Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance
Antecedentes: El cáncer es una de las enfermedades crónicas con mayor morbimortalidad a nivel mundial. Se ha incrementado la preferencia de terapias alternativas en pacientes con cáncer como es la Amigdalina, pero se desconoce la extensión y naturaleza de la literatura respecto de ésta. Objetivo: De...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/20396
- Acceso en línea:
- https://doi.org/10.48713/10336_20396
https://repository.urosario.edu.co/handle/10336/20396
- Palabra clave:
- Laetrile
Amigdalina
Amigdalosida
Neoplasia
Efectividad
Ciencias médicas, Medicina
Laetrile
Amygdalin
Amygdaloside
Neoplasm
Effectiveness
Medicina
Epidemiología
- Rights
- License
- Atribución-SinDerivadas 2.5 Colombia
id |
EDOCUR2_1ddb93a12efa4af90639f75fb15c7d22 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/20396 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
title |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
spellingShingle |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance Laetrile Amigdalina Amigdalosida Neoplasia Efectividad Ciencias médicas, Medicina Laetrile Amygdalin Amygdaloside Neoplasm Effectiveness Medicina Epidemiología |
title_short |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
title_full |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
title_fullStr |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
title_full_unstemmed |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
title_sort |
Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance |
dc.contributor.advisor.none.fl_str_mv |
Ondo Méndez, Alejandro Oyono Barragán González, Ana María |
dc.subject.spa.fl_str_mv |
Laetrile Amigdalina Amigdalosida Neoplasia Efectividad |
topic |
Laetrile Amigdalina Amigdalosida Neoplasia Efectividad Ciencias médicas, Medicina Laetrile Amygdalin Amygdaloside Neoplasm Effectiveness Medicina Epidemiología |
dc.subject.ddc.spa.fl_str_mv |
Ciencias médicas, Medicina |
dc.subject.keyword.spa.fl_str_mv |
Laetrile Amygdalin Amygdaloside Neoplasm Effectiveness |
dc.subject.lemb.spa.fl_str_mv |
Medicina Epidemiología |
description |
Antecedentes: El cáncer es una de las enfermedades crónicas con mayor morbimortalidad a nivel mundial. Se ha incrementado la preferencia de terapias alternativas en pacientes con cáncer como es la Amigdalina, pero se desconoce la extensión y naturaleza de la literatura respecto de ésta. Objetivo: Describir la naturaleza, variedad y extensión de la literatura alrededor del uso de Amigdalina en pacientes con cáncer. Metodología: Revisión sistemática de literatura de alcance. Se consultaron las bases MEDLINE a través de PUBMED, EMBASE, LILACS y literatura gris en google scholar. Se incluyeron estudios en humanos o tejido humano (in vitro) con cualquier tipo de cáncer, toda presentación y vías de administración de la Amigdalina. Tres revisores (SM, NC y BV) independientemente, tamizaron y extrajeron datos. Se sintetizó en: autores, año de publicación, país, tipo de estudio, tamaño de muestra, población y tipo de intervención. Resultados: De 2.402 referencias se removieron duplicados. En el tamizaje de título y resumen se excluyen 399 artículos. De 216 artículos completos se incluyeron 35 en la síntesis. Se reportaron revisiones narrativas (n = 15), estudios experimentales in vitro (n=12), reportes de casos (n=4), revisiones sistemáticas (n=2) y observacionales (n=2). El principal país en publicar fue Estados Unidos, seguido por Alemania. Discusión: No se recuperó toda la evidencia alrededor del uso de Amigdalina. Esto hace mas compleja la interpretación y el análisis de los datos recolectados. Conclusión: No hubo discrepancia entre los autores para no recomendar el uso de Amigdalina como tratamiento para pacientes con cáncer. |
publishDate |
2019 |
dc.date.accessioned.none.fl_str_mv |
2019-10-07T12:07:32Z |
dc.date.available.none.fl_str_mv |
2019-10-07T12:07:32Z |
dc.date.created.none.fl_str_mv |
2019-09-06 |
dc.type.eng.fl_str_mv |
bachelorThesis |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.document.spa.fl_str_mv |
Revisión sistemática |
dc.type.spa.spa.fl_str_mv |
Trabajo de grado |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.48713/10336_20396 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/20396 |
url |
https://doi.org/10.48713/10336_20396 https://repository.urosario.edu.co/handle/10336/20396 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.rights.spa.fl_str_mv |
Atribución-SinDerivadas 2.5 Colombia |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
dc.rights.uri.none.fl_str_mv |
http://creativecommons.org/licenses/by-nd/2.5/co/ |
rights_invalid_str_mv |
Atribución-SinDerivadas 2.5 Colombia Abierto (Texto Completo) http://creativecommons.org/licenses/by-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad del Rosario |
dc.publisher.department.spa.fl_str_mv |
Facultad de medicina |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.spa.fl_str_mv |
Muñoz NJM, Gómez FR, Martínez MLO, Lopez MGG. Instituto Nacional de Salud, Observatorio Nacional de Salud, Quinto Informe ONS: carga de enfermedad por enfermedades crónicas no transmisibles y discapacidad en Colombia. 2015;239. Available from: https://www.ins.gov.co/Direcciones/ONS/Informes/5. Carga de enfermedad ECNT.pdf Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J cancer [Internet]. 2015 Mar 1 [cited 2019 Jun 24];136(5):E359-86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25220842 OPS/OMS. OPS/OMS | Programa de Cáncer [Internet]. 2019. Available from: https://www.paho.org/hq/index.php?option=com_content&view=article&id=292:cancer-program&Itemid=3904&lang=es WHO. El diagnóstico temprano del cáncer salva vidas y reduce los costos de tratamiento [Internet]. 2017. Available from: https://www.who.int/es/news-room/detail/03-02-2017-early-cancer-diagnosis-saves-lives-cuts-treatment-costs Chu P-C, Hwang J-S, Wang J-D, Chang Y-Y. Estimation of the Financial Burden to the National Health Insurance for Patients with Major Cancers in Taiwan. J Formos Med Assoc [Internet]. 2008 Jan;107(1):54–63. Available from: https://linkinghub.elsevier.com/retrieve/pii/S092966460860008X González-Robledo MC, Wong R, Ornelas HA, Knaul FM. Costs of breast cancer care in Mexico: analysis of two insurance coverage scenarios. Ecancermedicalscience [Internet]. 2015 [cited 2019 Jun 25];9:587. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26557885 Cajaraville J Carreras J Massó M J Tamés GM. Sociedad española de farmacia hospitalaria .Oncologia, Capitulo 14. [cited 2019 Jul 3]; Available from: https://www.sefh.es/bibliotecavirtual/fhtomo2/CAP14.pdf Paul Symonds R, Foweraker K. Principles of chemotherapy and radiotherapy. Curr Obstet Gynaecol [Internet]. 2006 Apr 1 [cited 2019 Jun 24];16(2):100–6. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0957584706000205 Silvia Aibar et al. Manual de enfermería oncologica Instituto Nacional del Cáncer [Internet]. [cited 2019 Aug 27]. p. Pagina 23-29. Available from: http://www.msal.gob.ar/images/stories/bes/graficos/0000000011cnt-08-manual enfermeria_08-03.pdf Sadeghi M, Enferadi M, Shirazi A. External and internal radiation therapy: Past and future directions. J Cancer Res Ther [Internet]. 2010 [cited 2019 Jun 24];6(3):239. Available from: http://www.cancerjournal.net/text.asp?2010/6/3/239/73324 Cancer Reserach UK. Tratamiento para el cáncer | Cáncer en general | Cancer Research UK [Internet]. [cited 2019 Jul 7]. Available from: https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment Irmak Z, Tanrıverdi Ö, Ödemiş H, Demir Uysal D. Use of complementary and alternative medicine and quality of life of cancer patients who received chemotherapy in Turkey. Complement Ther Med [Internet]. 2019 [cited 2019 Jul 10];44:143–50. Available from: www.elsevier.com/locate/ctim Gzell C, Back M, Wheeler H, Bailey D, Foote M. Radiotherapy in Glioblastoma: the Past, the Present and the Future. Clin Oncol [Internet]. 2017 Jan [cited 2019 Sep 5];29(1):15–25. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0936655516303168 Longo DL (Dan L, Based on (expression): Harrison TR. Harrison’s hematology and oncology. XIX. New York : McGraw-Hill Education Medical, [2017]; 2017. 832 p. Calderillo Ruiz Miguel Quintana Quintana G. ONCOLOGÍA GENERAL PARA PROFESIONALES DE LA SALUD DE PRIMER CONTACTO [Internet]. Ciudad de Mexico; 2017 [cited 2019 Aug 27]. Available from: www.permanyer.com Mustian KM, Sprod LK, Janelsins M, Peppone LJ, Mohile S. Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review. Oncol Hematol Rev [Internet]. 2012 [cited 2019 Jul 10];8(2):81–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23667857 Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I, et al. Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer. N Engl J Med [Internet]. 1991 Jul 18 [cited 2019 Jul 7];325(3):164–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1711156 Asociación Española Contra el Cáncer. Tipos de terapias alternativas [Internet]. [cited 2019 Sep 5]. Available from: https://www.aecc.es/es/todo-sobre-cancer/tratamientos/otros-tratamientos/tipos-terapias-alternativas Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients. Support Care Cancer [Internet]. 2012 Jul [cited 2019 Sep 5];20(7):1479. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21818642 Geiger JL. The essential oil of ginger, Zingiber officinale, and anaesthesia. Int J Aromather [Internet]. 2005 Jan 1 [cited 2019 Sep 5];15(1):7–14. Available from: https://www.sciencedirect.com/science/article/pii/S0962456204001213 García-García RM, Palou-García E. Temas Selectos de Ingeneria de Alımentos. Fenselau C, Pallante S, Batzinger RP, Benson WR, Barron RP, Sheinin EB, et al. Mandelonitrile beta-glucuronide: synthesis and characterization. Science (80- ) [Internet]. 1977 Nov 11 [cited 2019 Jul 6];198(4317):625. Available from: http://science.sciencemag.org/content/198/4317/625.abstract Strugala GJ, Rauws AG, Elbers R. Intestinal first pass metabolism of amygdalin in the rat in vitro. Biochem Pharmacol [Internet]. 1986 Jul 1 [cited 2019 Jun 25];35(13):2123–8. Available from: https://www.sciencedirect.com/science/article/abs/pii/0006295286905800 Park H-J, Yoon S-H, Han L-S, Zheng L-T, Jung K-H, Uhm Y-K, et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol [Internet]. 2005 Sep 7 [cited 2019 Jul 11];11(33):5156–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16127745 Mani J, Rutz J, Maxeiner S, Juengel E, Bon D, Roos F, et al. Cyanide and lactate levels in patients during chronic oral amygdalin intake followed by intravenous amygdalin administration. Complement Ther Med [Internet]. 2019 [cited 2019 Jun 25];43:295–9. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L2001686031 Moertel CG, Ames MM, Kovach JS, Moyer TP, Rubin JR, Tinker JH. A pharmacologic and toxicological study of amygdalin. JAMA. 1981 Feb;245(6):591–4. Jiagang D, Li C, Wang H, Hao E, Du Z, Bao C, et al. Amygdalin mediates relieved atherosclerosis in apolipoprotein E deficient mice through the induction of regulatory T cells. Biochem Biophys Res Commun [Internet]. 2011 Aug 5 [cited 2019 Jul 11];411(3):523–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21756879 Peters M, Godfrey C, Khalil H, Mcinerney P, Soares C, Parker D. 2017 Guidance for the Conduct of JBI Scoping Reviews. In 2017. Li Qiang, Xu Xiaoqin, Li Yan DH. Study on Acid Hydrolysis Condition of Amygdalin--《Modern Chinese Medicine》2009年01期 [Internet]. 2009. [cited 2019 Jul 11]. Available from: http://en.cnki.com.cn/Article_en/CJFDTotal-YJXX200901013.htm Urry LA, Cain ML, Wasserman SA, Minorsky P V., Reece JB. Campbell Biology in Focus + Masteringbiology With Etext Access Card. Benjamin-Cummings Pub Co; 2015. Kroemer G, Pouyssegur J. Tumor Cell Metabolism: Cancer’s Achilles’ Heel. Cancer Cell [Internet]. 2008 Jun [cited 2019 Aug 28];13(6):472–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18538731 Warburg O. On the Origin of Cancer Cells. Science (80- ). 1956 Feb;123(3191):309–14. Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci [Internet]. 2007 Apr 10 [cited 2019 Aug 29];104(15):6223–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17384149 Park J-H, Seo B-I, Cho S-Y, Park K-R, Choi S-H, Han C-K, et al. Single oral dose toxicity study of prebrewed armeniacae semen in rats. Toxicol Res [Internet]. 2013 Jun 30 [cited 2019 Aug 5];29(2):91–8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24278634 Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev [Internet]. 2007 Jul 24 [cited 2019 Aug 29];26(2):299–310. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17415526 Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood [Internet]. 2007 May 1 [cited 2019 Aug 29];109(9):3812–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17255361 Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma. Cancer Res [Internet]. 2006 Jan 15 [cited 2019 Aug 29];66(2):632–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16423989 Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer. 2008 Sep;8(9):705–13. Kaelin WG, Thompson CB. Clues from cell metabolism. Nature. 2010 Jun;465(7298):562–4. Wu K, Yang M. Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection. Biosci Rep. 2011 Dec;31(6):449–55. Singleterry J, Sreedhar A, Zhao Y. Components of cancer metabolism and therapeutic interventions. Mitochondrion. 2014 Jul;17:50–5. Hsu PP, Sabatini DM. Cancer Cell Metabolism: Warburg and Beyond. Cell. 2008 Sep;134(5):703–7. J. S, Q. C, M. X, Q. X, T. Z, J. T, et al. Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review. Cancer Med [Internet]. 2019;8(6):3004–11. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L628102327 X Y. Advances in anti‐tumor mechanism of Guangxi Chinese herbal medicine. J Liaoning Univ Tradit Chin Med. 2012;14((05)):60–2. Orlikova B, Legrand N, Panning J et al. Anti‐inflammatory and anticancer drugs from nature. Cancer Treat Res. 2014;159:123–43. Lea MA, Koch MR. Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat. J Natl Cancer Inst. 1979 Nov;63(5):1279–83. Makarević J, Tsaur I, Juengel E, Borgmann H, Nelson K, Thomas C, et al. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sci [Internet]. 2016 Feb 15 [cited 2019 Jul 11];147:137–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26827990 A.C. T, I. K, I. R, D. Z, D.M.-Y. S. Potential antioxidant, antiinflammatory, and proapoptotic anticancer activities of Kakadu plum and Illawarra plum polyphenolic fractions. Nutr Cancer [Internet]. 2011;63(7):1074–84. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L362711925 Basu TK. High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in guinea pigs. Can J Physiol Pharmacol. 1983 Nov;61(11):1426–30. Miller KW, Anderson JL, Stoewsand GS. Amygdalin metabolism and effect on reproduction of rats fed apricot kernels. J Toxicol Environ Health. 1981;7(3–4):457–67. X N. Research Progress of Amygdalin. Nei Mong J Tradit Chin Med. 2012;31(9):66‐67. Lee H, Moon A. Amygdalin regula la apoptosis y la adhesión en células de cáncer de mama triple negativo Hs578T. Biomol Ther (Seoul) [Internet]. 2016 [cited 2019 Aug 10]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703354/ Tang F, Fan K, Wang K, Bian C. Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways. Biomed Pharmacother [Internet]. 2019 Mar 1 [cited 2019 Jul 11];111:527–36. Available from: https://www.sciencedirect.com/science/article/pii/S075333221833693X?via%3Dihub A. Z, W. P, J. L, H. W, Zhang A, Pan W, et al. Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3 Signaling Pathways. Inflammation [Internet]. 2017 Jun;40(3):1–7. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L617935203 P. L, B. B. Molecular mechanism of amygdalin action in vitro: review of the latest research. Immunopharmacol Immunotoxicol [Internet]. 2018;40(3):212–8. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L622211455 A E, Z F, H H, I I, M K, M O. Rayyan: a systematic reviews web app for exploring and filtering searches for eligible studies for Cochrane Reviews. In: Abstracts of the 22nd Cochrane Colloquium. John Wiley & Sons; 2014. p. 9. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med [Internet]. 2018 Oct 2 [cited 2019 Sep 6];169(7):467. Available from: http://annals.org/article.aspx?doi=10.7326/M18-0850 Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How Many Cancer Patients Use Complementary and Alternative Medicine: A Systematic Review and Metaanalysis. Integr Cancer Ther [Internet]. 2011 Jun 6 [cited 2019 Jul 3];11(3):187–203. Available from: http://ict.sagepub.com Moertel CG, Fleming TR, Rubin J, Kvols LK, Sarna G, Koch R, et al. A Clinical Trial of Amygdalin (Laetrile) in the Treatment of Human Cancer. N Engl J Med [Internet]. 1982 Jan 2 [cited 2019 Jul 21];306(4):201–6. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM198201283060403 C. F, R. B, L. B, J. VE, Faw C, Ballentine R, et al. Unproved cancer remedies. A survey of use in pediatric outpatients. J Am Med Assoc [Internet]. 1977 Oct;238(14):1536–8. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L8204633 Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Support Care Cancer [Internet]. 2007;15(6):583–95. Available from: http://dx.doi.org/10.1007/s00520-006-0168-9 |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/d7bc69c6-74ce-4100-b98e-33e7e6ecd23f/download https://repository.urosario.edu.co/bitstreams/59323b4c-3edb-4d45-af0e-48c15a91d31c/download https://repository.urosario.edu.co/bitstreams/78203d2e-053d-4f80-89c4-3931aa097be7/download https://repository.urosario.edu.co/bitstreams/4cd6da77-f745-46db-918b-bcf077f19948/download https://repository.urosario.edu.co/bitstreams/11c6957b-9472-43fc-ac77-38498f5107c2/download |
bitstream.checksum.fl_str_mv |
04d44ff3c29263e32c948a5124eb273a fab9d9ed61d64f6ac005dee3306ae77e dab767be7a093b539031785b3bf95490 ef3b134a9412d420c877dfbb7901907a a68a616b1a13baa7daac2c3f0b306963 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167528595783680 |
spelling |
Ondo Méndez, Alejandro Oyono79831981600Barragán González, Ana María52666902600Milanés Escobar, Sonia AlejandraCuadrado Velásquez, Nelia PatriciaDel Valle Zapata, Brenda MilenaEspecialista en Epidemiología (en Convenio con el CES)Full time5cdb3863-8f47-4828-86c1-4eae972d2b8960001733f36-1a60-49b0-9c1b-2ecd51d554a2600e3db1791-d2ee-4880-9b72-96e8951255256002019-10-07T12:07:32Z2019-10-07T12:07:32Z2019-09-06Antecedentes: El cáncer es una de las enfermedades crónicas con mayor morbimortalidad a nivel mundial. Se ha incrementado la preferencia de terapias alternativas en pacientes con cáncer como es la Amigdalina, pero se desconoce la extensión y naturaleza de la literatura respecto de ésta. Objetivo: Describir la naturaleza, variedad y extensión de la literatura alrededor del uso de Amigdalina en pacientes con cáncer. Metodología: Revisión sistemática de literatura de alcance. Se consultaron las bases MEDLINE a través de PUBMED, EMBASE, LILACS y literatura gris en google scholar. Se incluyeron estudios en humanos o tejido humano (in vitro) con cualquier tipo de cáncer, toda presentación y vías de administración de la Amigdalina. Tres revisores (SM, NC y BV) independientemente, tamizaron y extrajeron datos. Se sintetizó en: autores, año de publicación, país, tipo de estudio, tamaño de muestra, población y tipo de intervención. Resultados: De 2.402 referencias se removieron duplicados. En el tamizaje de título y resumen se excluyen 399 artículos. De 216 artículos completos se incluyeron 35 en la síntesis. Se reportaron revisiones narrativas (n = 15), estudios experimentales in vitro (n=12), reportes de casos (n=4), revisiones sistemáticas (n=2) y observacionales (n=2). El principal país en publicar fue Estados Unidos, seguido por Alemania. Discusión: No se recuperó toda la evidencia alrededor del uso de Amigdalina. Esto hace mas compleja la interpretación y el análisis de los datos recolectados. Conclusión: No hubo discrepancia entre los autores para no recomendar el uso de Amigdalina como tratamiento para pacientes con cáncer.Background: Cancer is one of the chronic diseases with the highest morbidity and mortality worldwide. The preference of alternative therapies in patients with cancer such as Amygdalin has increased, but the extent and nature of the literature regarding this is unknown. Objective: Describe the nature, variety and extent of the literature surrounding the use of Amygdalin in cancer patients. Methodology: Systematic review of scope literature. The MEDLINE bases were consulted through PUBMED, EMBASE, LILACS and gray literature in google scholar. Studies in human or human tissue (in vitro) with any type of cancer, all presentation and routes of administration of Amygdalin were included. Three reviewers (SM, NC and BV) independently screened and extracted data. It was synthesized in: authors, year of publication, country, type of study, sample size, population and type of intervention. Results: Duplicates were removed from 2,402 references. 399 articles are excluded in title and summary screening. Of 216 full articles, 35 were included in the synthesis. Narrative reviews (n=15), experimental in vitro studies (n=12), case reports (n=4), systematic reviews (n=2) and observational (n=2) were reported. The main country to publish was the United States, followed by Germany. Discussion: All evidence surrounding the use of Amygdalin was not recovered. This makes the interpretation and analysis of the data collected more complex. Conclusion: There was no discrepancy among the authors for not recommending the use of Amygdalin as a treatment for cancer patients.2019-10-07 07:15:01: Script de automatizacion de embargos. 7 de octubre El autor selecciona el tipo de acceso restringido, se asigna embargo por dos años. Se ha realizado la publicación de su documento "Uso de Amigdalina en pacientes con cáncer: revisión sistemática de alcance" en el Repositorio Institucional EdocUR de la Universidad del Rosario. Usted escogió la opción "Restringido (Temporalmente bloqueado)", por lo que el documento ha quedado con embargo hasta el 8 de octubre de 2021, en concordancia con las Políticas de Acceso Abierto de la Universidad. Si usted desea dejarlo con acceso abierto antes de finalizar dicho periodo o si por el contrario desea extender el embargo al finalizar este tiempo, puede enviar un correo a esta misma dirección realizando la solicitud. Tenga en cuenta que los documentos en acceso abierto propician una mayor visibilidad de su producción académica y científica. Se le envía correo 7 de octubre 2019 informando el tiempo de embargo del documento.2021-10-08 01:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2021-10-07application/pdfhttps://doi.org/10.48713/10336_20396 https://repository.urosario.edu.co/handle/10336/20396spaUniversidad del RosarioFacultad de medicinaAtribución-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nd/2.5/co/http://purl.org/coar/access_right/c_abf2Muñoz NJM, Gómez FR, Martínez MLO, Lopez MGG. Instituto Nacional de Salud, Observatorio Nacional de Salud, Quinto Informe ONS: carga de enfermedad por enfermedades crónicas no transmisibles y discapacidad en Colombia. 2015;239. Available from: https://www.ins.gov.co/Direcciones/ONS/Informes/5. Carga de enfermedad ECNT.pdfFerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J cancer [Internet]. 2015 Mar 1 [cited 2019 Jun 24];136(5):E359-86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25220842OPS/OMS. OPS/OMS | Programa de Cáncer [Internet]. 2019. Available from: https://www.paho.org/hq/index.php?option=com_content&view=article&id=292:cancer-program&Itemid=3904&lang=esWHO. El diagnóstico temprano del cáncer salva vidas y reduce los costos de tratamiento [Internet]. 2017. Available from: https://www.who.int/es/news-room/detail/03-02-2017-early-cancer-diagnosis-saves-lives-cuts-treatment-costsChu P-C, Hwang J-S, Wang J-D, Chang Y-Y. Estimation of the Financial Burden to the National Health Insurance for Patients with Major Cancers in Taiwan. J Formos Med Assoc [Internet]. 2008 Jan;107(1):54–63. Available from: https://linkinghub.elsevier.com/retrieve/pii/S092966460860008XGonzález-Robledo MC, Wong R, Ornelas HA, Knaul FM. Costs of breast cancer care in Mexico: analysis of two insurance coverage scenarios. Ecancermedicalscience [Internet]. 2015 [cited 2019 Jun 25];9:587. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26557885Cajaraville J Carreras J Massó M J Tamés GM. Sociedad española de farmacia hospitalaria .Oncologia, Capitulo 14. [cited 2019 Jul 3]; Available from: https://www.sefh.es/bibliotecavirtual/fhtomo2/CAP14.pdfPaul Symonds R, Foweraker K. Principles of chemotherapy and radiotherapy. Curr Obstet Gynaecol [Internet]. 2006 Apr 1 [cited 2019 Jun 24];16(2):100–6. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0957584706000205Silvia Aibar et al. Manual de enfermería oncologica Instituto Nacional del Cáncer [Internet]. [cited 2019 Aug 27]. p. Pagina 23-29. Available from: http://www.msal.gob.ar/images/stories/bes/graficos/0000000011cnt-08-manual enfermeria_08-03.pdfSadeghi M, Enferadi M, Shirazi A. External and internal radiation therapy: Past and future directions. J Cancer Res Ther [Internet]. 2010 [cited 2019 Jun 24];6(3):239. Available from: http://www.cancerjournal.net/text.asp?2010/6/3/239/73324Cancer Reserach UK. Tratamiento para el cáncer | Cáncer en general | Cancer Research UK [Internet]. [cited 2019 Jul 7]. Available from: https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatmentIrmak Z, Tanrıverdi Ö, Ödemiş H, Demir Uysal D. Use of complementary and alternative medicine and quality of life of cancer patients who received chemotherapy in Turkey. Complement Ther Med [Internet]. 2019 [cited 2019 Jul 10];44:143–50. Available from: www.elsevier.com/locate/ctimGzell C, Back M, Wheeler H, Bailey D, Foote M. Radiotherapy in Glioblastoma: the Past, the Present and the Future. Clin Oncol [Internet]. 2017 Jan [cited 2019 Sep 5];29(1):15–25. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0936655516303168Longo DL (Dan L, Based on (expression): Harrison TR. Harrison’s hematology and oncology. XIX. New York : McGraw-Hill Education Medical, [2017]; 2017. 832 p.Calderillo Ruiz Miguel Quintana Quintana G. ONCOLOGÍA GENERAL PARA PROFESIONALES DE LA SALUD DE PRIMER CONTACTO [Internet]. Ciudad de Mexico; 2017 [cited 2019 Aug 27]. Available from: www.permanyer.comMustian KM, Sprod LK, Janelsins M, Peppone LJ, Mohile S. Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review. Oncol Hematol Rev [Internet]. 2012 [cited 2019 Jul 10];8(2):81–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23667857Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I, et al. Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer. N Engl J Med [Internet]. 1991 Jul 18 [cited 2019 Jul 7];325(3):164–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1711156Asociación Española Contra el Cáncer. Tipos de terapias alternativas [Internet]. [cited 2019 Sep 5]. Available from: https://www.aecc.es/es/todo-sobre-cancer/tratamientos/otros-tratamientos/tipos-terapias-alternativasRyan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients. Support Care Cancer [Internet]. 2012 Jul [cited 2019 Sep 5];20(7):1479. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21818642Geiger JL. The essential oil of ginger, Zingiber officinale, and anaesthesia. Int J Aromather [Internet]. 2005 Jan 1 [cited 2019 Sep 5];15(1):7–14. Available from: https://www.sciencedirect.com/science/article/pii/S0962456204001213García-García RM, Palou-García E. Temas Selectos de Ingeneria de Alımentos.Fenselau C, Pallante S, Batzinger RP, Benson WR, Barron RP, Sheinin EB, et al. Mandelonitrile beta-glucuronide: synthesis and characterization. Science (80- ) [Internet]. 1977 Nov 11 [cited 2019 Jul 6];198(4317):625. Available from: http://science.sciencemag.org/content/198/4317/625.abstractStrugala GJ, Rauws AG, Elbers R. Intestinal first pass metabolism of amygdalin in the rat in vitro. Biochem Pharmacol [Internet]. 1986 Jul 1 [cited 2019 Jun 25];35(13):2123–8. Available from: https://www.sciencedirect.com/science/article/abs/pii/0006295286905800Park H-J, Yoon S-H, Han L-S, Zheng L-T, Jung K-H, Uhm Y-K, et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol [Internet]. 2005 Sep 7 [cited 2019 Jul 11];11(33):5156–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16127745Mani J, Rutz J, Maxeiner S, Juengel E, Bon D, Roos F, et al. Cyanide and lactate levels in patients during chronic oral amygdalin intake followed by intravenous amygdalin administration. Complement Ther Med [Internet]. 2019 [cited 2019 Jun 25];43:295–9. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L2001686031Moertel CG, Ames MM, Kovach JS, Moyer TP, Rubin JR, Tinker JH. A pharmacologic and toxicological study of amygdalin. JAMA. 1981 Feb;245(6):591–4.Jiagang D, Li C, Wang H, Hao E, Du Z, Bao C, et al. Amygdalin mediates relieved atherosclerosis in apolipoprotein E deficient mice through the induction of regulatory T cells. Biochem Biophys Res Commun [Internet]. 2011 Aug 5 [cited 2019 Jul 11];411(3):523–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21756879Peters M, Godfrey C, Khalil H, Mcinerney P, Soares C, Parker D. 2017 Guidance for the Conduct of JBI Scoping Reviews. In 2017.Li Qiang, Xu Xiaoqin, Li Yan DH. Study on Acid Hydrolysis Condition of Amygdalin--《Modern Chinese Medicine》2009年01期 [Internet]. 2009. [cited 2019 Jul 11]. Available from: http://en.cnki.com.cn/Article_en/CJFDTotal-YJXX200901013.htmUrry LA, Cain ML, Wasserman SA, Minorsky P V., Reece JB. Campbell Biology in Focus + Masteringbiology With Etext Access Card. Benjamin-Cummings Pub Co; 2015.Kroemer G, Pouyssegur J. Tumor Cell Metabolism: Cancer’s Achilles’ Heel. Cancer Cell [Internet]. 2008 Jun [cited 2019 Aug 28];13(6):472–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18538731Warburg O. On the Origin of Cancer Cells. Science (80- ). 1956 Feb;123(3191):309–14.Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci [Internet]. 2007 Apr 10 [cited 2019 Aug 29];104(15):6223–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17384149Park J-H, Seo B-I, Cho S-Y, Park K-R, Choi S-H, Han C-K, et al. Single oral dose toxicity study of prebrewed armeniacae semen in rats. Toxicol Res [Internet]. 2013 Jun 30 [cited 2019 Aug 5];29(2):91–8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24278634Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev [Internet]. 2007 Jul 24 [cited 2019 Aug 29];26(2):299–310. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17415526Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood [Internet]. 2007 May 1 [cited 2019 Aug 29];109(9):3812–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17255361Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma. Cancer Res [Internet]. 2006 Jan 15 [cited 2019 Aug 29];66(2):632–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16423989Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer. 2008 Sep;8(9):705–13.Kaelin WG, Thompson CB. Clues from cell metabolism. Nature. 2010 Jun;465(7298):562–4.Wu K, Yang M. Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection. Biosci Rep. 2011 Dec;31(6):449–55.Singleterry J, Sreedhar A, Zhao Y. Components of cancer metabolism and therapeutic interventions. Mitochondrion. 2014 Jul;17:50–5.Hsu PP, Sabatini DM. Cancer Cell Metabolism: Warburg and Beyond. Cell. 2008 Sep;134(5):703–7.J. S, Q. C, M. X, Q. X, T. Z, J. T, et al. Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review. Cancer Med [Internet]. 2019;8(6):3004–11. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L628102327X Y. Advances in anti‐tumor mechanism of Guangxi Chinese herbal medicine. J Liaoning Univ Tradit Chin Med. 2012;14((05)):60–2.Orlikova B, Legrand N, Panning J et al. Anti‐inflammatory and anticancer drugs from nature. Cancer Treat Res. 2014;159:123–43.Lea MA, Koch MR. Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat. J Natl Cancer Inst. 1979 Nov;63(5):1279–83.Makarević J, Tsaur I, Juengel E, Borgmann H, Nelson K, Thomas C, et al. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sci [Internet]. 2016 Feb 15 [cited 2019 Jul 11];147:137–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26827990A.C. T, I. K, I. R, D. Z, D.M.-Y. S. Potential antioxidant, antiinflammatory, and proapoptotic anticancer activities of Kakadu plum and Illawarra plum polyphenolic fractions. Nutr Cancer [Internet]. 2011;63(7):1074–84. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L362711925Basu TK. High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in guinea pigs. Can J Physiol Pharmacol. 1983 Nov;61(11):1426–30.Miller KW, Anderson JL, Stoewsand GS. Amygdalin metabolism and effect on reproduction of rats fed apricot kernels. J Toxicol Environ Health. 1981;7(3–4):457–67.X N. Research Progress of Amygdalin. Nei Mong J Tradit Chin Med. 2012;31(9):66‐67.Lee H, Moon A. Amygdalin regula la apoptosis y la adhesión en células de cáncer de mama triple negativo Hs578T. Biomol Ther (Seoul) [Internet]. 2016 [cited 2019 Aug 10]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703354/Tang F, Fan K, Wang K, Bian C. Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways. Biomed Pharmacother [Internet]. 2019 Mar 1 [cited 2019 Jul 11];111:527–36. Available from: https://www.sciencedirect.com/science/article/pii/S075333221833693X?via%3DihubA. Z, W. P, J. L, H. W, Zhang A, Pan W, et al. Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3 Signaling Pathways. Inflammation [Internet]. 2017 Jun;40(3):1–7. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L617935203P. L, B. B. Molecular mechanism of amygdalin action in vitro: review of the latest research. Immunopharmacol Immunotoxicol [Internet]. 2018;40(3):212–8. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L622211455A E, Z F, H H, I I, M K, M O. Rayyan: a systematic reviews web app for exploring and filtering searches for eligible studies for Cochrane Reviews. In: Abstracts of the 22nd Cochrane Colloquium. John Wiley & Sons; 2014. p. 9.Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med [Internet]. 2018 Oct 2 [cited 2019 Sep 6];169(7):467. Available from: http://annals.org/article.aspx?doi=10.7326/M18-0850Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How Many Cancer Patients Use Complementary and Alternative Medicine: A Systematic Review and Metaanalysis. Integr Cancer Ther [Internet]. 2011 Jun 6 [cited 2019 Jul 3];11(3):187–203. Available from: http://ict.sagepub.comMoertel CG, Fleming TR, Rubin J, Kvols LK, Sarna G, Koch R, et al. A Clinical Trial of Amygdalin (Laetrile) in the Treatment of Human Cancer. N Engl J Med [Internet]. 1982 Jan 2 [cited 2019 Jul 21];306(4):201–6. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM198201283060403C. F, R. B, L. B, J. VE, Faw C, Ballentine R, et al. Unproved cancer remedies. A survey of use in pediatric outpatients. J Am Med Assoc [Internet]. 1977 Oct;238(14):1536–8. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L8204633Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Support Care Cancer [Internet]. 2007;15(6):583–95. Available from: http://dx.doi.org/10.1007/s00520-006-0168-9instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURLaetrileAmigdalinaAmigdalosidaNeoplasiaEfectividadCiencias médicas, Medicina610600LaetrileAmygdalinAmygdalosideNeoplasmEffectivenessMedicinaEpidemiologíaUso de Amigdalina en pacientes con cáncer: revisión sistemática de alcancebachelorThesisRevisión sistemáticaTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fORIGINALMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdfMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdfapplication/pdf603628https://repository.urosario.edu.co/bitstreams/d7bc69c6-74ce-4100-b98e-33e7e6ecd23f/download04d44ff3c29263e32c948a5124eb273aMD51LICENSElicense.txtlicense.txttext/plain1475https://repository.urosario.edu.co/bitstreams/59323b4c-3edb-4d45-af0e-48c15a91d31c/downloadfab9d9ed61d64f6ac005dee3306ae77eMD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repository.urosario.edu.co/bitstreams/78203d2e-053d-4f80-89c4-3931aa097be7/downloaddab767be7a093b539031785b3bf95490MD53TEXTMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdf.txtMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdf.txtExtracted texttext/plain87458https://repository.urosario.edu.co/bitstreams/4cd6da77-f745-46db-918b-bcf077f19948/downloadef3b134a9412d420c877dfbb7901907aMD54THUMBNAILMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdf.jpgMilanes Sonia, Cuadrado Nelia, Del Valle Brenda.pdf.jpgGenerated Thumbnailimage/jpeg2443https://repository.urosario.edu.co/bitstreams/11c6957b-9472-43fc-ac77-38498f5107c2/downloada68a616b1a13baa7daac2c3f0b306963MD5510336/20396oai:repository.urosario.edu.co:10336/203962021-10-08 01:01:02.116614http://creativecommons.org/licenses/by-nd/2.5/co/Atribución-SinDerivadas 2.5 Colombiahttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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 |