Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.

On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered i...

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Tipo de recurso:
Fecha de publicación:
1989
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27170
Acceso en línea:
https://doi.org/10.1007/978-3-7091-9029-6_9
https://repository.urosario.edu.co/handle/10336/27170
Palabra clave:
Spasticity
Intrathecal
Baclofen
Infusion pump
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License
Restringido (Acceso a grupos específicos)
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network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 995dfde8-7ead-4c91-b695-376533439b8c-1bd976a83-96c3-4f4c-8fc4-492304e8ff32-12332c8fd-de58-4332-8972-4d28dc3b39fb-17f6f79c3-4358-4674-a088-b521584f1872-1cc9216a5-ce48-4fe2-a6c6-f9b36c97ba94-146b1a31a-e59a-4003-a374-fb75caf45d60-13277ca3a-b8ef-4c21-bbc1-e91282d14ac6-12020-08-19T14:41:13Z2020-08-19T14:41:13Z1989On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 ?g, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 ?g per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed.application/pdfhttps://doi.org/10.1007/978-3-7091-9029-6_9ISSN: 0065-1419EISSN: 2197-8395ISBN: 978-3-7091-9031-9EISBN: 978-3-7091-9029-6https://repository.urosario.edu.co/handle/10336/27170engSpringer Nature4539Acta Neurochirurgica;Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8Vol. 46Acta Neurochirurgica, Supplement, ISSN: 0065-1419; EISSN: 2197-8395, Vol.46 (1989);pp. 39-45Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8, ISBN: 978-3-7091-9031-9 ; EISBN: 978-3-7091-9029-6, Supl.46 (1989); pp. 39-45https://link.springer.com/chapter/10.1007%2F978-3-7091-9029-6_9Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecActa NeurochirurgicaActa Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSpasticityIntrathecalBaclofenInfusion pumpUse of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.Uso de baclofeno intratecal administrado por bombas de infusión programables en espasticidad resistente.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Broseta, J.Morales, F.Garcia, G.Sanchez Ledesma, M. J.Anaja, J.Gonzalez Darder, J.Barberá, J.10336/27170oai:repository.urosario.edu.co:10336/271702021-06-03 00:50:06.933https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
dc.title.TranslatedTitle.spa.fl_str_mv Uso de baclofeno intratecal administrado por bombas de infusión programables en espasticidad resistente.
title Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
spellingShingle Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
Spasticity
Intrathecal
Baclofen
Infusion pump
title_short Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
title_full Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
title_fullStr Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
title_full_unstemmed Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
title_sort Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
dc.subject.keyword.spa.fl_str_mv Spasticity
Intrathecal
Baclofen
Infusion pump
topic Spasticity
Intrathecal
Baclofen
Infusion pump
description On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 ?g, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 ?g per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed.
publishDate 1989
dc.date.created.spa.fl_str_mv 1989
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:41:13Z
dc.date.available.none.fl_str_mv 2020-08-19T14:41:13Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/978-3-7091-9029-6_9
dc.identifier.issn.none.fl_str_mv ISSN: 0065-1419
EISSN: 2197-8395
ISBN: 978-3-7091-9031-9
EISBN: 978-3-7091-9029-6
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27170
url https://doi.org/10.1007/978-3-7091-9029-6_9
https://repository.urosario.edu.co/handle/10336/27170
identifier_str_mv ISSN: 0065-1419
EISSN: 2197-8395
ISBN: 978-3-7091-9031-9
EISBN: 978-3-7091-9029-6
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 45
dc.relation.citationStartPage.none.fl_str_mv 39
dc.relation.citationTitle.none.fl_str_mv Acta Neurochirurgica;Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8
dc.relation.citationVolume.none.fl_str_mv Vol. 46
dc.relation.ispartof.spa.fl_str_mv Acta Neurochirurgica, Supplement, ISSN: 0065-1419; EISSN: 2197-8395, Vol.46 (1989);pp. 39-45
Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8, ISBN: 978-3-7091-9031-9 ; EISBN: 978-3-7091-9029-6, Supl.46 (1989); pp. 39-45
dc.relation.uri.spa.fl_str_mv https://link.springer.com/chapter/10.1007%2F978-3-7091-9029-6_9
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Springer Nature
dc.source.spa.fl_str_mv Acta Neurochirurgica
Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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