Rheumatoid arthritis in African Colombians from Quibdo

Objectives: Little data is available on the prevalence and incidence of rheumatoid arthritis (RA) or the genetic and environmental factors that influence RA risk and severity in non-Caucasian populations. The prevalence of RA in Caucasians and some Native American populations is 1% or more; in contr...

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Autores:
Tipo de recurso:
Fecha de publicación:
2001
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26905
Acceso en línea:
https://doi.org/10.1053/sarh.2001.27737
https://repository.urosario.edu.co/handle/10336/26905
Palabra clave:
Rheumatoid arthritis
African Colombians
HLA-DRB1
HLA-DQB1
Rheumatoid factor
Antikeratin antibodies
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_3a2067a02abc7f793acf2be967d614ef
oai_identifier_str oai:repository.urosario.edu.co:10336/26905
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 19474778600db6634cb-78db-456d-82d5-fa7140510037ab7e3e14-43e1-4674-adc9-dca2487fd9b6b731917e-ec60-4b54-9ee4-e5c1a52bc1bd444776ec-2c2c-4e9a-b960-70d54e75a21e860c0d92-d7ea-4157-8842-c6690f0ec7982020-08-19T14:40:30Z2020-08-19T14:40:30Z2001-12Objectives: Little data is available on the prevalence and incidence of rheumatoid arthritis (RA) or the genetic and environmental factors that influence RA risk and severity in non-Caucasian populations. The prevalence of RA in Caucasians and some Native American populations is 1% or more; in contrast, low prevalences of RA have been reported in some African populations. We determined the hospital incidence (HI) and period prevalence (PP) of RA in African Colombians in Quibdo, Colombia, by using data collected at the Hospital San Francisco de Asis, a primary-to-tertiary care center. Genetic and immunologic studies of factors that influence RA risk and severity, such as HLA genes, immunoglobulin-A (IgA) rheumatoid factor (RF), and antikeratin antibodies (AKA) were performed. African Colombians with RA also were compared with Mestizo RA patients from Medellín, Colombia. Methods: To determine the HI, all the outpatient charts for 1995 were reviewed (n = 3,044). PP during 1996 (Jan-Dec) was assessed by stratified sampling of all African Colombians aged 18 or more having arthralgia. Participants completed a survey and a pretested standard questionnaire, had hands and feet X-rays, and provided a blood sample. Total and IgA RF were measured by turbidimetry and ELISA, respectively; AKA were assessed by indirect immunofluorescence on rat esophagus. HLA-DRB1 and DQB1 alleles were determined by polymerase chain reaction technique with primers of specific sequence and by reverse dot blot. Results: The HI was 0.65 cases per 1,000 person years. There were 321 individuals with arthralgia (0.3%; 95% CI, 0.28-0.3), 18 of whom fulfilled the American College of Rheumatology criteria for RA (PP in the general population, 0.01%; 95% CI, 0.008-0.02). Lower erosion scores were seen in African Colombian patients compared to Mestizos (n = 56), although duration of disease was similar in each group. No association between any HLA allele and RA risk or RA severity or between autoantibodies and RA severity was observed in African Colombians. Comparisons showed no significant differences between African Colombians and Mestizo patients in the presence of RF (total and IgA), AKA, age at onset, extra-articular manifestations, formal education level, and history of malaria. Conclusions: These results suggest that RA in African Colombian patients from Quibdo is rare, may be less severe in terms of radiographic damage than in Colombian Mestizo patients, and lacks association to HLA-DRB1 and DQB1 alleles. Additionally, RF (total and IgA) and AKA are not markers of progression and activity of the disease in this population.application/pdfhttps://doi.org/10.1053/sarh.2001.27737ISSN: 0049-0172EISSN: 1532-866Xhttps://repository.urosario.edu.co/handle/10336/26905engW.B. SaundersElsevier198No. 3191Seminars in Arthritis and RheumatismVol. 31Seminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol.31, No.3 (December 2001); pp. 191-198https://www.sciencedirect.com/science/article/abs/pii/S0049017201334777?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecSeminars in Arthritis and Rheumatisminstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURRheumatoid arthritisAfrican ColombiansHLA-DRB1HLA-DQB1Rheumatoid factorAntikeratin antibodiesRheumatoid arthritis in African Colombians from QuibdoArtritis reumatoide en afrocolombianos de QuibdóarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelCorrea, Paula A.Mantilla, Rubén D.Jimenez, FabioKuffner, TamaraMcNicholl, Janet M.10336/26905oai:repository.urosario.edu.co:10336/269052022-05-02 07:37:13.766944https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Rheumatoid arthritis in African Colombians from Quibdo
dc.title.TranslatedTitle.spa.fl_str_mv Artritis reumatoide en afrocolombianos de Quibdó
title Rheumatoid arthritis in African Colombians from Quibdo
spellingShingle Rheumatoid arthritis in African Colombians from Quibdo
Rheumatoid arthritis
African Colombians
HLA-DRB1
HLA-DQB1
Rheumatoid factor
Antikeratin antibodies
title_short Rheumatoid arthritis in African Colombians from Quibdo
title_full Rheumatoid arthritis in African Colombians from Quibdo
title_fullStr Rheumatoid arthritis in African Colombians from Quibdo
title_full_unstemmed Rheumatoid arthritis in African Colombians from Quibdo
title_sort Rheumatoid arthritis in African Colombians from Quibdo
dc.subject.keyword.spa.fl_str_mv Rheumatoid arthritis
African Colombians
HLA-DRB1
HLA-DQB1
Rheumatoid factor
Antikeratin antibodies
topic Rheumatoid arthritis
African Colombians
HLA-DRB1
HLA-DQB1
Rheumatoid factor
Antikeratin antibodies
description Objectives: Little data is available on the prevalence and incidence of rheumatoid arthritis (RA) or the genetic and environmental factors that influence RA risk and severity in non-Caucasian populations. The prevalence of RA in Caucasians and some Native American populations is 1% or more; in contrast, low prevalences of RA have been reported in some African populations. We determined the hospital incidence (HI) and period prevalence (PP) of RA in African Colombians in Quibdo, Colombia, by using data collected at the Hospital San Francisco de Asis, a primary-to-tertiary care center. Genetic and immunologic studies of factors that influence RA risk and severity, such as HLA genes, immunoglobulin-A (IgA) rheumatoid factor (RF), and antikeratin antibodies (AKA) were performed. African Colombians with RA also were compared with Mestizo RA patients from Medellín, Colombia. Methods: To determine the HI, all the outpatient charts for 1995 were reviewed (n = 3,044). PP during 1996 (Jan-Dec) was assessed by stratified sampling of all African Colombians aged 18 or more having arthralgia. Participants completed a survey and a pretested standard questionnaire, had hands and feet X-rays, and provided a blood sample. Total and IgA RF were measured by turbidimetry and ELISA, respectively; AKA were assessed by indirect immunofluorescence on rat esophagus. HLA-DRB1 and DQB1 alleles were determined by polymerase chain reaction technique with primers of specific sequence and by reverse dot blot. Results: The HI was 0.65 cases per 1,000 person years. There were 321 individuals with arthralgia (0.3%; 95% CI, 0.28-0.3), 18 of whom fulfilled the American College of Rheumatology criteria for RA (PP in the general population, 0.01%; 95% CI, 0.008-0.02). Lower erosion scores were seen in African Colombian patients compared to Mestizos (n = 56), although duration of disease was similar in each group. No association between any HLA allele and RA risk or RA severity or between autoantibodies and RA severity was observed in African Colombians. Comparisons showed no significant differences between African Colombians and Mestizo patients in the presence of RF (total and IgA), AKA, age at onset, extra-articular manifestations, formal education level, and history of malaria. Conclusions: These results suggest that RA in African Colombian patients from Quibdo is rare, may be less severe in terms of radiographic damage than in Colombian Mestizo patients, and lacks association to HLA-DRB1 and DQB1 alleles. Additionally, RF (total and IgA) and AKA are not markers of progression and activity of the disease in this population.
publishDate 2001
dc.date.created.spa.fl_str_mv 2001-12
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:30Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:30Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1053/sarh.2001.27737
dc.identifier.issn.none.fl_str_mv ISSN: 0049-0172
EISSN: 1532-866X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26905
url https://doi.org/10.1053/sarh.2001.27737
https://repository.urosario.edu.co/handle/10336/26905
identifier_str_mv ISSN: 0049-0172
EISSN: 1532-866X
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 198
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 191
dc.relation.citationTitle.none.fl_str_mv Seminars in Arthritis and Rheumatism
dc.relation.citationVolume.none.fl_str_mv Vol. 31
dc.relation.ispartof.spa.fl_str_mv Seminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol.31, No.3 (December 2001); pp. 191-198
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0049017201334777?via%3Dihub
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv W.B. Saunders
Elsevier
dc.source.spa.fl_str_mv Seminars in Arthritis and Rheumatism
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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