Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis

Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of...

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Autores:
Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24217
Acceso en línea:
https://doi.org/10.1016/j.humimm.2006.07.003
https://repository.urosario.edu.co/handle/10336/24217
Palabra clave:
CD209 antigen
Adult
Allele
Article
Colombia
Controlled study
Dendritic cell
Female
Gene deletion
Gene insertion
Genetic polymorphism
Genetic predisposition
Human
Human immunodeficiency virus
Major clinical study
Male
Mycobacterium tuberculosis
Neck
Nonhuman
Nucleotide sequence
Priority journal
Promoter region
Real time polymerase chain reaction
Risk factor
Single nucleotide polymorphism
Statistical significance
Tuberculin test
Tuberculosis
Adult
Cell Adhesion Molecules
Colombia
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Tuberculosis
CD209
Colombia
DC-SIGN
Tuberculin skin test
Tuberculosis
Cell Surface
Single Nucleotide
Pulmonary
Delayed
C-Type
Hypersensitivity
Lectins
Polymorphism
Receptors
Tuberculosis
Rights
License
Abierto (Texto Completo)
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spelling 04725674-fe3b-46b2-871e-7ef22b03c216194747786006ac6f35e-7593-4892-9b72-4ec3914436335754e970-9231-4ac4-9447-ff7707f7eed220607769-e64d-4afc-b55d-c7198dda95d91bc1f7de-1e94-4d53-9526-b318eff1b2bb2020-05-26T00:10:12Z2020-05-26T00:10:12Z2006Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the 'neck' region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5? allele. The insertion/deletion in the 'neck' region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the 'neck' region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals. © 2006 American Society for Histocompatibility and Immunogenetics.application/pdfhttps://doi.org/10.1016/j.humimm.2006.07.0031988859https://repository.urosario.edu.co/handle/10336/24217eng811No. 10808Human ImmunologyVol. 67Human Immunology, ISSN:1988859, Vol.67, No.10 (2006); pp. 808-811https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750003412&doi=10.1016%2fj.humimm.2006.07.003&partnerID=40&md5=8ca82a1ec403b3a8c3d316d466f793bcAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCD209 antigenAdultAlleleArticleColombiaControlled studyDendritic cellFemaleGene deletionGene insertionGenetic polymorphismGenetic predispositionHumanHuman immunodeficiency virusMajor clinical studyMaleMycobacterium tuberculosisNeckNonhumanNucleotide sequencePriority journalPromoter regionReal time polymerase chain reactionRisk factorSingle nucleotide polymorphismStatistical significanceTuberculin testTuberculosisAdultCell Adhesion MoleculesColombiaFemaleGene FrequencyGenotypeHeterozygoteHomozygoteHumansMaleMiddle AgedTuberculosisCD209ColombiaDC-SIGNTuberculin skin testTuberculosisCell SurfaceSingle NucleotidePulmonaryDelayedC-TypeHypersensitivityLectinsPolymorphismReceptorsTuberculosisAnalysis of DC-SIGN (CD209) Functional Variants in Patients with TuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gómez L.M.Anaya, Juan-ManuelSierra-Filardi E.Cadena J.Corbí Á.Martín J.ORIGINALAnalysis_of_DC_SIGN_CD209_Functional_Var.pdfapplication/pdf93228https://repository.urosario.edu.co/bitstreams/56b5daa4-f927-42d3-9810-d0aeee4e4735/download9b6394d2664157d83edd1eefb2eba93cMD51TEXTAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.txtAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.txtExtracted texttext/plain19424https://repository.urosario.edu.co/bitstreams/abb8e071-ad7c-4149-9580-0669e19cd8e9/download2d0785ede0807bdac66db968a2594552MD52THUMBNAILAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.jpgAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.jpgGenerated Thumbnailimage/jpeg4532https://repository.urosario.edu.co/bitstreams/13b1d9b3-67e8-4c73-a0a9-19dc6d5279aa/download79d28d67cef08b6e2db8737df9d64bbeMD5310336/24217oai:repository.urosario.edu.co:10336/242172022-05-02 07:37:13.077897https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
title Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
spellingShingle Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
CD209 antigen
Adult
Allele
Article
Colombia
Controlled study
Dendritic cell
Female
Gene deletion
Gene insertion
Genetic polymorphism
Genetic predisposition
Human
Human immunodeficiency virus
Major clinical study
Male
Mycobacterium tuberculosis
Neck
Nonhuman
Nucleotide sequence
Priority journal
Promoter region
Real time polymerase chain reaction
Risk factor
Single nucleotide polymorphism
Statistical significance
Tuberculin test
Tuberculosis
Adult
Cell Adhesion Molecules
Colombia
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Tuberculosis
CD209
Colombia
DC-SIGN
Tuberculin skin test
Tuberculosis
Cell Surface
Single Nucleotide
Pulmonary
Delayed
C-Type
Hypersensitivity
Lectins
Polymorphism
Receptors
Tuberculosis
title_short Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
title_full Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
title_fullStr Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
title_full_unstemmed Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
title_sort Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
dc.subject.keyword.spa.fl_str_mv CD209 antigen
Adult
Allele
Article
Colombia
Controlled study
Dendritic cell
Female
Gene deletion
Gene insertion
Genetic polymorphism
Genetic predisposition
Human
Human immunodeficiency virus
Major clinical study
Male
Mycobacterium tuberculosis
Neck
Nonhuman
Nucleotide sequence
Priority journal
Promoter region
Real time polymerase chain reaction
Risk factor
Single nucleotide polymorphism
Statistical significance
Tuberculin test
Tuberculosis
Adult
Cell Adhesion Molecules
Colombia
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Tuberculosis
CD209
Colombia
DC-SIGN
Tuberculin skin test
Tuberculosis
topic CD209 antigen
Adult
Allele
Article
Colombia
Controlled study
Dendritic cell
Female
Gene deletion
Gene insertion
Genetic polymorphism
Genetic predisposition
Human
Human immunodeficiency virus
Major clinical study
Male
Mycobacterium tuberculosis
Neck
Nonhuman
Nucleotide sequence
Priority journal
Promoter region
Real time polymerase chain reaction
Risk factor
Single nucleotide polymorphism
Statistical significance
Tuberculin test
Tuberculosis
Adult
Cell Adhesion Molecules
Colombia
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Tuberculosis
CD209
Colombia
DC-SIGN
Tuberculin skin test
Tuberculosis
Cell Surface
Single Nucleotide
Pulmonary
Delayed
C-Type
Hypersensitivity
Lectins
Polymorphism
Receptors
Tuberculosis
dc.subject.keyword.eng.fl_str_mv Cell Surface
Single Nucleotide
Pulmonary
Delayed
C-Type
Hypersensitivity
Lectins
Polymorphism
Receptors
Tuberculosis
description Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the 'neck' region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5? allele. The insertion/deletion in the 'neck' region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the 'neck' region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals. © 2006 American Society for Histocompatibility and Immunogenetics.
publishDate 2006
dc.date.created.spa.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:10:12Z
dc.date.available.none.fl_str_mv 2020-05-26T00:10:12Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.humimm.2006.07.003
dc.identifier.issn.none.fl_str_mv 1988859
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24217
url https://doi.org/10.1016/j.humimm.2006.07.003
https://repository.urosario.edu.co/handle/10336/24217
identifier_str_mv 1988859
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 811
dc.relation.citationIssue.none.fl_str_mv No. 10
dc.relation.citationStartPage.none.fl_str_mv 808
dc.relation.citationTitle.none.fl_str_mv Human Immunology
dc.relation.citationVolume.none.fl_str_mv Vol. 67
dc.relation.ispartof.spa.fl_str_mv Human Immunology, ISSN:1988859, Vol.67, No.10 (2006); pp. 808-811
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750003412&doi=10.1016%2fj.humimm.2006.07.003&partnerID=40&md5=8ca82a1ec403b3a8c3d316d466f793bc
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