Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática

Introducción: Las vacunas clásicamente han representado un método económico y eficaz para el control y prevención de múltiples enfermedades infecciosas. En los últimos años se han introducido nuevas vacunas contra neumococo a precios elevados, y los diferentes análisis económicos a nivel mundial de...

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Tipo de recurso:
Fecha de publicación:
2014
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/9026
Acceso en línea:
https://doi.org/10.48713/10336_9026
http://repository.urosario.edu.co/handle/10336/9026
Palabra clave:
vacunas conjugadas
Neumococo
Farmacoeconomia
Incidencia & prevención de la enfermedad
Vacuna cuadrivalente
Epidemiología
bacterias estreptocócicas
pharmacoeconomics
pneumococcus
Conjugate vaccines
Rights
License
Abierto (Texto completo)
id EDOCUR2_217d0cf76413ed704adeffe3d0be5fff
oai_identifier_str oai:repository.urosario.edu.co:10336/9026
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
title Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
spellingShingle Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
vacunas conjugadas
Neumococo
Farmacoeconomia
Incidencia & prevención de la enfermedad
Vacuna cuadrivalente
Epidemiología
bacterias estreptocócicas
pharmacoeconomics
pneumococcus
Conjugate vaccines
title_short Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
title_full Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
title_fullStr Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
title_full_unstemmed Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
title_sort Análisis económico de las vacunas 10-valente y 13-valente contra neumococo: revisión sistemática
dc.contributor.advisor.none.fl_str_mv Rojas-Villarraga, Adriana
dc.subject.spa.fl_str_mv vacunas conjugadas
Neumococo
Farmacoeconomia
topic vacunas conjugadas
Neumococo
Farmacoeconomia
Incidencia & prevención de la enfermedad
Vacuna cuadrivalente
Epidemiología
bacterias estreptocócicas
pharmacoeconomics
pneumococcus
Conjugate vaccines
dc.subject.ddc.none.fl_str_mv Incidencia & prevención de la enfermedad
dc.subject.decs.spa.fl_str_mv Vacuna cuadrivalente
Epidemiología
bacterias estreptocócicas
dc.subject.keyword.eng.fl_str_mv pharmacoeconomics
pneumococcus
Conjugate vaccines
description Introducción: Las vacunas clásicamente han representado un método económico y eficaz para el control y prevención de múltiples enfermedades infecciosas. En los últimos años se han introducido nuevas vacunas contra neumococo a precios elevados, y los diferentes análisis económicos a nivel mundial de estas vacunas no muestran tendencias. El objetivo de este trabajo era resumir la evidencia existente a través de los diferentes estudios económicos evaluando las dos vacunas de segunda generación contra neumococo en la población a riesgo. Metodología: En este trabajo se realizo una revisión sistemática de la literatura en 8 bases de datos localizadas en diferentes partes del mundo y también que tuvieran literatura gris. Los artículos fueron inicialmente evaluados acorde a su titulo y resumen, posteriormente los elegidos se analizaron en su totalidad. Resultados: Se encontraron 404 artículos, de los cuales 20 fueron incluidos en el análisis final. Se encontró que la mayoría de los estudios se realizaron en áreas donde la enfermedad tiene una carga baja, como es Norte América y Europa, mientras que en los lugares del mundo donde la carga es mas alta, se realizaron pocos estudios. De igual manera se observo que la mayoría de los estudios mostraron por los menos ser costo efectivos respecto a la no vacunación, y en su totalidad las dos vacunas de segunda generación mostraron costo efectividad respecto a la vacunación con PCV-7. Los resultados de los estudios son muy heterogéneos, hasta dentro del mismo país, señalando la necesidad de guías para la conducción de este tipo de estudios. De igual manera, la mayoría de los estudios fueron financiados por farmacéuticas, mientras en un numero muy reducido por entes gubernamentales. Conclusiones: La mayoría de los estudios económicos sobre las vacunas de segunda generación contra neumococo han sido realizados en países con un alto índice de desarrollo económico y patrocinados por farmacéuticas. Dado que la mayoría de la carga de la enfermedad se encuentran en regiones con un menor nivel de desarrollo económico se deberían realizar mas en estas zonas. De igual manera, al ser la vacunación un asunto de salud publica y con un importante impacto económico los gobiernos deberían estar mas involucrados en los mismos.
publishDate 2014
dc.date.accessioned.none.fl_str_mv 2014-11-18T13:18:04Z
dc.date.available.none.fl_str_mv 2014-11-18T13:18:04Z
dc.date.created.none.fl_str_mv 2014-08-01
dc.date.issued.none.fl_str_mv 2014
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_9026
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/9026
url https://doi.org/10.48713/10336_9026
http://repository.urosario.edu.co/handle/10336/9026
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto completo)
dc.rights.cc.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Atribución-NoComercial-SinDerivadas 2.5 Colombia
rights_invalid_str_mv Abierto (Texto completo)
Atribución-NoComercial-SinDerivadas 2.5 Colombia
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de medicina
institution Universidad del Rosario
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spelling Rojas-Villarraga, Adriana52249701600Torres Garrido, Alba LuzVargas-Zambrano, Juan-CamiloEspecialista en Epidemiología (en Convenio con el CES)0997e73e-da45-4e21-b2ab-a5f332d6b853-165e9bd59-0de4-4119-876e-78afbfaa6f44-12014-11-18T13:18:04Z2014-11-18T13:18:04Z2014-08-012014Introducción: Las vacunas clásicamente han representado un método económico y eficaz para el control y prevención de múltiples enfermedades infecciosas. En los últimos años se han introducido nuevas vacunas contra neumococo a precios elevados, y los diferentes análisis económicos a nivel mundial de estas vacunas no muestran tendencias. El objetivo de este trabajo era resumir la evidencia existente a través de los diferentes estudios económicos evaluando las dos vacunas de segunda generación contra neumococo en la población a riesgo. Metodología: En este trabajo se realizo una revisión sistemática de la literatura en 8 bases de datos localizadas en diferentes partes del mundo y también que tuvieran literatura gris. Los artículos fueron inicialmente evaluados acorde a su titulo y resumen, posteriormente los elegidos se analizaron en su totalidad. Resultados: Se encontraron 404 artículos, de los cuales 20 fueron incluidos en el análisis final. Se encontró que la mayoría de los estudios se realizaron en áreas donde la enfermedad tiene una carga baja, como es Norte América y Europa, mientras que en los lugares del mundo donde la carga es mas alta, se realizaron pocos estudios. De igual manera se observo que la mayoría de los estudios mostraron por los menos ser costo efectivos respecto a la no vacunación, y en su totalidad las dos vacunas de segunda generación mostraron costo efectividad respecto a la vacunación con PCV-7. Los resultados de los estudios son muy heterogéneos, hasta dentro del mismo país, señalando la necesidad de guías para la conducción de este tipo de estudios. De igual manera, la mayoría de los estudios fueron financiados por farmacéuticas, mientras en un numero muy reducido por entes gubernamentales. Conclusiones: La mayoría de los estudios económicos sobre las vacunas de segunda generación contra neumococo han sido realizados en países con un alto índice de desarrollo económico y patrocinados por farmacéuticas. Dado que la mayoría de la carga de la enfermedad se encuentran en regiones con un menor nivel de desarrollo económico se deberían realizar mas en estas zonas. De igual manera, al ser la vacunación un asunto de salud publica y con un importante impacto económico los gobiernos deberían estar mas involucrados en los mismos.Introduction: An easy and effective method for control and prevention of multiple infectious diseases has been massive vaccination. Lately, two new conjugate vaccines against pneumococcus appeared at high prices, and economical analysis do not show a tendency towards the use of this vaccine. The objective of this work was to collect and analyze available information regarding economical evaluations of second-generation pneumococcal conjugate vaccines in risk population. Methodology: Information was systematically gathered through a systematic review of the literature. Eight different databases, located in different countries, and some containing grey literature were used to look for the articles. Initially articles were assessed according to their title and abstract. Afterwards, selected articles were completely read and analyzed for final inclusion. Results: This work was systematic review, in which 404 articles were found and 20 were included in the final analysis. It was found that most of the studies were done in North America and Europe, while countries with the highest burden of the disease (Africa and South East Asia), only few studies were done. Moreover, it was seen that most of the studies showed that the two new vaccines were at least cost effective respect to the use of PCV-7. The results were very heterogeneous, and even in the same country. This shows the need of guidelines for this type of studies. Finally, most of the studies were sponsor by pharmaceutical companies, while just a reduced number were by governmental funds. Conclusions: The vast majority of studies were done in countries with a high index of development and sponsored by pharmaceutical companies. Due to the fact that the burden of pneumococcal infection is located in other regions, associated with countries with a lower development index, more studies are needed in these locations. Likewise, as this is a public health issue, governments should be more strongly involved, conducting and publishing their own economical analyses. application/pdfhttps://doi.org/10.48713/10336_9026 http://repository.urosario.edu.co/handle/10336/9026spaUniversidad del RosarioFacultad de medicinaAbierto (Texto completo)Atribución-NoComercial-SinDerivadas 2.5 ColombiaAtribución-NoComercial-SinDerivadas 2.5 ColombiaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://purl.org/coar/access_right/c_abf2Klimek J, Cavallito C, Bailey J. 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http://www.scopus.com/inward/record.url?eid=2-s2.0-80051811740&partnerID=40&md5=0c9fe22140ac889b3b2456ec4da06e5c.Vespa, G, D O Constenla, C Pepe, M A Safadi, E Berezin, J C de Moraes, C A de Campos, D V Araujo, and A L de Andrade. 2009. “Estimating the Cost-Effectiveness of Pneumococcal Conjugate Vaccination in Brazil.” Rev Panam Salud Publica 26(6): 518–28.De Wals, Philippe, Steven Black, Ray Borrow, and David Pearce. 2009. “Modeling the Impact of a New Vaccine on Pneumococcal and Nontypable Haemophilus Influenzae Diseases: A New Simulation Model.” Clinical therapeutics 31(10): 2152–69. http://www.ncbi.nlm.nih.gov/pubmed/19922887 (January 27, 2014).Wu, David Bin-Chia, Chee-Jen Chang, Yu-Chering Huang, Yu-Wen Wen, Chia-Ling Wu, and Cathy Shen-Jang Fann. 2012. “Cost-Effectiveness Analysis of Pneumococcal Conjugate Vaccine in Taiwan: A Transmission Dynamic Modeling Approach.” Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 15(1 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