Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2006
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24139
- Acceso en línea:
- https://doi.org/10.1038/sj.gene.6364310
https://repository.urosario.edu.co/handle/10336/24139
- Palabra clave:
- Macrophage migration inhibition factor
Adult
Allele
Article
Clinical feature
Controlled study
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Haplotype
Human
Major clinical study
Pathogenesis
Polymerase chain reaction
Priority journal
Statistical significance
Systemic lupus erythematosus
Adult
Alleles
Case-control studies
Chromosome mapping
Confidence intervals
European continental ancestry group
Female
Gene frequency
Haplotypes
Humans
Macrophage migration-inhibitory factors
Male
Microsatellite repeats
Middle aged
Odds ratio
Promoter regions (genetics)
human
genetic
single nucleotide
systemic
pair 22
Chromosomes
Lupus erythematosus
Polymorphism
Polymorphism
- Rights
- License
- Abierto (Texto Completo)
id |
EDOCUR2_41e2e90b608d41d5c167b861ce8ae228 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/24139 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
46e25a54-59a8-410f-b1eb-21d59bd5453d04725674-fe3b-46b2-871e-7ef22b03c216f4f532fb-802f-42ae-a8be-15102844a00b57a638ce-5166-4e7d-aa77-b70f99d386be04ca22aa-d821-4e25-abb9-4c76a74aa0b776c0883c-396f-45d7-93a7-6d26ffec232639df6583-795e-41bc-94c3-216888149eea1947477860052671de6-8dbb-4255-9262-2cbc8afe884aada6ca12-ec25-44e5-ace4-4d651c49602d1bc1f7de-1e94-4d53-9526-b318eff1b2bb2020-05-26T00:09:07Z2020-05-26T00:09:07Z2006The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.application/pdfhttps://doi.org/10.1038/sj.gene.63643101466487914765470https://repository.urosario.edu.co/handle/10336/24139eng436No. 5433Genes and ImmunityVol. 7Genes and Immunity, ISSN:14664879, 14765470, Vol.7, No.5 (2006); pp. 433-436https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746350755&doi=10.1038%2fsj.gene.6364310&partnerID=40&md5=7dee25f208ddc56039c6d023768175edAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMacrophage migration inhibition factorAdultAlleleArticleClinical featureControlled studyGenetic associationGenetic polymorphismGenetic susceptibilityGenotypeHaplotypeHumanMajor clinical studyPathogenesisPolymerase chain reactionPriority journalStatistical significanceSystemic lupus erythematosusAdultAllelesCase-control studiesChromosome mappingConfidence intervalsEuropean continental ancestry groupFemaleGene frequencyHaplotypesHumansMacrophage migration-inhibitory factorsMaleMicrosatellite repeatsMiddle agedOdds ratioPromoter regions (genetics)humangeneticsingle nucleotidesystemicpair 22ChromosomesLupus erythematosusPolymorphismPolymorphismEvidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosusarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Sánchez E.Gómez L.M.Lopez-Nevot M.A.González-Gay M.A.Sabio J.M.Ortego-Centeno N.de Ramón E.Anaya, Juan-ManuelGonzález-Escribano M.F.Koeleman B.P.Martín J.ORIGINAL6364310.pdfapplication/pdf111927https://repository.urosario.edu.co/bitstreams/055f8437-4d75-440d-8b0d-aa4e14a9a288/download9aaece37e7ed38bc5f373dea19a46950MD51TEXT6364310.pdf.txt6364310.pdf.txtExtracted texttext/plain23018https://repository.urosario.edu.co/bitstreams/b3f532c4-0e20-4228-9dad-820f59c26b27/downloadc0daea14fba869ea3d663b2a48d728bcMD52THUMBNAIL6364310.pdf.jpg6364310.pdf.jpgGenerated Thumbnailimage/jpeg5409https://repository.urosario.edu.co/bitstreams/f452911f-a6d6-47af-98d4-70388067a24f/downloada85c7e9ba0f399aa92cba1f1a59d8e02MD5310336/24139oai:repository.urosario.edu.co:10336/241392022-05-02 07:37:13.163418https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
title |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
spellingShingle |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus Macrophage migration inhibition factor Adult Allele Article Clinical feature Controlled study Genetic association Genetic polymorphism Genetic susceptibility Genotype Haplotype Human Major clinical study Pathogenesis Polymerase chain reaction Priority journal Statistical significance Systemic lupus erythematosus Adult Alleles Case-control studies Chromosome mapping Confidence intervals European continental ancestry group Female Gene frequency Haplotypes Humans Macrophage migration-inhibitory factors Male Microsatellite repeats Middle aged Odds ratio Promoter regions (genetics) human genetic single nucleotide systemic pair 22 Chromosomes Lupus erythematosus Polymorphism Polymorphism |
title_short |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
title_full |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
title_fullStr |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
title_full_unstemmed |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
title_sort |
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus |
dc.subject.keyword.spa.fl_str_mv |
Macrophage migration inhibition factor Adult Allele Article Clinical feature Controlled study Genetic association Genetic polymorphism Genetic susceptibility Genotype Haplotype Human Major clinical study Pathogenesis Polymerase chain reaction Priority journal Statistical significance Systemic lupus erythematosus Adult Alleles Case-control studies Chromosome mapping Confidence intervals European continental ancestry group Female Gene frequency Haplotypes Humans Macrophage migration-inhibitory factors Male Microsatellite repeats Middle aged Odds ratio Promoter regions (genetics) |
topic |
Macrophage migration inhibition factor Adult Allele Article Clinical feature Controlled study Genetic association Genetic polymorphism Genetic susceptibility Genotype Haplotype Human Major clinical study Pathogenesis Polymerase chain reaction Priority journal Statistical significance Systemic lupus erythematosus Adult Alleles Case-control studies Chromosome mapping Confidence intervals European continental ancestry group Female Gene frequency Haplotypes Humans Macrophage migration-inhibitory factors Male Microsatellite repeats Middle aged Odds ratio Promoter regions (genetics) human genetic single nucleotide systemic pair 22 Chromosomes Lupus erythematosus Polymorphism Polymorphism |
dc.subject.keyword.eng.fl_str_mv |
human genetic single nucleotide systemic pair 22 Chromosomes Lupus erythematosus Polymorphism Polymorphism |
description |
The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved. |
publishDate |
2006 |
dc.date.created.spa.fl_str_mv |
2006 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:09:07Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:09:07Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1038/sj.gene.6364310 |
dc.identifier.issn.none.fl_str_mv |
14664879 14765470 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24139 |
url |
https://doi.org/10.1038/sj.gene.6364310 https://repository.urosario.edu.co/handle/10336/24139 |
identifier_str_mv |
14664879 14765470 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
436 |
dc.relation.citationIssue.none.fl_str_mv |
No. 5 |
dc.relation.citationStartPage.none.fl_str_mv |
433 |
dc.relation.citationTitle.none.fl_str_mv |
Genes and Immunity |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 7 |
dc.relation.ispartof.spa.fl_str_mv |
Genes and Immunity, ISSN:14664879, 14765470, Vol.7, No.5 (2006); pp. 433-436 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746350755&doi=10.1038%2fsj.gene.6364310&partnerID=40&md5=7dee25f208ddc56039c6d023768175ed |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/055f8437-4d75-440d-8b0d-aa4e14a9a288/download https://repository.urosario.edu.co/bitstreams/b3f532c4-0e20-4228-9dad-820f59c26b27/download https://repository.urosario.edu.co/bitstreams/f452911f-a6d6-47af-98d4-70388067a24f/download |
bitstream.checksum.fl_str_mv |
9aaece37e7ed38bc5f373dea19a46950 c0daea14fba869ea3d663b2a48d728bc a85c7e9ba0f399aa92cba1f1a59d8e02 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167713072807936 |