Narcolepsy, Infections, and Autoimmunity

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In par...

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Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24291
Acceso en línea:
https://doi.org/10.1016/B978-0-444-63269-2.00064-7
https://repository.urosario.edu.co/handle/10336/24291
Palabra clave:
Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
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License
Abierto (Texto Completo)
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network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 3b0a0171-7a9a-42f7-9109-3d1be6eff9ad-1abf6d844-0cd0-41c4-b93d-0d7323499104-1751e2509-f1ab-4892-a16a-b8c59144709b-1b6ececbc-d25e-4c58-a7d9-a058a1533d39-10dcf3458-407c-4249-b7d9-9317eff7255e-1ef6fa7cf-59f5-4c86-bc53-d389160d7ddf-12020-05-26T00:11:15Z2020-05-26T00:11:15Z2015Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved.application/pdfhttps://doi.org/10.1016/B978-0-444-63269-2.00064-7https://repository.urosario.edu.co/handle/10336/24291engElsevier Inc.10141003Infection and AutoimmunityInfection and Autoimmunity,(2015); pp. 1003-1014https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072148355&doi=10.1016%2fB978-0-444-63269-2.00064-7&partnerID=40&md5=2788703111483ee13bf19b7148707168Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAutoimmunityH1N1H1N1 vaccineNarcolepsyStreptococcus spp.Narcolepsy, Infections, and AutoimmunitybookPartParte de librohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_3248Arango, María-TeresaKivity, ShayeAgmon-Levin, NancyChapman, JoabGivaty, GiliShoenfeld, Yehuda10336/24291oai:repository.urosario.edu.co:10336/242912022-05-02 07:37:18.949777https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Narcolepsy, Infections, and Autoimmunity
title Narcolepsy, Infections, and Autoimmunity
spellingShingle Narcolepsy, Infections, and Autoimmunity
Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
title_short Narcolepsy, Infections, and Autoimmunity
title_full Narcolepsy, Infections, and Autoimmunity
title_fullStr Narcolepsy, Infections, and Autoimmunity
title_full_unstemmed Narcolepsy, Infections, and Autoimmunity
title_sort Narcolepsy, Infections, and Autoimmunity
dc.subject.keyword.spa.fl_str_mv Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
topic Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
description Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved.
publishDate 2015
dc.date.created.spa.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:15Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:15Z
dc.type.eng.fl_str_mv bookPart
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_3248
dc.type.spa.spa.fl_str_mv Parte de libro
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/B978-0-444-63269-2.00064-7
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24291
url https://doi.org/10.1016/B978-0-444-63269-2.00064-7
https://repository.urosario.edu.co/handle/10336/24291
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1014
dc.relation.citationStartPage.none.fl_str_mv 1003
dc.relation.citationTitle.none.fl_str_mv Infection and Autoimmunity
dc.relation.ispartof.spa.fl_str_mv Infection and Autoimmunity,(2015); pp. 1003-1014
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072148355&doi=10.1016%2fB978-0-444-63269-2.00064-7&partnerID=40&md5=2788703111483ee13bf19b7148707168
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier Inc.
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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