Obstetric antiphospholipid syndrome

Antiphospholipid syndrome (APS) in pregnancy has a serious impact on maternal and fetal morbidity. It causes recurrent pregnancy miscarriage and it is associated with other adverse obstetric findings like preterm delivery, intrauterine growth restriction, preeclampsia, HELLP syndrome and others. The 2006 revised criteria, which is still valid, is used for APS classification. Epidemiology of obstetric APS varies from one population group to another largely due to different inclusion criteria and lack of standardization of antibody detection methods. Treatment is still controversial. This topic should include a multidisciplinary team and should be individualized. Success here is based on strict control and monitoring throughout pregnancy and even in the preconception and postpartum periods. Further research in this field and unification of criteria are required to yield better therapeutic strategies in the future. © 2011 Elsevier B.V.

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23166
• Acceso en línea: https://doi.org/10.1016/j.autrev.2011.10.006; https://repository.urosario.edu.co/handle/10336/23166
• Palabra clave: Acetylsalicylic acid; Antibody; Antithrombin; Autoantibody; Beta 2 glycoprotein 1 antibody; Betamethasone; Cardiolipin antibody; Dalteparin; Dexamethasone; Enoxaparin; Heparin; Low molecular weight heparin; Lupus anticoagulant; Nadroparin; Prednisolone; Prednisone; Unclassified drug; Warfarin; Antibody detection; Antiphospholipid syndrome; Autoimmune disease; Human; Hypercoagulability; Laboratory test; Low drug dose; Morbidity; Nonhuman; Preconception injury; Pregnancy; Puerperium; Review; Spontaneous abortion; Standardization; Teratogenicity; Thrombosis; Vascular disease; Animals; Antibody-dependent cell cytotoxicity; Antiphospholipid syndrome; Aspirin; Blood coagulation; Female; Heparin; Humans; Immunotherapy; Individualized medicine; Mice; Pregnancy; Pregnancy complications; Antiphospholipid antibodies; Obstetric antiphospholipid syndrome; Recurrent pregnancy miscarriage; habitual; animal; antiphospholipid; Abortion; Antibodies; Disease models
• License: Abierto (Texto Completo)