Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence
As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells....
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2008
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26945
- Acceso en línea:
- https://doi.org/10.2174/157340608784325160
https://repository.urosario.edu.co/handle/10336/26945
- Palabra clave:
- Malaria
P. falciparum
1H-NMR
HLA-DR?1* molecules
Immunogenic peptides
- Rights
- License
- Restringido (Acceso a grupos específicos)
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EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
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561fb322-adc5-402b-aba7-327f7564e559-1945960d6-2fe1-44f7-8364-43269b57c123-135e93ecb-65a2-41f4-8ee0-ec18e35368f6-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-176e03223-040d-4e46-864f-3bdecc8d2790-12020-08-19T14:40:35Z2020-08-19T14:40:35Z2008-05As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells. Hundreds of experiments in large numbers of Aotus monkeys revealed that this immunological code of silence could be broken by shifting the polarity of some critical host cell binding residues in these HABPs by substituting F for R and vice versa, YW, LH, IN, PD, MK or E, CT, VN or S; there are special rules for A, G and S. 1H-nuclear magnetic resonance of these modified, immunogenic, protection-inducing HABPs and molecular modelling revealed that such modifications induced appropriate fitting into specific HLA-DR?1* Pockets, suggesting the presence of new pockets and a haplotype- and allele-specific conscious TCR. A highly immunogenic and protection-inducing anti-malarial vaccine can thus be produced.application/pdfhttps://doi.org/10.2174/157340608784325160ISSN: 1573-4064EISSN: 1875-6638https://repository.urosario.edu.co/handle/10336/26945engBentham Science Publishers292No. 3278Medicinal ChemistryVol. 4Medicinal Chemistry, ISSN: 1573-4064;EISSN: 1875-6638, Vol.4, No.3 (2008); pp. 278-292 https://www.eurekaselect.com/82668/articleRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecMedicinal Chemistryinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMalariaP. falciparum1H-NMRHLA-DR?1* moleculesImmunogenic peptidesShifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silenceCambiar la polaridad de algunos residuos críticos en la unión de los péptidos de la malaria a las células huésped es un factor clave para romper el código de silencio de los antígenos conservadosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cifuentes, G.Bermudez, A.Rodriguez, R.Patarroyo, M. A.Patarroyo, M. E.10336/26945oai:repository.urosario.edu.co:10336/269452022-05-02 07:37:13.454897https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
dc.title.TranslatedTitle.spa.fl_str_mv |
Cambiar la polaridad de algunos residuos críticos en la unión de los péptidos de la malaria a las células huésped es un factor clave para romper el código de silencio de los antígenos conservados |
title |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
spellingShingle |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence Malaria P. falciparum 1H-NMR HLA-DR?1* molecules Immunogenic peptides |
title_short |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
title_full |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
title_fullStr |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
title_full_unstemmed |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
title_sort |
Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence |
dc.subject.keyword.spa.fl_str_mv |
Malaria P. falciparum 1H-NMR HLA-DR?1* molecules Immunogenic peptides |
topic |
Malaria P. falciparum 1H-NMR HLA-DR?1* molecules Immunogenic peptides |
description |
As microbes use many mechanisms for avoiding immunological pressure, new strategies must be developed to bypass the immunological code of silence of conserved, functionally-important amino acid sequences, such as those involved in high activity binding peptides (HABPs) attaching to their host cells. Hundreds of experiments in large numbers of Aotus monkeys revealed that this immunological code of silence could be broken by shifting the polarity of some critical host cell binding residues in these HABPs by substituting F for R and vice versa, YW, LH, IN, PD, MK or E, CT, VN or S; there are special rules for A, G and S. 1H-nuclear magnetic resonance of these modified, immunogenic, protection-inducing HABPs and molecular modelling revealed that such modifications induced appropriate fitting into specific HLA-DR?1* Pockets, suggesting the presence of new pockets and a haplotype- and allele-specific conscious TCR. A highly immunogenic and protection-inducing anti-malarial vaccine can thus be produced. |
publishDate |
2008 |
dc.date.created.spa.fl_str_mv |
2008-05 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:40:35Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:40:35Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.2174/157340608784325160 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 1573-4064 EISSN: 1875-6638 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26945 |
url |
https://doi.org/10.2174/157340608784325160 https://repository.urosario.edu.co/handle/10336/26945 |
identifier_str_mv |
ISSN: 1573-4064 EISSN: 1875-6638 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
292 |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationStartPage.none.fl_str_mv |
278 |
dc.relation.citationTitle.none.fl_str_mv |
Medicinal Chemistry |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 4 |
dc.relation.ispartof.spa.fl_str_mv |
Medicinal Chemistry, ISSN: 1573-4064;EISSN: 1875-6638, Vol.4, No.3 (2008); pp. 278-292 |
dc.relation.uri.spa.fl_str_mv |
https://www.eurekaselect.com/82668/article |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Bentham Science Publishers |
dc.source.spa.fl_str_mv |
Medicinal Chemistry |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167486404231168 |