alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.

Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps an...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26236
Acceso en línea:
https://doi.org/10.1034/j.1399-0039.2003.00045.x
https://repository.urosario.edu.co/handle/10336/26236
Palabra clave:
Animal models
Aotus
Evolution
MHC class I
PBR
Platyrrhini
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_2c7711ec36ecbd0f610d69fa04f6a14b
oai_identifier_str oai:repository.urosario.edu.co:10336/26236
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 20b87ac9-637e-491a-88a8-542cfcd798d2-169cb2876-47aa-4b7f-86b0-d7b7870e2501-172e8587f-0a67-48fe-bb5b-6c087d23b93e-10f6d3532-9127-4b2d-95eb-347a048be3d3-152726e17-8674-4169-8d7a-bd5072ed2434-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-12020-08-06T16:21:03Z2020-08-06T16:21:03Z2013-05-12Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini’s classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.application/pdfhttps://doi.org/10.1034/j.1399-0039.2003.00045.xEISSN: 2059-2310https://repository.urosario.edu.co/handle/10336/26236engThe HLA AwardJohn Wiley & Sons373No. 5362HLA. Tissue AntigensVol. 61HLA.Tissue Antigens, EISSN:2059-2310, Vol.61, No.5 (May, 2003) pp 362-373https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1399-0039.2003.00045.xRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecHLA. Tissue Antigensinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAnimal modelsAotusEvolutionMHC class IPBRPlatyrrhinialpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.Los dominios alpha1 y alpha2 de Aotus MHC Clase I y Catarrhini MHC Clase Ia comparten características similares.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Suárez, C. F.Cárdenas, P. P.Llanos-Ballestas, E. J.Mart?ínez, P.Obregon, M.Patarroyo, M. A.10336/26236oai:repository.urosario.edu.co:10336/262362021-06-03 00:50:29.054https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
dc.title.TranslatedTitle.spa.fl_str_mv Los dominios alpha1 y alpha2 de Aotus MHC Clase I y Catarrhini MHC Clase Ia comparten características similares.
title alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
spellingShingle alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
Animal models
Aotus
Evolution
MHC class I
PBR
Platyrrhini
title_short alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
title_full alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
title_fullStr alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
title_full_unstemmed alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
title_sort alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
dc.subject.keyword.spa.fl_str_mv Animal models
Aotus
Evolution
MHC class I
PBR
Platyrrhini
topic Animal models
Aotus
Evolution
MHC class I
PBR
Platyrrhini
description Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini’s classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.
publishDate 2013
dc.date.created.spa.fl_str_mv 2013-05-12
dc.date.accessioned.none.fl_str_mv 2020-08-06T16:21:03Z
dc.date.available.none.fl_str_mv 2020-08-06T16:21:03Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1034/j.1399-0039.2003.00045.x
dc.identifier.issn.none.fl_str_mv EISSN: 2059-2310
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26236
url https://doi.org/10.1034/j.1399-0039.2003.00045.x
https://repository.urosario.edu.co/handle/10336/26236
identifier_str_mv EISSN: 2059-2310
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 373
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv 362
dc.relation.citationTitle.none.fl_str_mv HLA. Tissue Antigens
dc.relation.citationVolume.none.fl_str_mv Vol. 61
dc.relation.ispartof.spa.fl_str_mv HLA.Tissue Antigens, EISSN:2059-2310, Vol.61, No.5 (May, 2003) pp 362-373
dc.relation.uri.spa.fl_str_mv https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1399-0039.2003.00045.x
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv The HLA Award
John Wiley & Sons
dc.source.spa.fl_str_mv HLA. Tissue Antigens
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1808390755787472896

Publicaciones similares