Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus

Objective: To estimate the common effect size of HLA-DRB1 and -DQB1 alleles on systemic lupus erythematosus (SLE) susceptibility across Latin America populations through a meta-analysis. Methods: Case-control studies on HLA class II association with SLE in Latin America were searched up to August 2007. The effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: Eleven studies were selected, which included 747 cases and 1180 controls. Associations with SLE susceptibility were found for HLA-DR2 (OR: 1.75; 95% CI: 1.40-2.19) and -DR3 (OR: 2.02; 95% CI: 1.44-2.83) groups. HLA-DRB1*0301 allele disclosed the strongest association (OR: 2.14; 95% CI: 1.28-3.56). HLA-DR3-DQ2 haplotype was a risk factor (OR: 2.92; 95% CI: 1.66-5.14). A protective effect was found for the HLA-DR5 group (OR: 0.43; 95% CI: 0.27-0.67), mainly due to a negative association between HLA-DRB1*1101 allele and disease (OR: 0.21; 95% CI: 0.06-0.72). Functional analysis of susceptibility and protective alleles revealed physicochemical differences of critical amino acids shaping the peptide-binding groove at DR? chain allowing us to infer an approach to understand the role of HLA in SLE. No significant association was established for HLA-DQB1 alleles. Conclusions: HLA-DRB1 gene is a mayor factor for development of SLE in Latin Americans. © 2007 Elsevier B.V. All rights reserved.

• Fecha de publicación: 2008
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23345
• Acceso en línea: https://doi.org/10.1016/j.autrev.2007.12.002; https://repository.urosario.edu.co/handle/10336/23345
• Palabra clave: Amino acid; Hla dqb1 antigen; Hla dr antigen; Peptide; Allele; Case control study; Confidence interval; Controlled study; Data extraction; Female; Genetic polymorphism; Genotype; Haplotype; Human; Major clinical study; Physical chemistry; Review; South and central america; Statistical analysis; Systemic lupus erythematosus; Adult; Alleles; Case-control studies; Female; Gene frequency; Genetic predisposition to disease; Genotype; Haplotypes; Hla-dq antigens; Hla-dr antigens; Humans; Latin america; Middle aged; Hla antigens/alleles; Hla haplotypes; Latin america; Meta-analysis; Systemic lupus erythematosus; genetic; systemic; Lupus erythematosus; Polymorphism
• License: Abierto (Texto Completo)