Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)

Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus. © 2017 Blackwell Verlag GmbH

• Fecha de publicación: 2017
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22634
• Acceso en línea: https://doi.org/10.1111/myc.12601; https://repository.urosario.edu.co/handle/10336/22634
• Palabra clave: 60S ribosomal protein; Beta tubulin; Elongation factor 3; Fungal DNA; Fungal protein; Genomic DNA; Unclassified drug; Ajellomyces dermatitidis; Ajellomycetaceae; Article; Blastomyces; Blastomyces gilchristii; Blastomyces percursus; Cell budding; Comparative study; Controlled study; DNA extraction; Emergomyces africanus; Emergomyces orientalis; Emergomyces pasteurianus; Emmonsia; Emmonsia crescens; Emmonsia parva; Emmonsia pasteuriana; Fungal genome; Fungal strain; Molecular genetics; Morphological trait; New species; Nonhuman; North America; Nucleotide sequence; Onygenales; Phylogenomics; Phylogeny; Priority journal; Sequence alignment; South Africa; Whole genome sequencing; Blastomyces; Chrysosporium; Classification; DNA sequence; Fungal genome; Fungus spore; Genetics; Histoplasma; Human; Microbiology; Microscopy; Mycelium; Mycoses; Onygenales; Pathogenicity; Phenotype; Ultrastructure; Blastomyces; Chrysosporium; Histoplasma; Humans; Microscopy; Mycelium; Mycoses; North America; Onygenales; Phenotype; Phylogeny; South Africa; Ajellomycetaceae; Blastomyces; Emergomyces; Emmonsia; Genomics; Phylogeny; Fungal; Fungal; DNA; Genome; Sequence Analysis; Spores
• License: Abierto (Texto Completo)