P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminida...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2003
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26683
- Acceso en línea:
- https://doi.org/10.1016/S0196-9781(03)00185-2
https://repository.urosario.edu.co/handle/10336/26683
- Palabra clave:
- P. falciparum
MSP-8
High activity binding peptides
Critical residues
Invasion inhibition
- Rights
- License
- Restringido (Acceso a grupos específicos)
id |
EDOCUR2_1a1e82a31ee4dd53b2d71f7d9da100fd |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/26683 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
51721018-1fa33b517-50cf-4bb5-a980-3773caf84cd8-15e82e691-ba88-4d28-b934-b924d1350834-1eba5265c-2b9f-49a4-8c8c-4e3459a41e19-1a4e7ff19-544a-44fe-ad9c-61d4aff3b8ba-1518488266002020-08-19T14:40:02Z2020-08-19T14:40:02Z2003-07This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein’s possible role in the invasion process.application/pdfhttps://doi.org/10.1016/S0196-9781(03)00185-2ISSN: 0196-9781EISSN: 1873-5169https://repository.urosario.edu.co/handle/10336/26683engElsevier1023No. 71015PeptidesVol. 24Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.24, No.7 (July 2003); pp. 1015-1023 https://www.sciencedirect.com/science/article/abs/pii/S0196978103001852?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecPeptidesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURP. falciparumMSP-8High activity binding peptidesCritical residuesInvasion inhibitionP. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.P. falciparum: Los péptidos de la proteína de superficie 8 de merezoito se unen específicamente a los eritrocitos humanos.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Vanegas, MagnoliaTovar, DianaLópez, RamsesPuentes, ALvaroGarcía, JavierOcampo, Marisol10336/26683oai:repository.urosario.edu.co:10336/266832021-06-03 00:49:57.495https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
dc.title.TranslatedTitle.spa.fl_str_mv |
P. falciparum: Los péptidos de la proteína de superficie 8 de merezoito se unen específicamente a los eritrocitos humanos. |
title |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
spellingShingle |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. P. falciparum MSP-8 High activity binding peptides Critical residues Invasion inhibition |
title_short |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
title_full |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
title_fullStr |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
title_full_unstemmed |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
title_sort |
P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes. |
dc.subject.keyword.spa.fl_str_mv |
P. falciparum MSP-8 High activity binding peptides Critical residues Invasion inhibition |
topic |
P. falciparum MSP-8 High activity binding peptides Critical residues Invasion inhibition |
description |
This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein’s possible role in the invasion process. |
publishDate |
2003 |
dc.date.created.spa.fl_str_mv |
2003-07 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:40:02Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:40:02Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/S0196-9781(03)00185-2 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0196-9781 EISSN: 1873-5169 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26683 |
url |
https://doi.org/10.1016/S0196-9781(03)00185-2 https://repository.urosario.edu.co/handle/10336/26683 |
identifier_str_mv |
ISSN: 0196-9781 EISSN: 1873-5169 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
1023 |
dc.relation.citationIssue.none.fl_str_mv |
No. 7 |
dc.relation.citationStartPage.none.fl_str_mv |
1015 |
dc.relation.citationTitle.none.fl_str_mv |
Peptides |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 24 |
dc.relation.ispartof.spa.fl_str_mv |
Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.24, No.7 (July 2003); pp. 1015-1023 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S0196978103001852?via%3Dihub |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.source.spa.fl_str_mv |
Peptides |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167462166396928 |