Polyautoimmunity and familial autoimmunity in systemic sclerosis

Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune dis...

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Autores:
Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22248
Acceso en línea:
https://doi.org/10.1016/j.jaut.2008.05.002
https://repository.urosario.edu.co/handle/10336/22248
Palabra clave:
Adult
Article
Autoimmunity
Controlled study
Family history
Female
Human
Immunity
Major clinical study
Male
Phenotype
Primary biliary cirrhosis
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Systemic sclerosis
Thyroid disease
Autoimmunity
Canada
Colombia
Female
Genetic predisposition to disease
Humans
Male
Middle aged
Prevalence
Autoimmune thyroid disease
Familial autoimmunity
Rheumatoid arthritis
Sjögren's syndrome
Systemic sclerosis
systemic
Scleroderma
Rights
License
Abierto (Texto Completo)
Description
Summary:Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38%) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38%), rheumatoid arthritis (RA, 21%), Sjögren's syndrome (18%), and primary biliary cirrhosis (4%). There were 260 (36%) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18%) and AITD (9%). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. © 2008 Elsevier Ltd. All rights reserved.