Narcolepsy, Infections, and Autoimmunity
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In par...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24291
- Acceso en línea:
- https://doi.org/10.1016/B978-0-444-63269-2.00064-7
https://repository.urosario.edu.co/handle/10336/24291
- Palabra clave:
- Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
- Rights
- License
- Abierto (Texto Completo)
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3b0a0171-7a9a-42f7-9109-3d1be6eff9ad-1abf6d844-0cd0-41c4-b93d-0d7323499104-1751e2509-f1ab-4892-a16a-b8c59144709b-1b6ececbc-d25e-4c58-a7d9-a058a1533d39-10dcf3458-407c-4249-b7d9-9317eff7255e-1ef6fa7cf-59f5-4c86-bc53-d389160d7ddf-12020-05-26T00:11:15Z2020-05-26T00:11:15Z2015Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved.application/pdfhttps://doi.org/10.1016/B978-0-444-63269-2.00064-7https://repository.urosario.edu.co/handle/10336/24291engElsevier Inc.10141003Infection and AutoimmunityInfection and Autoimmunity,(2015); pp. 1003-1014https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072148355&doi=10.1016%2fB978-0-444-63269-2.00064-7&partnerID=40&md5=2788703111483ee13bf19b7148707168Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAutoimmunityH1N1H1N1 vaccineNarcolepsyStreptococcus spp.Narcolepsy, Infections, and AutoimmunitybookPartParte de librohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_3248Arango, María-TeresaKivity, ShayeAgmon-Levin, NancyChapman, JoabGivaty, GiliShoenfeld, Yehuda10336/24291oai:repository.urosario.edu.co:10336/242912022-05-02 07:37:18.949777https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Narcolepsy, Infections, and Autoimmunity |
title |
Narcolepsy, Infections, and Autoimmunity |
spellingShingle |
Narcolepsy, Infections, and Autoimmunity Autoimmunity H1N1 H1N1 vaccine Narcolepsy Streptococcus spp. |
title_short |
Narcolepsy, Infections, and Autoimmunity |
title_full |
Narcolepsy, Infections, and Autoimmunity |
title_fullStr |
Narcolepsy, Infections, and Autoimmunity |
title_full_unstemmed |
Narcolepsy, Infections, and Autoimmunity |
title_sort |
Narcolepsy, Infections, and Autoimmunity |
dc.subject.keyword.spa.fl_str_mv |
Autoimmunity H1N1 H1N1 vaccine Narcolepsy Streptococcus spp. |
topic |
Autoimmunity H1N1 H1N1 vaccine Narcolepsy Streptococcus spp. |
description |
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved. |
publishDate |
2015 |
dc.date.created.spa.fl_str_mv |
2015 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:11:15Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:11:15Z |
dc.type.eng.fl_str_mv |
bookPart |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_3248 |
dc.type.spa.spa.fl_str_mv |
Parte de libro |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/B978-0-444-63269-2.00064-7 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24291 |
url |
https://doi.org/10.1016/B978-0-444-63269-2.00064-7 https://repository.urosario.edu.co/handle/10336/24291 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
1014 |
dc.relation.citationStartPage.none.fl_str_mv |
1003 |
dc.relation.citationTitle.none.fl_str_mv |
Infection and Autoimmunity |
dc.relation.ispartof.spa.fl_str_mv |
Infection and Autoimmunity,(2015); pp. 1003-1014 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072148355&doi=10.1016%2fB978-0-444-63269-2.00064-7&partnerID=40&md5=2788703111483ee13bf19b7148707168 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier Inc. |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167552961544192 |