Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model

Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides th...

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Fecha de publicación:: 2006

Institución:: Universidad del Rosario

Repositorio:: Repositorio EdocUR - U. Rosario

Idioma:: eng

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network_acronym_str	EDOCUR2
network_name_str	Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
title	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
spellingShingle	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines animal surface secondary protozoan protozoan inbred c3h Antibodies Antigens Antigens Immunization Mice Toxoplasmosis
title_short	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
title_full	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
title_fullStr	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
title_full_unstemmed	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
title_sort	Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
dc.subject.keyword.spa.fl_str_mv	Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines
topic	Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine Isoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucine Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid Membrane protein Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline Peptide derivative Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine Protein sag1 Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline Unclassified drug Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline Animal experiment Animal model Article Carboxy terminal sequence Controlled study Immunogenicity Male Mouse Nonhuman Nucleotide sequence Priority journal Survival Toxoplasma gondii Toxoplasmosis Vaccination Amino acid sequence Animals Male Mice Molecular sequence data Peptides Protozoan proteins Protozoan vaccines Toxoplasma Murinae Toxoplasma Toxoplasma gondii Murine model P30 Peptides Sag1 Toxoplasma gondii Vaccines animal surface secondary protozoan protozoan inbred c3h Antibodies Antigens Antigens Immunization Mice Toxoplasmosis
dc.subject.keyword.eng.fl_str_mv	animal surface secondary protozoan protozoan inbred c3h Antibodies Antigens Antigens Immunization Mice Toxoplasmosis
description	Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved.
publishDate	2006
dc.date.created.spa.fl_str_mv	2006
dc.date.accessioned.none.fl_str_mv	2020-05-26T00:07:52Z
dc.date.available.none.fl_str_mv	2020-05-26T00:07:52Z
dc.type.eng.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv	Artículo
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1016/j.exppara.2006.02.005
dc.identifier.issn.none.fl_str_mv	00144894 10902449
dc.identifier.uri.none.fl_str_mv	https://repository.urosario.edu.co/handle/10336/24037
url	https://doi.org/10.1016/j.exppara.2006.02.005 https://repository.urosario.edu.co/handle/10336/24037
identifier_str_mv	00144894 10902449
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.relation.citationEndPage.none.fl_str_mv	65
dc.relation.citationIssue.none.fl_str_mv	No. 1
dc.relation.citationStartPage.none.fl_str_mv	62
dc.relation.citationTitle.none.fl_str_mv	Experimental Parasitology
dc.relation.citationVolume.none.fl_str_mv	Vol. 114
dc.relation.ispartof.spa.fl_str_mv	Experimental Parasitology, ISSN:00144894, 10902449, Vol.114, No.1 (2006); pp. 62-65
dc.relation.uri.spa.fl_str_mv	https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746905060&doi=10.1016%2fj.exppara.2006.02.005&partnerID=40&md5=3e0b22c255906acdcaa51e6295815d14
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv	Abierto (Texto Completo)
rights_invalid_str_mv	Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv	application/pdf
institution	Universidad del Rosario
dc.source.instname.spa.fl_str_mv	instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv	reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv	Repositorio institucional EdocUR
repository.mail.fl_str_mv	edocur@urosario.edu.co
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spelling	55ba803e-3d54-45e9-92b3-bfb362dc0294-1ed6b7ee0-074e-4311-8f72-05373100084e-1ee523b37-b267-434c-9e98-1f4189442505-176e03223-040d-4e46-864f-3bdecc8d2790-132bd6bb6-c8df-4306-a307-875aa892e2f5-12020-05-26T00:07:52Z2020-05-26T00:07:52Z2006Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved.application/pdfhttps://doi.org/10.1016/j.exppara.2006.02.0050014489410902449https://repository.urosario.edu.co/handle/10336/24037eng65No. 162Experimental ParasitologyVol. 114Experimental Parasitology, ISSN:00144894, 10902449, Vol.114, No.1 (2006); pp. 62-65https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746905060&doi=10.1016%2fj.exppara.2006.02.005&partnerID=40&md5=3e0b22c255906acdcaa51e6295815d14Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanineIsoleucylcysteinylprolylalanylglycylthreonylthreonylserylserylcysteinyl threonylseryllysylalanylvalylthreonylleucylserylserylleucineIsoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycineIsoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycineLeucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteineLysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanineLysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamineLysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serineLysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acidMembrane proteinMethionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl prolinePeptide derivativePhenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucinePhenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanineProlylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucineProtein sag1Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserineSerylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylprolineUnclassified drugValylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acidValyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvalineAnimal experimentAnimal modelArticleCarboxy terminal sequenceControlled studyImmunogenicityMaleMouseNonhumanNucleotide sequencePriority journalSurvivalToxoplasma gondiiToxoplasmosisVaccinationAmino acid sequenceAnimalsMaleMiceMolecular sequence dataPeptidesProtozoan proteinsProtozoan vaccinesToxoplasmaMurinaeToxoplasmaToxoplasma gondiiMurine modelP30PeptidesSag1Toxoplasma gondiiVaccinesanimalsurfacesecondaryprotozoanprotozoaninbred c3hAntibodiesAntigensAntigensImmunizationMiceToxoplasmosisToxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine modelarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Siachoque H.Guzman F.Burgos J.Patarroyo M.E.Gomez Marin J.E.10336/24037oai:repository.urosario.edu.co:10336/240372022-05-02 07:37:21.36202https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co

Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model

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