
Humans
Macrophage migration-inhibitory factors
Male
Microsatellite repeats
Middle aged
Odds ratio
Promoter regions (genetics)
human
genetic
single nucleotide
systemic
pair 22
Chromosomes
Lupus erythematosus
Polymorphism
Polymorphism
title_short Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
title_full Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
title_fullStr Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
title_full_unstemmed Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
title_sort Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
dc.subject.keyword.spa.fl_str_mv Macrophage migration inhibition factor
Adult
Allele
Article
Clinical feature
Controlled study
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Haplotype
Human
Major clinical study
Pathogenesis
Polymerase chain reaction
Priority journal
Statistical significance
Systemic lupus erythematosus
Adult
Alleles
Case-control studies
Chromosome mapping
Confidence intervals
European continental ancestry group
Female
Gene frequency
Haplotypes
Humans
Macrophage migration-inhibitory factors
Male
Microsatellite repeats
Middle aged
Odds ratio
Promoter regions (genetics)
topic Macrophage migration inhibition factor
Adult
Allele
Article
Clinical feature
Controlled study
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Haplotype
Human
Major clinical study
Pathogenesis
Polymerase chain reaction
Priority journal
Statistical significance
Systemic lupus erythematosus
Adult
Alleles
Case-control studies
Chromosome mapping
Confidence intervals
European continental ancestry group
Female
Gene frequency
Haplotypes
Humans
Macrophage migration-inhibitory factors
Male
Microsatellite repeats
Middle aged
Odds ratio
Promoter regions (genetics)
human
genetic
single nucleotide
systemic
pair 22
Chromosomes
Lupus erythematosus
Polymorphism
Polymorphism
dc.subject.keyword.eng.fl_str_mv human
genetic
single nucleotide
systemic
pair 22
Chromosomes
Lupus erythematosus
Polymorphism
Polymorphism
description The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.
publishDate 2006
dc.date.created.spa.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:09:07Z
dc.date.available.none.fl_str_mv 2020-05-26T00:09:07Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1038/sj.gene.6364310
dc.identifier.issn.none.fl_str_mv 14664879
14765470
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24139
url https://doi.org/10.1038/sj.gene.6364310
https://repository.urosario.edu.co/handle/10336/24139
identifier_str_mv 14664879
14765470
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 436
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv 433
dc.relation.citationTitle.none.fl_str_mv Genes and Immunity
dc.relation.citationVolume.none.fl_str_mv Vol. 7
dc.relation.ispartof.spa.fl_str_mv Genes and Immunity, ISSN:14664879, 14765470, Vol.7, No.5 (2006); pp. 433-436
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746350755&doi=10.1038%2fsj.gene.6364310&partnerID=40&md5=7dee25f208ddc56039c6d023768175ed
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