The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic pe...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2007
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27043
- Acceso en línea:
- https://doi.org/10.1016/j.vaccine.2006.12.041
https://repository.urosario.edu.co/handle/10336/27043
- Palabra clave:
- Plasmodium vivax
Reticulocyte binding protein
Immune response
Aotus monkeys
- Rights
- License
- Restringido (Acceso a grupos específicos)
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EDOCUR2 |
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Repositorio EdocUR - U. Rosario |
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00205185-8f0a-42f9-b55f-92d6b99f5c4a-1efcdd5ad-3279-498e-aa37-f283c1e8305f-1faaf745c-61cf-4170-a36f-07c6154b327c-179653065-12020-08-19T14:40:50Z2020-08-19T14:40:50Z2007-05-04Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic peptides spanning the entire PvRBP1 sequence have shown that 25 out of the 195 peptides synthesised (grouped into 4 different regions) displayed high affinity binding to reticulocytes. The PvRBP1 region III (amino acids 1998–2348), encompassing 9 of the previously described high-affinity reticulocyte binding peptides, was expressed as a recombinant protein in the present study. This protein has been shown to be antigenic in humans and it has also been able to induce good humoral and cellular immune responses in Aotus nancymaae monkeys. Despite its high immunogenicity, no protective efficacy was observed in the immunised animals.application/pdfhttps://doi.org/10.1016/j.vaccine.2006.12.041ISSN: 0264-410XEISSN: 1873-2518https://repository.urosario.edu.co/handle/10336/27043engThe Japanese Society for VaccinologyElsevier3721No. 183713VaccineVol. 25Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.25, No.18 (2007); pp. 3713-3721 https://www.sciencedirect.com/science/article/pii/S0264410X06013685Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecVaccineinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPlasmodium vivaxReticulocyte binding proteinImmune responseAotus monkeysThe antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeysLa antigenicidad de un fragmento recombinante de la proteína de unión a reticulocitos 1 de Plasmodium vivax (PvRBP1) en humanos y sus estudios de inmunogenicidad y protección en monos aotusarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas Caraballo, JoseDelgado, GabrielaRodriguez, RaulPatarroyo, Manuel A.10336/27043oai:repository.urosario.edu.co:10336/270432021-06-03 00:50:04.688https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
dc.title.TranslatedTitle.spa.fl_str_mv |
La antigenicidad de un fragmento recombinante de la proteína de unión a reticulocitos 1 de Plasmodium vivax (PvRBP1) en humanos y sus estudios de inmunogenicidad y protección en monos aotus |
title |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
spellingShingle |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys Plasmodium vivax Reticulocyte binding protein Immune response Aotus monkeys |
title_short |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
title_full |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
title_fullStr |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
title_full_unstemmed |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
title_sort |
The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys |
dc.subject.keyword.spa.fl_str_mv |
Plasmodium vivax Reticulocyte binding protein Immune response Aotus monkeys |
topic |
Plasmodium vivax Reticulocyte binding protein Immune response Aotus monkeys |
description |
Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic peptides spanning the entire PvRBP1 sequence have shown that 25 out of the 195 peptides synthesised (grouped into 4 different regions) displayed high affinity binding to reticulocytes. The PvRBP1 region III (amino acids 1998–2348), encompassing 9 of the previously described high-affinity reticulocyte binding peptides, was expressed as a recombinant protein in the present study. This protein has been shown to be antigenic in humans and it has also been able to induce good humoral and cellular immune responses in Aotus nancymaae monkeys. Despite its high immunogenicity, no protective efficacy was observed in the immunised animals. |
publishDate |
2007 |
dc.date.created.spa.fl_str_mv |
2007-05-04 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:40:50Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:40:50Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.vaccine.2006.12.041 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0264-410X EISSN: 1873-2518 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27043 |
url |
https://doi.org/10.1016/j.vaccine.2006.12.041 https://repository.urosario.edu.co/handle/10336/27043 |
identifier_str_mv |
ISSN: 0264-410X EISSN: 1873-2518 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
3721 |
dc.relation.citationIssue.none.fl_str_mv |
No. 18 |
dc.relation.citationStartPage.none.fl_str_mv |
3713 |
dc.relation.citationTitle.none.fl_str_mv |
Vaccine |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 25 |
dc.relation.ispartof.spa.fl_str_mv |
Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.25, No.18 (2007); pp. 3713-3721 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S0264410X06013685 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
The Japanese Society for Vaccinology Elsevier |
dc.source.spa.fl_str_mv |
Vaccine |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167429013569536 |