Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered i...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 1989
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27170
- Acceso en línea:
- https://doi.org/10.1007/978-3-7091-9029-6_9
https://repository.urosario.edu.co/handle/10336/27170
- Palabra clave:
- Spasticity
Intrathecal
Baclofen
Infusion pump
- Rights
- License
- Restringido (Acceso a grupos específicos)
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995dfde8-7ead-4c91-b695-376533439b8c-1bd976a83-96c3-4f4c-8fc4-492304e8ff32-12332c8fd-de58-4332-8972-4d28dc3b39fb-17f6f79c3-4358-4674-a088-b521584f1872-1cc9216a5-ce48-4fe2-a6c6-f9b36c97ba94-146b1a31a-e59a-4003-a374-fb75caf45d60-13277ca3a-b8ef-4c21-bbc1-e91282d14ac6-12020-08-19T14:41:13Z2020-08-19T14:41:13Z1989On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 ?g, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 ?g per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed.application/pdfhttps://doi.org/10.1007/978-3-7091-9029-6_9ISSN: 0065-1419EISSN: 2197-8395ISBN: 978-3-7091-9031-9EISBN: 978-3-7091-9029-6https://repository.urosario.edu.co/handle/10336/27170engSpringer Nature4539Acta Neurochirurgica;Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8Vol. 46Acta Neurochirurgica, Supplement, ISSN: 0065-1419; EISSN: 2197-8395, Vol.46 (1989);pp. 39-45Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8, ISBN: 978-3-7091-9031-9 ; EISBN: 978-3-7091-9029-6, Supl.46 (1989); pp. 39-45https://link.springer.com/chapter/10.1007%2F978-3-7091-9029-6_9Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecActa NeurochirurgicaActa Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSpasticityIntrathecalBaclofenInfusion pumpUse of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.Uso de baclofeno intratecal administrado por bombas de infusión programables en espasticidad resistente.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Broseta, J.Morales, F.Garcia, G.Sanchez Ledesma, M. J.Anaja, J.Gonzalez Darder, J.Barberá, J.10336/27170oai:repository.urosario.edu.co:10336/271702021-06-03 00:50:06.933https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
dc.title.TranslatedTitle.spa.fl_str_mv |
Uso de baclofeno intratecal administrado por bombas de infusión programables en espasticidad resistente. |
title |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
spellingShingle |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. Spasticity Intrathecal Baclofen Infusion pump |
title_short |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
title_full |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
title_fullStr |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
title_full_unstemmed |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
title_sort |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. |
dc.subject.keyword.spa.fl_str_mv |
Spasticity Intrathecal Baclofen Infusion pump |
topic |
Spasticity Intrathecal Baclofen Infusion pump |
description |
On the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 ?g, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 ?g per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed. |
publishDate |
1989 |
dc.date.created.spa.fl_str_mv |
1989 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:41:13Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:41:13Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/978-3-7091-9029-6_9 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0065-1419 EISSN: 2197-8395 ISBN: 978-3-7091-9031-9 EISBN: 978-3-7091-9029-6 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27170 |
url |
https://doi.org/10.1007/978-3-7091-9029-6_9 https://repository.urosario.edu.co/handle/10336/27170 |
identifier_str_mv |
ISSN: 0065-1419 EISSN: 2197-8395 ISBN: 978-3-7091-9031-9 EISBN: 978-3-7091-9029-6 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
45 |
dc.relation.citationStartPage.none.fl_str_mv |
39 |
dc.relation.citationTitle.none.fl_str_mv |
Acta Neurochirurgica;Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8 |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 46 |
dc.relation.ispartof.spa.fl_str_mv |
Acta Neurochirurgica, Supplement, ISSN: 0065-1419; EISSN: 2197-8395, Vol.46 (1989);pp. 39-45 Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8, ISBN: 978-3-7091-9031-9 ; EISBN: 978-3-7091-9029-6, Supl.46 (1989); pp. 39-45 |
dc.relation.uri.spa.fl_str_mv |
https://link.springer.com/chapter/10.1007%2F978-3-7091-9029-6_9 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer Nature |
dc.source.spa.fl_str_mv |
Acta Neurochirurgica Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8 |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167673769033728 |