Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.

The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in...

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Autores:
Tipo de recurso:
Fecha de publicación:
2004
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27865
Acceso en línea:
https://doi.org/10.1016/j.vaccine.2003.08.046
https://repository.urosario.edu.co/handle/10336/27865
Palabra clave:
Peptide
Malaria
SERA
NMR
Rights
License
Restringido (Acceso a grupos específicos)
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oai_identifier_str oai:repository.urosario.edu.co:10336/27865
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling f6e85b0e-a9b5-4835-8e23-01bd8bdd87be-1dbe17748-4c0d-479b-ac09-27bf4a63b6e5-1fc4b5f0d-82d4-49e3-82f8-b1a1e513a6a5-151721018-1faaf745c-61cf-4170-a36f-07c6154b327c-19e3ba9df-fe89-48fe-9521-cc8f452d56f5-12020-08-19T14:44:19Z2020-08-19T14:44:19Z2004The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules.application/pdfhttps://doi.org/10.1016/j.vaccine.2003.08.046ISSN: 0264-410XEISSN: 1873-2518https://repository.urosario.edu.co/handle/10336/27865engElsevier1289No. 9-101281VaccineVol. 22Vaccine, ISSN: 0264-410X ;EISSN: 1873-2518, vol.22, No.9-10 (March 2004); pp. 1281-1289https://www.sciencedirect.com/science/article/pii/S0264410X03006819Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecVaccineinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPeptideMalariaSERANMRInduction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.La inducción y el desplazamiento de una hélice en el análogo del péptido SERA 6725 confiere protección contra la malaria por P. falciparum.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Alaba, Martha PatriciaSalazar, Luz MaryPurmova, JindraVanegas, MagnoliaRodriguez, RaulPatarroyo, Manuel Elkin10336/27865oai:repository.urosario.edu.co:10336/278652022-05-02 07:37:21.941011https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
dc.title.TranslatedTitle.spa.fl_str_mv La inducción y el desplazamiento de una hélice en el análogo del péptido SERA 6725 confiere protección contra la malaria por P. falciparum.
title Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
spellingShingle Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
Peptide
Malaria
SERA
NMR
title_short Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_full Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_fullStr Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_full_unstemmed Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_sort Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
dc.subject.keyword.spa.fl_str_mv Peptide
Malaria
SERA
NMR
topic Peptide
Malaria
SERA
NMR
description The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules.
publishDate 2004
dc.date.created.spa.fl_str_mv 2004
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:44:19Z
dc.date.available.none.fl_str_mv 2020-08-19T14:44:19Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.vaccine.2003.08.046
dc.identifier.issn.none.fl_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27865
url https://doi.org/10.1016/j.vaccine.2003.08.046
https://repository.urosario.edu.co/handle/10336/27865
identifier_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1289
dc.relation.citationIssue.none.fl_str_mv No. 9-10
dc.relation.citationStartPage.none.fl_str_mv 1281
dc.relation.citationTitle.none.fl_str_mv Vaccine
dc.relation.citationVolume.none.fl_str_mv Vol. 22
dc.relation.ispartof.spa.fl_str_mv Vaccine, ISSN: 0264-410X ;EISSN: 1873-2518, vol.22, No.9-10 (March 2004); pp. 1281-1289
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0264410X03006819
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Vaccine
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167444098383872

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