The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys

Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic pe...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27043
Acceso en línea:
https://doi.org/10.1016/j.vaccine.2006.12.041
https://repository.urosario.edu.co/handle/10336/27043
Palabra clave:
Plasmodium vivax
Reticulocyte binding protein
Immune response
Aotus monkeys
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_268a8e42eaeb1ad885e7b6db94eb7a2a
oai_identifier_str oai:repository.urosario.edu.co:10336/27043
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 00205185-8f0a-42f9-b55f-92d6b99f5c4a-1efcdd5ad-3279-498e-aa37-f283c1e8305f-1faaf745c-61cf-4170-a36f-07c6154b327c-179653065-12020-08-19T14:40:50Z2020-08-19T14:40:50Z2007-05-04Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic peptides spanning the entire PvRBP1 sequence have shown that 25 out of the 195 peptides synthesised (grouped into 4 different regions) displayed high affinity binding to reticulocytes. The PvRBP1 region III (amino acids 1998–2348), encompassing 9 of the previously described high-affinity reticulocyte binding peptides, was expressed as a recombinant protein in the present study. This protein has been shown to be antigenic in humans and it has also been able to induce good humoral and cellular immune responses in Aotus nancymaae monkeys. Despite its high immunogenicity, no protective efficacy was observed in the immunised animals.application/pdfhttps://doi.org/10.1016/j.vaccine.2006.12.041ISSN: 0264-410XEISSN: 1873-2518https://repository.urosario.edu.co/handle/10336/27043engThe Japanese Society for VaccinologyElsevier3721No. 183713VaccineVol. 25Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.25, No.18 (2007); pp. 3713-3721 https://www.sciencedirect.com/science/article/pii/S0264410X06013685Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecVaccineinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPlasmodium vivaxReticulocyte binding proteinImmune responseAotus monkeysThe antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeysLa antigenicidad de un fragmento recombinante de la proteína de unión a reticulocitos 1 de Plasmodium vivax (PvRBP1) en humanos y sus estudios de inmunogenicidad y protección en monos aotusarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas Caraballo, JoseDelgado, GabrielaRodriguez, RaulPatarroyo, Manuel A.10336/27043oai:repository.urosario.edu.co:10336/270432021-06-03 00:50:04.688https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
dc.title.TranslatedTitle.spa.fl_str_mv La antigenicidad de un fragmento recombinante de la proteína de unión a reticulocitos 1 de Plasmodium vivax (PvRBP1) en humanos y sus estudios de inmunogenicidad y protección en monos aotus
title The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
spellingShingle The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
Plasmodium vivax
Reticulocyte binding protein
Immune response
Aotus monkeys
title_short The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
title_full The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
title_fullStr The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
title_full_unstemmed The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
title_sort The antigenicity of a plasmodium vivax reticulocyte binding protein-1 (PvRBP1) recombinant fragment in humans and its immunogenicity and protection studies in aotus monkeys
dc.subject.keyword.spa.fl_str_mv Plasmodium vivax
Reticulocyte binding protein
Immune response
Aotus monkeys
topic Plasmodium vivax
Reticulocyte binding protein
Immune response
Aotus monkeys
description Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic peptides spanning the entire PvRBP1 sequence have shown that 25 out of the 195 peptides synthesised (grouped into 4 different regions) displayed high affinity binding to reticulocytes. The PvRBP1 region III (amino acids 1998–2348), encompassing 9 of the previously described high-affinity reticulocyte binding peptides, was expressed as a recombinant protein in the present study. This protein has been shown to be antigenic in humans and it has also been able to induce good humoral and cellular immune responses in Aotus nancymaae monkeys. Despite its high immunogenicity, no protective efficacy was observed in the immunised animals.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007-05-04
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:50Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:50Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.vaccine.2006.12.041
dc.identifier.issn.none.fl_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27043
url https://doi.org/10.1016/j.vaccine.2006.12.041
https://repository.urosario.edu.co/handle/10336/27043
identifier_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 3721
dc.relation.citationIssue.none.fl_str_mv No. 18
dc.relation.citationStartPage.none.fl_str_mv 3713
dc.relation.citationTitle.none.fl_str_mv Vaccine
dc.relation.citationVolume.none.fl_str_mv Vol. 25
dc.relation.ispartof.spa.fl_str_mv Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.25, No.18 (2007); pp. 3713-3721
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0264410X06013685
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv The Japanese Society for Vaccinology
Elsevier
dc.source.spa.fl_str_mv Vaccine
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167429013569536