Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence

As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells....

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Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26945
Acceso en línea:
https://doi.org/10.2174/157340608784325160
https://repository.urosario.edu.co/handle/10336/26945
Palabra clave:
Malaria
P. falciparum
1H-NMR
HLA-DR?1* molecules
Immunogenic peptides
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License
Restringido (Acceso a grupos específicos)
id EDOCUR2_209e1d86489837956bdcabb2f9cbee12
oai_identifier_str oai:repository.urosario.edu.co:10336/26945
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 561fb322-adc5-402b-aba7-327f7564e559-1945960d6-2fe1-44f7-8364-43269b57c123-135e93ecb-65a2-41f4-8ee0-ec18e35368f6-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-176e03223-040d-4e46-864f-3bdecc8d2790-12020-08-19T14:40:35Z2020-08-19T14:40:35Z2008-05As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells. Hundreds of experiments in large numbers of Aotus monkeys revealed that this immunological code of silence could be broken by shifting the polarity of some critical host cell binding residues in these HABPs by substituting F for R and vice versa, YW, LH, IN, PD, MK or E, CT, VN or S; there are special rules for A, G and S. 1H-nuclear magnetic resonance of these modified, immunogenic, protection-inducing HABPs and molecular modelling revealed that such modifications induced appropriate fitting into specific HLA-DR?1* Pockets, suggesting the presence of new pockets and a haplotype- and allele-specific conscious TCR. A highly immunogenic and protection-inducing anti-malarial vaccine can thus be produced.application/pdfhttps://doi.org/10.2174/157340608784325160ISSN: 1573-4064EISSN: 1875-6638https://repository.urosario.edu.co/handle/10336/26945engBentham Science Publishers292No. 3278Medicinal ChemistryVol. 4Medicinal Chemistry, ISSN: 1573-4064;EISSN: 1875-6638, Vol.4, No.3 (2008); pp. 278-292 https://www.eurekaselect.com/82668/articleRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecMedicinal Chemistryinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMalariaP. falciparum1H-NMRHLA-DR?1* moleculesImmunogenic peptidesShifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silenceCambiar la polaridad de algunos residuos críticos en la unión de los péptidos de la malaria a las células huésped es un factor clave para romper el código de silencio de los antígenos conservadosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cifuentes, G.Bermudez, A.Rodriguez, R.Patarroyo, M. A.Patarroyo, M. E.10336/26945oai:repository.urosario.edu.co:10336/269452022-05-02 07:37:13.454897https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
dc.title.TranslatedTitle.spa.fl_str_mv Cambiar la polaridad de algunos residuos críticos en la unión de los péptidos de la malaria a las células huésped es un factor clave para romper el código de silencio de los antígenos conservados
title Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
spellingShingle Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
Malaria
P. falciparum
1H-NMR
HLA-DR?1* molecules
Immunogenic peptides
title_short Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
title_full Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
title_fullStr Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
title_full_unstemmed Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
title_sort Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
dc.subject.keyword.spa.fl_str_mv Malaria
P. falciparum
1H-NMR
HLA-DR?1* molecules
Immunogenic peptides
topic Malaria
P. falciparum
1H-NMR
HLA-DR?1* molecules
Immunogenic peptides
description As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells. Hundreds of experiments in large numbers of Aotus monkeys revealed that this immunological code of silence could be broken by shifting the polarity of some critical host cell binding residues in these HABPs by substituting F for R and vice versa, YW, LH, IN, PD, MK or E, CT, VN or S; there are special rules for A, G and S. 1H-nuclear magnetic resonance of these modified, immunogenic, protection-inducing HABPs and molecular modelling revealed that such modifications induced appropriate fitting into specific HLA-DR?1* Pockets, suggesting the presence of new pockets and a haplotype- and allele-specific conscious TCR. A highly immunogenic and protection-inducing anti-malarial vaccine can thus be produced.
publishDate 2008
dc.date.created.spa.fl_str_mv 2008-05
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:35Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:35Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.2174/157340608784325160
dc.identifier.issn.none.fl_str_mv ISSN: 1573-4064
EISSN: 1875-6638
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26945
url https://doi.org/10.2174/157340608784325160
https://repository.urosario.edu.co/handle/10336/26945
identifier_str_mv ISSN: 1573-4064
EISSN: 1875-6638
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 292
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 278
dc.relation.citationTitle.none.fl_str_mv Medicinal Chemistry
dc.relation.citationVolume.none.fl_str_mv Vol. 4
dc.relation.ispartof.spa.fl_str_mv Medicinal Chemistry, ISSN: 1573-4064;EISSN: 1875-6638, Vol.4, No.3 (2008); pp. 278-292
dc.relation.uri.spa.fl_str_mv https://www.eurekaselect.com/82668/article
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Bentham Science Publishers
dc.source.spa.fl_str_mv Medicinal Chemistry
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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