Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas

Introducción: El trasplante de células madre hematopoyéticas (SCHT) se utiliza para reestablecer la función hematopoyética en pacientes con alteración o daño en la médula ósea; en pediatría se realiza el 20% del total de estos procedimientos. La reconstitución inmunológica y el recuento plaquetario...

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Fecha de publicación:
2020
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/25181
Acceso en línea:
https://doi.org/10.48713/10336_25181
https://repository.urosario.edu.co/handle/10336/25181
Palabra clave:
Trasplante de progenitores hematopoyéticos PH
Trasplante alogénico
Niños
Trombocitopenia
Pronóstico
Sobrevida
Enfermedad injerto contra huésped EICH
Enfermedades
Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Prognosis
Survival Analysis
Graft vs Host Disease
Transplantation
Homologous
Rights
License
Atribución-NoComercial-SinDerivadas 2.5 Colombia
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oai_identifier_str oai:repository.urosario.edu.co:10336/25181
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
dc.title.TranslatedTitle.eng.fl_str_mv Relationship between platelet and lymphocyte count and survival in patients under 18 years of age with allogeneic hematopoietic stem cell transplantation
title Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
spellingShingle Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
Trasplante de progenitores hematopoyéticos PH
Trasplante alogénico
Niños
Trombocitopenia
Pronóstico
Sobrevida
Enfermedad injerto contra huésped EICH
Enfermedades
Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Prognosis
Survival Analysis
Graft vs Host Disease
Transplantation
Homologous
title_short Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
title_full Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
title_fullStr Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
title_full_unstemmed Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
title_sort Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas
dc.contributor.advisor.none.fl_str_mv Aponte Barrios, Nelson Hernando
dc.subject.spa.fl_str_mv Trasplante de progenitores hematopoyéticos PH
Trasplante alogénico
Niños
Trombocitopenia
Pronóstico
Sobrevida
Enfermedad injerto contra huésped EICH
topic Trasplante de progenitores hematopoyéticos PH
Trasplante alogénico
Niños
Trombocitopenia
Pronóstico
Sobrevida
Enfermedad injerto contra huésped EICH
Enfermedades
Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Prognosis
Survival Analysis
Graft vs Host Disease
Transplantation
Homologous
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.keyword.spa.fl_str_mv Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Prognosis
Survival Analysis
Graft vs Host Disease
dc.subject.keyword.eng.fl_str_mv Transplantation
Homologous
description Introducción: El trasplante de células madre hematopoyéticas (SCHT) se utiliza para reestablecer la función hematopoyética en pacientes con alteración o daño en la médula ósea; en pediatría se realiza el 20% del total de estos procedimientos. La reconstitución inmunológica y el recuento plaquetario posterior al trasplante se relaciona con mejor o peor pronóstico, recaída de la enfermedad y la sobrevida. Objetivos: Evaluar la asociación entre el conteo plaquetario y linfocitario, la supervivencia general y libre de evento en una unidad de trasplantes pediátrica con trasplante alogénico por enfermedades hematooncológicas e inmunodeficiencia Metodología: Estudio analítico observacional de cohorte retrospectiva, se incluyeron 124 pacientes menores de 18 años a quien se les realizó trasplante alogénico de células madre hematopoyéticas entre 2010 a 2016 en el Hospital Pediátrico de la Misericordia, los pacientes que sobrevivieron sin recaída al día 100 se les cuantificó conteo de plaquetas y linfocitos y se siguieron hasta 3 años. Resultados: La probabilidad de supervivencia en pacientes con linfocitos <1000 al año fue de 75,36% (IC 95% 64,51-88,03%), a los dos años fue de 58,6% (IC 95% 46,45-74,08%) y a los tres años fue de 52,21% (IC 95% 39,9-68,2%) vs de 85,4% (IC 95% 77-94,7%) de 77% (IC 95% 67,1-88,4%) de 71,9% (IC 95% 61,4-84,2%) para el grupo con >1000 linfocitos respectivamente (Log-Rank=0,037). La media de supervivencia para los pacientes con plaquetas <100.000 fue de 35.2 meses (+/-3.17) y para quienes tuvieron plaquetas >100.000 fue de 39,3 meses (+/- 2.19) p=0.19. La trombocitopenia tiene se relacion con desarrollo de IECH aguda p=0,001. Discusión: El conteo absoluto de linfocitos al día 100 post trasplante es un factor independiente que afecta directamente la sobrevida de los pacientes.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-06-16T18:45:33Z
dc.date.available.none.fl_str_mv 2020-06-16T18:45:33Z
dc.date.created.none.fl_str_mv 2020-06-12
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.spa.fl_str_mv Descriptivo observacional retrospectivo
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_25181
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/25181
url https://doi.org/10.48713/10336_25181
https://repository.urosario.edu.co/handle/10336/25181
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de medicina
institution Universidad del Rosario
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spelling Aponte Barrios, Nelson Hernandod291a40f-d74f-429c-8e9e-b54915971a11600Chavarriaga Ruíz, NatalyEstupiñan Calvache, MarcelaVallejo Rosero, CristianCastañeda Figueroa, Ana MariaEspecialista en Epidemiología (en Convenio con el CES)Full timeee37358b-7adc-4087-9e24-b194e4a92713600526b708c-f44b-4637-b0fc-21ed1837afa56003f691318-7680-4c5b-ae64-75755571276d600d986ab7e-26bd-4291-b463-2c3bdfc992356002020-06-16T18:45:33Z2020-06-16T18:45:33Z2020-06-12Introducción: El trasplante de células madre hematopoyéticas (SCHT) se utiliza para reestablecer la función hematopoyética en pacientes con alteración o daño en la médula ósea; en pediatría se realiza el 20% del total de estos procedimientos. La reconstitución inmunológica y el recuento plaquetario posterior al trasplante se relaciona con mejor o peor pronóstico, recaída de la enfermedad y la sobrevida. Objetivos: Evaluar la asociación entre el conteo plaquetario y linfocitario, la supervivencia general y libre de evento en una unidad de trasplantes pediátrica con trasplante alogénico por enfermedades hematooncológicas e inmunodeficiencia Metodología: Estudio analítico observacional de cohorte retrospectiva, se incluyeron 124 pacientes menores de 18 años a quien se les realizó trasplante alogénico de células madre hematopoyéticas entre 2010 a 2016 en el Hospital Pediátrico de la Misericordia, los pacientes que sobrevivieron sin recaída al día 100 se les cuantificó conteo de plaquetas y linfocitos y se siguieron hasta 3 años. Resultados: La probabilidad de supervivencia en pacientes con linfocitos <1000 al año fue de 75,36% (IC 95% 64,51-88,03%), a los dos años fue de 58,6% (IC 95% 46,45-74,08%) y a los tres años fue de 52,21% (IC 95% 39,9-68,2%) vs de 85,4% (IC 95% 77-94,7%) de 77% (IC 95% 67,1-88,4%) de 71,9% (IC 95% 61,4-84,2%) para el grupo con >1000 linfocitos respectivamente (Log-Rank=0,037). La media de supervivencia para los pacientes con plaquetas <100.000 fue de 35.2 meses (+/-3.17) y para quienes tuvieron plaquetas >100.000 fue de 39,3 meses (+/- 2.19) p=0.19. La trombocitopenia tiene se relacion con desarrollo de IECH aguda p=0,001. Discusión: El conteo absoluto de linfocitos al día 100 post trasplante es un factor independiente que afecta directamente la sobrevida de los pacientes.Introduction: Hematopoietic stem cell transplantation (SCHT) is used to reestablish hematopoietic function in patients with impaired or damaged bone marrow. In pediatrics 20% of these procedures are performed. Both immune reconstitution and post-transplant platelet count have been shown to be associated with better or worse prognosis, disease relapse, and overall survival. Objective: To assess the association between platelet and lymphocyte count, overall survival, and event-free survival in a pediatric transplant unit with allogeneic transplantation for haemato-oncological diseases and immunodeficiency. Materials and methods: Retrospective observational analytical cohort study, 124 patients under 18 years of age who underwent allogeneic hematopoietic stem cell transplantation between 2010 and 2016 at the Pediatric Hospital of La Misericordia were included; patients who survived without relapse on day 100 were quantified platelet and lymphocyte count and followed up to 3 years. Results: The probability of survival in patients with lymphocytes <1000 a year was 75.36% (95% CI 64.51-88.03%), after two years it was 58.6% (95% CI 46, 45-74.08%) and at three years it was 52.21% (95% CI 39.9-68.2%) vs 85.4% (95% CI 77-94.7%) 77% (95% CI 67.1-88.4%) of 71.9% (95% CI 61.4-84.2%) for the group with> 1000 lymphocytes respectively (Log-Rank = 0.037). The mean survival for patients with platelets <100,000 was 35.2 months (+/- 3.17) and for those with platelets> 100,000 it was 39.3 months (+/- 2.19) p = 0.19. Thrombocytopenia is related to development of acute IECH p = 0.001. Conclusion: The absolute lymphocyte count at day 100 post transplant is an independent factor that directly affects the survival of patients.2020-06-16 13:50:01: Script de automatizacion de embargos. Correo recibido: Cristian Vallejo <cristian_gv@hotmail.com> Vie 12/06/2020 5:55 PM Cordial Saludo. Por medio de este medio solicito el embargo por un periodo de dos años del trabajo de grado “ Relación entre el conteo plaquetario y linfocitario y la sobreviva en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas” que se presentó para optar el titulo de especialista en epidemiología. La razón es que que al ser un trabajo original será mandado a una revistar para su publicación. Gracias. Quedo atento a la solicitud. - Respuesta: Repositorio Institucional EdocUR Mar 16/06/2020 1:48 PM Respetado Cristian Vallejo, reciba un cordial saludo, Hemos realizado la publicación de su documento "Relación entre el conteo plaquetario y linfocitario y la sobrevida en pacientes menores de 18 años con trasplante alogénico de células madre hematopoyéticas", el cual puede consultar en el siguiente enlace: https://repository.urosario.edu.co/handle/10336/25181 De acuerdo con su solicitud, el documento ha quedado embargado hasta el 2022-06-16 en concordancia con las Políticas de Acceso Abierto de la Universidad. Si usted desea dejarlo con acceso abierto antes de finalizar dicho periodo o si por el contrario desea extender el embargo al finalizar este tiempo, puede enviar un correo a esta misma dirección realizando la solicitud. Tenga en cuenta que los documentos en acceso abierto propician una mayor visibilidad de su producción académica. Quedamos atentos a cualquier inquietud o sugerencia2022-06-16 01:01:02: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2022-06-15application/pdfhttps://doi.org/10.48713/10336_25181 https://repository.urosario.edu.co/handle/10336/25181spaUniversidad del RosarioFacultad de medicinaAtribución-NoComercial-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. 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