Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2006
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24217
- Acceso en línea:
- https://doi.org/10.1016/j.humimm.2006.07.003
https://repository.urosario.edu.co/handle/10336/24217
- Palabra clave:
- CD209 antigen
Adult
Allele
Article
Colombia
Controlled study
Dendritic cell
Female
Gene deletion
Gene insertion
Genetic polymorphism
Genetic predisposition
Human
Human immunodeficiency virus
Major clinical study
Male
Mycobacterium tuberculosis
Neck
Nonhuman
Nucleotide sequence
Priority journal
Promoter region
Real time polymerase chain reaction
Risk factor
Single nucleotide polymorphism
Statistical significance
Tuberculin test
Tuberculosis
Adult
Cell Adhesion Molecules
Colombia
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Tuberculosis
CD209
Colombia
DC-SIGN
Tuberculin skin test
Tuberculosis
Cell Surface
Single Nucleotide
Pulmonary
Delayed
C-Type
Hypersensitivity
Lectins
Polymorphism
Receptors
Tuberculosis
- Rights
- License
- Abierto (Texto Completo)
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04725674-fe3b-46b2-871e-7ef22b03c216194747786006ac6f35e-7593-4892-9b72-4ec3914436335754e970-9231-4ac4-9447-ff7707f7eed220607769-e64d-4afc-b55d-c7198dda95d91bc1f7de-1e94-4d53-9526-b318eff1b2bb2020-05-26T00:10:12Z2020-05-26T00:10:12Z2006Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the 'neck' region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5? allele. The insertion/deletion in the 'neck' region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the 'neck' region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals. © 2006 American Society for Histocompatibility and Immunogenetics.application/pdfhttps://doi.org/10.1016/j.humimm.2006.07.0031988859https://repository.urosario.edu.co/handle/10336/24217eng811No. 10808Human ImmunologyVol. 67Human Immunology, ISSN:1988859, Vol.67, No.10 (2006); pp. 808-811https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750003412&doi=10.1016%2fj.humimm.2006.07.003&partnerID=40&md5=8ca82a1ec403b3a8c3d316d466f793bcAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCD209 antigenAdultAlleleArticleColombiaControlled studyDendritic cellFemaleGene deletionGene insertionGenetic polymorphismGenetic predispositionHumanHuman immunodeficiency virusMajor clinical studyMaleMycobacterium tuberculosisNeckNonhumanNucleotide sequencePriority journalPromoter regionReal time polymerase chain reactionRisk factorSingle nucleotide polymorphismStatistical significanceTuberculin testTuberculosisAdultCell Adhesion MoleculesColombiaFemaleGene FrequencyGenotypeHeterozygoteHomozygoteHumansMaleMiddle AgedTuberculosisCD209ColombiaDC-SIGNTuberculin skin testTuberculosisCell SurfaceSingle NucleotidePulmonaryDelayedC-TypeHypersensitivityLectinsPolymorphismReceptorsTuberculosisAnalysis of DC-SIGN (CD209) Functional Variants in Patients with TuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gómez L.M.Anaya, Juan-ManuelSierra-Filardi E.Cadena J.Corbí Á.Martín J.ORIGINALAnalysis_of_DC_SIGN_CD209_Functional_Var.pdfapplication/pdf93228https://repository.urosario.edu.co/bitstreams/56b5daa4-f927-42d3-9810-d0aeee4e4735/download9b6394d2664157d83edd1eefb2eba93cMD51TEXTAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.txtAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.txtExtracted texttext/plain19424https://repository.urosario.edu.co/bitstreams/abb8e071-ad7c-4149-9580-0669e19cd8e9/download2d0785ede0807bdac66db968a2594552MD52THUMBNAILAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.jpgAnalysis_of_DC_SIGN_CD209_Functional_Var.pdf.jpgGenerated Thumbnailimage/jpeg4532https://repository.urosario.edu.co/bitstreams/13b1d9b3-67e8-4c73-a0a9-19dc6d5279aa/download79d28d67cef08b6e2db8737df9d64bbeMD5310336/24217oai:repository.urosario.edu.co:10336/242172022-05-02 07:37:13.077897https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
title |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
spellingShingle |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis CD209 antigen Adult Allele Article Colombia Controlled study Dendritic cell Female Gene deletion Gene insertion Genetic polymorphism Genetic predisposition Human Human immunodeficiency virus Major clinical study Male Mycobacterium tuberculosis Neck Nonhuman Nucleotide sequence Priority journal Promoter region Real time polymerase chain reaction Risk factor Single nucleotide polymorphism Statistical significance Tuberculin test Tuberculosis Adult Cell Adhesion Molecules Colombia Female Gene Frequency Genotype Heterozygote Homozygote Humans Male Middle Aged Tuberculosis CD209 Colombia DC-SIGN Tuberculin skin test Tuberculosis Cell Surface Single Nucleotide Pulmonary Delayed C-Type Hypersensitivity Lectins Polymorphism Receptors Tuberculosis |
title_short |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
title_full |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
title_fullStr |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
title_full_unstemmed |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
title_sort |
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis |
dc.subject.keyword.spa.fl_str_mv |
CD209 antigen Adult Allele Article Colombia Controlled study Dendritic cell Female Gene deletion Gene insertion Genetic polymorphism Genetic predisposition Human Human immunodeficiency virus Major clinical study Male Mycobacterium tuberculosis Neck Nonhuman Nucleotide sequence Priority journal Promoter region Real time polymerase chain reaction Risk factor Single nucleotide polymorphism Statistical significance Tuberculin test Tuberculosis Adult Cell Adhesion Molecules Colombia Female Gene Frequency Genotype Heterozygote Homozygote Humans Male Middle Aged Tuberculosis CD209 Colombia DC-SIGN Tuberculin skin test Tuberculosis |
topic |
CD209 antigen Adult Allele Article Colombia Controlled study Dendritic cell Female Gene deletion Gene insertion Genetic polymorphism Genetic predisposition Human Human immunodeficiency virus Major clinical study Male Mycobacterium tuberculosis Neck Nonhuman Nucleotide sequence Priority journal Promoter region Real time polymerase chain reaction Risk factor Single nucleotide polymorphism Statistical significance Tuberculin test Tuberculosis Adult Cell Adhesion Molecules Colombia Female Gene Frequency Genotype Heterozygote Homozygote Humans Male Middle Aged Tuberculosis CD209 Colombia DC-SIGN Tuberculin skin test Tuberculosis Cell Surface Single Nucleotide Pulmonary Delayed C-Type Hypersensitivity Lectins Polymorphism Receptors Tuberculosis |
dc.subject.keyword.eng.fl_str_mv |
Cell Surface Single Nucleotide Pulmonary Delayed C-Type Hypersensitivity Lectins Polymorphism Receptors Tuberculosis |
description |
Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the 'neck' region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5? allele. The insertion/deletion in the 'neck' region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the 'neck' region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals. © 2006 American Society for Histocompatibility and Immunogenetics. |
publishDate |
2006 |
dc.date.created.spa.fl_str_mv |
2006 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:10:12Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:10:12Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.humimm.2006.07.003 |
dc.identifier.issn.none.fl_str_mv |
1988859 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24217 |
url |
https://doi.org/10.1016/j.humimm.2006.07.003 https://repository.urosario.edu.co/handle/10336/24217 |
identifier_str_mv |
1988859 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
811 |
dc.relation.citationIssue.none.fl_str_mv |
No. 10 |
dc.relation.citationStartPage.none.fl_str_mv |
808 |
dc.relation.citationTitle.none.fl_str_mv |
Human Immunology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 67 |
dc.relation.ispartof.spa.fl_str_mv |
Human Immunology, ISSN:1988859, Vol.67, No.10 (2006); pp. 808-811 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750003412&doi=10.1016%2fj.humimm.2006.07.003&partnerID=40&md5=8ca82a1ec403b3a8c3d316d466f793bc |
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