P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.

This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminida...

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Autores:
Tipo de recurso:
Fecha de publicación:
2003
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26683
Acceso en línea:
https://doi.org/10.1016/S0196-9781(03)00185-2
https://repository.urosario.edu.co/handle/10336/26683
Palabra clave:
P. falciparum
MSP-8
High activity binding peptides
Critical residues
Invasion inhibition
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_1a1e82a31ee4dd53b2d71f7d9da100fd
oai_identifier_str oai:repository.urosario.edu.co:10336/26683
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 51721018-1fa33b517-50cf-4bb5-a980-3773caf84cd8-15e82e691-ba88-4d28-b934-b924d1350834-1eba5265c-2b9f-49a4-8c8c-4e3459a41e19-1a4e7ff19-544a-44fe-ad9c-61d4aff3b8ba-1518488266002020-08-19T14:40:02Z2020-08-19T14:40:02Z2003-07This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein’s possible role in the invasion process.application/pdfhttps://doi.org/10.1016/S0196-9781(03)00185-2ISSN: 0196-9781EISSN: 1873-5169https://repository.urosario.edu.co/handle/10336/26683engElsevier1023No. 71015PeptidesVol. 24Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.24, No.7 (July 2003); pp. 1015-1023 https://www.sciencedirect.com/science/article/abs/pii/S0196978103001852?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecPeptidesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURP. falciparumMSP-8High activity binding peptidesCritical residuesInvasion inhibitionP. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.P. falciparum: Los péptidos de la proteína de superficie 8 de merezoito se unen específicamente a los eritrocitos humanos.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Vanegas, MagnoliaTovar, DianaLópez, RamsesPuentes, ALvaroGarcía, JavierOcampo, Marisol10336/26683oai:repository.urosario.edu.co:10336/266832021-06-03 00:49:57.495https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
dc.title.TranslatedTitle.spa.fl_str_mv P. falciparum: Los péptidos de la proteína de superficie 8 de merezoito se unen específicamente a los eritrocitos humanos.
title P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
spellingShingle P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
P. falciparum
MSP-8
High activity binding peptides
Critical residues
Invasion inhibition
title_short P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
title_full P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
title_fullStr P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
title_full_unstemmed P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
title_sort P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.
dc.subject.keyword.spa.fl_str_mv P. falciparum
MSP-8
High activity binding peptides
Critical residues
Invasion inhibition
topic P. falciparum
MSP-8
High activity binding peptides
Critical residues
Invasion inhibition
description This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein’s possible role in the invasion process.
publishDate 2003
dc.date.created.spa.fl_str_mv 2003-07
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:02Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:02Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/S0196-9781(03)00185-2
dc.identifier.issn.none.fl_str_mv ISSN: 0196-9781
EISSN: 1873-5169
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26683
url https://doi.org/10.1016/S0196-9781(03)00185-2
https://repository.urosario.edu.co/handle/10336/26683
identifier_str_mv ISSN: 0196-9781
EISSN: 1873-5169
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1023
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 1015
dc.relation.citationTitle.none.fl_str_mv Peptides
dc.relation.citationVolume.none.fl_str_mv Vol. 24
dc.relation.ispartof.spa.fl_str_mv Peptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.24, No.7 (July 2003); pp. 1015-1023
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0196978103001852?via%3Dihub
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Peptides
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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