Genetics and vaccines in the era of personalized medicine
Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known facto...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23806
- Acceso en línea:
- https://doi.org/10.2174/1389202916666141223220551
https://repository.urosario.edu.co/handle/10336/23806
- Palabra clave:
- CD45 antigen
Cell surface receptor
Cytokine
Hepatitis B vaccine
Influenza vaccine
Measles mumps rubella vaccine
Poliomyelitis vaccine
Rabies vaccine
Toll like receptor
Vaccine
Vaccinia vaccine
Allele
Antigen presentation
Article
Autoimmune disease
Autoimmunity
DNA modification
DNA polymorphism
Drug design
Gene function
Gene interaction
Genetic association
Genetics
Haplotype
Heredity
HLA system
Human
Immune response
Immunization
Immunogenicity
Personalized medicine
Smallpox
Streptococcus agalactiae
Streptococcus group A
Autoimmune ecology
Autoimmunity and systems biology
Genetics
HLA
Infection
Personalized medicine
Vaccine
- Rights
- License
- Abierto (Texto Completo)
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51cf37f6-25b0-4152-ae95-bb2b21ce5d7e194747786002020-05-26T00:05:35Z2020-05-26T00:05:35Z2015Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach. ©2015 Bentham Science Publishers.application/pdfhttps://doi.org/10.2174/138920291666614122322055113892029https://repository.urosario.edu.co/handle/10336/23806engBentham Science Publishers B.V.59No. 147Current GenomicsVol. 16Current Genomics, ISSN:13892029, Vol.16, No.1 (2015); pp. 47-59https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926287802&doi=10.2174%2f1389202916666141223220551&partnerID=40&md5=8b7de78028c96f9638ecd7f41b61ef8eAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCD45 antigenCell surface receptorCytokineHepatitis B vaccineInfluenza vaccineMeasles mumps rubella vaccinePoliomyelitis vaccineRabies vaccineToll like receptorVaccineVaccinia vaccineAlleleAntigen presentationArticleAutoimmune diseaseAutoimmunityDNA modificationDNA polymorphismDrug designGene functionGene interactionGenetic associationGeneticsHaplotypeHeredityHLA systemHumanImmune responseImmunizationImmunogenicityPersonalized medicineSmallpoxStreptococcus agalactiaeStreptococcus group AAutoimmune ecologyAutoimmunity and systems biologyGeneticsHLAInfectionPersonalized medicineVaccineGenetics and vaccines in the era of personalized medicinearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Castiblanco, JohnAnaya, Juan-Manuel10336/23806oai:repository.urosario.edu.co:10336/238062022-05-02 07:37:13.592284https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Genetics and vaccines in the era of personalized medicine |
title |
Genetics and vaccines in the era of personalized medicine |
spellingShingle |
Genetics and vaccines in the era of personalized medicine CD45 antigen Cell surface receptor Cytokine Hepatitis B vaccine Influenza vaccine Measles mumps rubella vaccine Poliomyelitis vaccine Rabies vaccine Toll like receptor Vaccine Vaccinia vaccine Allele Antigen presentation Article Autoimmune disease Autoimmunity DNA modification DNA polymorphism Drug design Gene function Gene interaction Genetic association Genetics Haplotype Heredity HLA system Human Immune response Immunization Immunogenicity Personalized medicine Smallpox Streptococcus agalactiae Streptococcus group A Autoimmune ecology Autoimmunity and systems biology Genetics HLA Infection Personalized medicine Vaccine |
title_short |
Genetics and vaccines in the era of personalized medicine |
title_full |
Genetics and vaccines in the era of personalized medicine |
title_fullStr |
Genetics and vaccines in the era of personalized medicine |
title_full_unstemmed |
Genetics and vaccines in the era of personalized medicine |
title_sort |
Genetics and vaccines in the era of personalized medicine |
dc.subject.keyword.spa.fl_str_mv |
CD45 antigen Cell surface receptor Cytokine Hepatitis B vaccine Influenza vaccine Measles mumps rubella vaccine Poliomyelitis vaccine Rabies vaccine Toll like receptor Vaccine Vaccinia vaccine Allele Antigen presentation Article Autoimmune disease Autoimmunity DNA modification DNA polymorphism Drug design Gene function Gene interaction Genetic association Genetics Haplotype Heredity HLA system Human Immune response Immunization Immunogenicity Personalized medicine Smallpox Streptococcus agalactiae Streptococcus group A Autoimmune ecology Autoimmunity and systems biology Genetics HLA Infection Personalized medicine Vaccine |
topic |
CD45 antigen Cell surface receptor Cytokine Hepatitis B vaccine Influenza vaccine Measles mumps rubella vaccine Poliomyelitis vaccine Rabies vaccine Toll like receptor Vaccine Vaccinia vaccine Allele Antigen presentation Article Autoimmune disease Autoimmunity DNA modification DNA polymorphism Drug design Gene function Gene interaction Genetic association Genetics Haplotype Heredity HLA system Human Immune response Immunization Immunogenicity Personalized medicine Smallpox Streptococcus agalactiae Streptococcus group A Autoimmune ecology Autoimmunity and systems biology Genetics HLA Infection Personalized medicine Vaccine |
description |
Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach. ©2015 Bentham Science Publishers. |
publishDate |
2015 |
dc.date.created.spa.fl_str_mv |
2015 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:05:35Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:05:35Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.2174/1389202916666141223220551 |
dc.identifier.issn.none.fl_str_mv |
13892029 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23806 |
url |
https://doi.org/10.2174/1389202916666141223220551 https://repository.urosario.edu.co/handle/10336/23806 |
identifier_str_mv |
13892029 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
59 |
dc.relation.citationIssue.none.fl_str_mv |
No. 1 |
dc.relation.citationStartPage.none.fl_str_mv |
47 |
dc.relation.citationTitle.none.fl_str_mv |
Current Genomics |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 16 |
dc.relation.ispartof.spa.fl_str_mv |
Current Genomics, ISSN:13892029, Vol.16, No.1 (2015); pp. 47-59 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926287802&doi=10.2174%2f1389202916666141223220551&partnerID=40&md5=8b7de78028c96f9638ecd7f41b61ef8e |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Bentham Science Publishers B.V. |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167691901009920 |