Rheumatoid pericarditis: New immunopathological aspects

Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a...

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Fecha de publicación:
1994
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26907
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/26907
Palabra clave:
Rheumatoid pericarditis
Immunohistologic
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id EDOCUR2_29983d176dcf209a1b77f663ff051fad
oai_identifier_str oai:repository.urosario.edu.co:10336/26907
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 1947477860055070b93-177f-4fd3-ab9e-a373dd7966d5e8938956-af14-46bd-9749-62565a90def14bf4320b-b239-4bcd-9149-1cdfc34606422020-08-19T14:40:30Z2020-08-19T14:40:30Z1994Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a complete immunohistological study of two RA patients with RP complications, using a panel of monoclonal antibodies (mAbs) for the recognition of B, T, and NK cells. Both cases showed strong and almost exclusive pericardial membrane infiltration of CD8+ T-cells which was correlated with a higher than expected similar increase in the subset of peripheral blood lymphocytes (PBL). These findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.application/pdfISSN: 0392-856XEISSN: 1593-098Xhttps://repository.urosario.edu.co/handle/10336/26907engEurope PMC316No. 3313Clinical and Experimental RheumatologyVol. 12Clinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X, Vol.12, No.3 (1994);pp. 313-316https://europepmc.org/article/med/8070167Bloqueado (Texto referencial)http://purl.org/coar/access_right/c_14cbClinical and Experimental Rheumatologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURRheumatoid pericarditisImmunohistologicRheumatoid pericarditis: New immunopathological aspectsPericarditis reumatoide: nuevos aspectos inmunopatológicosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelEncinoza, TravaglioSAny, J.Réme T.10336/26907oai:repository.urosario.edu.co:10336/269072021-08-10 17:08:39.789https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Rheumatoid pericarditis: New immunopathological aspects
dc.title.TranslatedTitle.spa.fl_str_mv Pericarditis reumatoide: nuevos aspectos inmunopatológicos
title Rheumatoid pericarditis: New immunopathological aspects
spellingShingle Rheumatoid pericarditis: New immunopathological aspects
Rheumatoid pericarditis
Immunohistologic
title_short Rheumatoid pericarditis: New immunopathological aspects
title_full Rheumatoid pericarditis: New immunopathological aspects
title_fullStr Rheumatoid pericarditis: New immunopathological aspects
title_full_unstemmed Rheumatoid pericarditis: New immunopathological aspects
title_sort Rheumatoid pericarditis: New immunopathological aspects
dc.subject.keyword.spa.fl_str_mv Rheumatoid pericarditis
Immunohistologic
topic Rheumatoid pericarditis
Immunohistologic
description Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a complete immunohistological study of two RA patients with RP complications, using a panel of monoclonal antibodies (mAbs) for the recognition of B, T, and NK cells. Both cases showed strong and almost exclusive pericardial membrane infiltration of CD8+ T-cells which was correlated with a higher than expected similar increase in the subset of peripheral blood lymphocytes (PBL). These findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.
publishDate 1994
dc.date.created.spa.fl_str_mv 1994
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:30Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:30Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN: 0392-856X
EISSN: 1593-098X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26907
identifier_str_mv ISSN: 0392-856X
EISSN: 1593-098X
url https://repository.urosario.edu.co/handle/10336/26907
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 316
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 313
dc.relation.citationTitle.none.fl_str_mv Clinical and Experimental Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 12
dc.relation.ispartof.spa.fl_str_mv Clinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X, Vol.12, No.3 (1994);pp. 313-316
dc.relation.uri.spa.fl_str_mv https://europepmc.org/article/med/8070167
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.acceso.spa.fl_str_mv Bloqueado (Texto referencial)
rights_invalid_str_mv Bloqueado (Texto referencial)
http://purl.org/coar/access_right/c_14cb
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Europe PMC
dc.source.spa.fl_str_mv Clinical and Experimental Rheumatology
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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