Genetics and vaccines in the era of personalized medicine

Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known facto...

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Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23806
Acceso en línea:
https://doi.org/10.2174/1389202916666141223220551
https://repository.urosario.edu.co/handle/10336/23806
Palabra clave:
CD45 antigen
Cell surface receptor
Cytokine
Hepatitis B vaccine
Influenza vaccine
Measles mumps rubella vaccine
Poliomyelitis vaccine
Rabies vaccine
Toll like receptor
Vaccine
Vaccinia vaccine
Allele
Antigen presentation
Article
Autoimmune disease
Autoimmunity
DNA modification
DNA polymorphism
Drug design
Gene function
Gene interaction
Genetic association
Genetics
Haplotype
Heredity
HLA system
Human
Immune response
Immunization
Immunogenicity
Personalized medicine
Smallpox
Streptococcus agalactiae
Streptococcus group A
Autoimmune ecology
Autoimmunity and systems biology
Genetics
HLA
Infection
Personalized medicine
Vaccine
Rights
License
Abierto (Texto Completo)
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spelling 51cf37f6-25b0-4152-ae95-bb2b21ce5d7e194747786002020-05-26T00:05:35Z2020-05-26T00:05:35Z2015Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach. ©2015 Bentham Science Publishers.application/pdfhttps://doi.org/10.2174/138920291666614122322055113892029https://repository.urosario.edu.co/handle/10336/23806engBentham Science Publishers B.V.59No. 147Current GenomicsVol. 16Current Genomics, ISSN:13892029, Vol.16, No.1 (2015); pp. 47-59https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926287802&doi=10.2174%2f1389202916666141223220551&partnerID=40&md5=8b7de78028c96f9638ecd7f41b61ef8eAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCD45 antigenCell surface receptorCytokineHepatitis B vaccineInfluenza vaccineMeasles mumps rubella vaccinePoliomyelitis vaccineRabies vaccineToll like receptorVaccineVaccinia vaccineAlleleAntigen presentationArticleAutoimmune diseaseAutoimmunityDNA modificationDNA polymorphismDrug designGene functionGene interactionGenetic associationGeneticsHaplotypeHeredityHLA systemHumanImmune responseImmunizationImmunogenicityPersonalized medicineSmallpoxStreptococcus agalactiaeStreptococcus group AAutoimmune ecologyAutoimmunity and systems biologyGeneticsHLAInfectionPersonalized medicineVaccineGenetics and vaccines in the era of personalized medicinearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Castiblanco, JohnAnaya, Juan-Manuel10336/23806oai:repository.urosario.edu.co:10336/238062022-05-02 07:37:13.592284https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Genetics and vaccines in the era of personalized medicine
title Genetics and vaccines in the era of personalized medicine
spellingShingle Genetics and vaccines in the era of personalized medicine
CD45 antigen
Cell surface receptor
Cytokine
Hepatitis B vaccine
Influenza vaccine
Measles mumps rubella vaccine
Poliomyelitis vaccine
Rabies vaccine
Toll like receptor
Vaccine
Vaccinia vaccine
Allele
Antigen presentation
Article
Autoimmune disease
Autoimmunity
DNA modification
DNA polymorphism
Drug design
Gene function
Gene interaction
Genetic association
Genetics
Haplotype
Heredity
HLA system
Human
Immune response
Immunization
Immunogenicity
Personalized medicine
Smallpox
Streptococcus agalactiae
Streptococcus group A
Autoimmune ecology
Autoimmunity and systems biology
Genetics
HLA
Infection
Personalized medicine
Vaccine
title_short Genetics and vaccines in the era of personalized medicine
title_full Genetics and vaccines in the era of personalized medicine
title_fullStr Genetics and vaccines in the era of personalized medicine
title_full_unstemmed Genetics and vaccines in the era of personalized medicine
title_sort Genetics and vaccines in the era of personalized medicine
dc.subject.keyword.spa.fl_str_mv CD45 antigen
Cell surface receptor
Cytokine
Hepatitis B vaccine
Influenza vaccine
Measles mumps rubella vaccine
Poliomyelitis vaccine
Rabies vaccine
Toll like receptor
Vaccine
Vaccinia vaccine
Allele
Antigen presentation
Article
Autoimmune disease
Autoimmunity
DNA modification
DNA polymorphism
Drug design
Gene function
Gene interaction
Genetic association
Genetics
Haplotype
Heredity
HLA system
Human
Immune response
Immunization
Immunogenicity
Personalized medicine
Smallpox
Streptococcus agalactiae
Streptococcus group A
Autoimmune ecology
Autoimmunity and systems biology
Genetics
HLA
Infection
Personalized medicine
Vaccine
topic CD45 antigen
Cell surface receptor
Cytokine
Hepatitis B vaccine
Influenza vaccine
Measles mumps rubella vaccine
Poliomyelitis vaccine
Rabies vaccine
Toll like receptor
Vaccine
Vaccinia vaccine
Allele
Antigen presentation
Article
Autoimmune disease
Autoimmunity
DNA modification
DNA polymorphism
Drug design
Gene function
Gene interaction
Genetic association
Genetics
Haplotype
Heredity
HLA system
Human
Immune response
Immunization
Immunogenicity
Personalized medicine
Smallpox
Streptococcus agalactiae
Streptococcus group A
Autoimmune ecology
Autoimmunity and systems biology
Genetics
HLA
Infection
Personalized medicine
Vaccine
description Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach. ©2015 Bentham Science Publishers.
publishDate 2015
dc.date.created.spa.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:05:35Z
dc.date.available.none.fl_str_mv 2020-05-26T00:05:35Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.2174/1389202916666141223220551
dc.identifier.issn.none.fl_str_mv 13892029
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23806
url https://doi.org/10.2174/1389202916666141223220551
https://repository.urosario.edu.co/handle/10336/23806
identifier_str_mv 13892029
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 59
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationStartPage.none.fl_str_mv 47
dc.relation.citationTitle.none.fl_str_mv Current Genomics
dc.relation.citationVolume.none.fl_str_mv Vol. 16
dc.relation.ispartof.spa.fl_str_mv Current Genomics, ISSN:13892029, Vol.16, No.1 (2015); pp. 47-59
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926287802&doi=10.2174%2f1389202916666141223220551&partnerID=40&md5=8b7de78028c96f9638ecd7f41b61ef8e
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Bentham Science Publishers B.V.
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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