Common mechanisms of autoimmune diseases (the autoimmune tautology)

The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms and genetic factors has been called autoimmune tautology, and indicates that they have a common origin. The autoimmune phenotypes vary depending on the target cell and the affected organ, gender, ancestry, trigger f...

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Autores:
Tipo de recurso:
Fecha de publicación:
2012
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23110
Acceso en línea:
https://doi.org/10.1016/j.autrev.2012.02.002
https://repository.urosario.edu.co/handle/10336/23110
Palabra clave:
Autoimmune disease
Autoimmunity
Clinical feature
Disease severity
Environmental factor
Familial disease
Genetic disorder
Heredity
Human
Immune response
Onset age
Pathophysiology
Phenotype
Review
Risk factor
T lymphocyte
Target cell
Age of onset
Autoimmune diseases
Autoimmunity
Environment
Family
Humans
Phenotype
Sex factors
Autoantibodies
Autoimmune diseases
Autoimmune tautology
Familial autoimmunity
Genetics
Polyautoimmunity
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Abierto (Texto Completo)
Description
Summary:The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms and genetic factors has been called autoimmune tautology, and indicates that they have a common origin. The autoimmune phenotypes vary depending on the target cell and the affected organ, gender, ancestry, trigger factors and age at onset. Ten shared characteristics supporting this logical theory are herein reviewed. © 2012 Elsevier B.V.